Embodiments of the present disclosure encompass systems and methods for in-situ/in vivo, bottom-up tissue generation for wound repair, repair of tissue defects, and the like. Embodiments of the systems of the present disclosure include modular scaffolds seeded with cells (modular tissue forming units (MTFUs)) for packing a tissue defect, such that these MTFUs are able to fill the wound bed with cells of one or more needed tissue types supported by the modular scaffolding particles.

A cold atmospheric plasma (CAP)-mediated ICB therapy/delivery device are disclosed herein that employs a patch having microneedles that are used to deliver the CAP transdermally along with an immune checkpoint inhibitor for enhancing transdermal treatment efficacy. The hollow-structured microneedle patch can facilitate the transportation of CAP through the skin, causing tumor cell death. The release of cancer antigens then promotes the maturation of dendritic cells in the tumor-draining lymph nodes, subsequently initiating the T cell-mediated immune response. Anti-PDL1 antibody (aPDL1), an immune checkpoint inhibitor (or other immune checkpoint inhibitors), released from the microneedle patch (in some embodiments) further augments the anti-tumor immunity. The transdermal combinational CAP and ICB therapy inhibits tumor growth for both primary tumors as well as distant tumors, with prolonged survival in the tumor-bearing mice. Such results should translate to other species.

An apparatus for treating skin has a console with a user input device and a handpiece assembly. The handpiece assembly is configured to treat skin. A fluid line provides fluid communication between the console and the handpiece assembly. A manifold system is coupled to the console and controlled by the user input device. The manifold system is configured to hold releasably a plurality of fluid sources and deliver fluid from at least one of the plurality of fluid sources to the handpiece assembly.

Methods and kits for treating or preventing an eye condition or for cleaning an eye area tissue are provided. A method of the invention includes administering an isoprenoidal essential oil to eye area tissue, chafing eye area tissue with an abrasive, and removing the abrasive. A kit according to the invention includes an isoprenoidal essential oil, an abrasive for chafing eye area tissue, and in instruction for use for treating an eye condition or cleansing an eye area tissue. The invention also includes a composition of matter comprising an isoprenoidal essential oil and a plurality of abrasive particles in ophthamologically acceptable base.

An apparatus and method for depositing a particulate containing composition onto mammalian skin such that when the particles contact the mammalian skin they have a momentum defined by ρvr, which is within the range of about 0.1 kg/ms≦ρvr≦about 12.0 kg/ms. The particles can be in the range of from about 10 nanometers to about 10 micrometers, in size. And the particles may be selected from the group consisting of titanium dioxide, zinc oxide, iron oxide, polyethylene, polypropylene, polyethylene terephthalate, polycarbonate, polyvinyl chloride, glass, silica and mixtures thereof. The particles are imbedded below the first layer of dead skin cells in the stratum corneum but they do not pass all the way through the stratum corneum into the living cells of the epidermis or dermis layers of the skin.

The present application includes a method for introducing a hormone directly into an affected area within a tumor. The method includes penetrating the affected area of the tumor with a biopsy needle in order to obtain a biopsy specimen. The specimen is withdrawn along with the biopsy needle. A hormone implant is inserted into the void space left behind as the specimen was removed. The method may also include directly inserting the implant and a treating substance into the tumor without the removal of the biopsy specimen. The implant may have various shapes in order to maximize surface contact. The implant is also configured to have a time release function to regulate dosage delivery.

The present disclosure relates generally to devices, systems, and methods for diagnosis and treatment via laser-treated skin and, more particularly, to devices, systems, and methods for inducing leakage or rupture of one or more blood vessels comprising the dermis for various diagnostic and therapeutic applications. Other aspects of the present disclosure can include methods for detecting one or more target analytes in a dermis of a subject, methods for facilitating skin-to-blood delivery of agent in a subject, and methods for collecting a fluid sample from the dermis of a subject.

The invention is broadly directed to a skin care apparatus comprising: a camera; a light device for emitting at least one of a blue, a green, a yellow and a red light; a vibration pad; a heating element; a heat sensor; a skin moisture sensor; an iontophoresis module; and a control processor configured to: operate the camera and the skin moisture sensor to perform a skin quality assessment of a user's skin, and operate any one or more of: the light device, the vibration pad, the heating element, the heat sensor, and the iontophoresis module to provide a bespoke skin treatment for the user's skin based on the skin quality assessment.

This application relates to a wearable multi-shot injection patch. In one aspect, the patch includes a base that has a bottom surface and a top surface and is configured so that the bottom surface is disposed against a patient's skin. The patch may also include a first container that is supported by the base and accommodates a first drug, and a second container that is supported by the base and accommodates a second drug. The patch may further include a first pyrotechnic charge disposed between the top surface and the first container inside the base, and a second pyrotechnic charge disposed between the top surface and the second container inside the base. The patch may further include one or more electronic components configured to detonate the first pyrotechnic charge and the second pyrotechnic charge.

Biomarkers are collected and used to determine biological propensities of a patient, to determine the efficacy of medical devices, to select and administer therapeutic agents, to select medical devices, to make adjustments to medical devices, and/or to adjust surgical techniques. An apparatus includes a port to draw a biological fluid (e.g., a mist) from a surgical site. The apparatus includes a sensor having a cantilevered beam. The beam includes substances selected to attract certain biomarkers as the fluid is communicated across the beam. The same apparatus or another apparatus is used to administer a therapeutic agent based at least in part on collected biomarker data. The therapeutic agent delivery apparatus may include a device that is also used to create a wound at a surgical site. For instance, a harmonic surgical instrument may be used to both collect biomarkers and administer a therapeutic agent (e.g., gene therapy using sonoporation).