Disclosed herein are advantageous drug delivery assemblies, and related methods of fabrication and use thereof. The present disclosure provides improved drug delivery assemblies for extended drug delivery (e.g., via passive diffusion) and/or tunability, and improved systems/methods for utilizing and fabricating the drug delivery assemblies. More particularly, the present disclosure provides single or dual compartment, and dual porous membrane based (e.g., porous zinc membrane based) drug delivery assemblies for extended drug delivery (e.g., via passive diffusion) and/or tunability. The present disclosure also provides for a method for utilizing a drug delivery assembly. The assemblies can be utilized for the extended drug delivery of pharmaceuticals or the like, such as biologics, for the sustained release of medication for greater than six months to overcome difficulties with daily dosing regimes.

Disclosed is a drug injection device that is fixedly implanted a patient's skull and scalp to inject a drug. The disclosed drug injection device includes a main body that is fixedly implanted in contact with a skull and has an internal hole; a main body fixing part that has an internal hole to be adjacent to the main body and is fixedly coupled to the main body; a movable part that is positioned between the main body and the main body fixing part, has a drug injection hole at a central part thereof, and is able to change its direction to a target point; a sealing part that is configured to seal the drug injection hole of the movable part, into which an injection needle for injecting a drug is inserted; a movable lid part that is positioned above the sealing part to close and fix the movable part, prevents the sealing part from being separated and escaping outside, and identifies an implantation position of the drug injection device to guide a point for repeated administration; and at least two fastening members that fasten an upper part of the main body and an upper part of the main body fixing part to the skull, in which the main body includes a support part that is positioned above the skull for support, an outer diameter of the support part is smaller than an outer diameter of the main body fixing part and is greater than an outer diameter of the movable part, and the main body and the main body fixing part are adjacently coupled to each other to accommodate and fix the movable part in the internal hole of the main body.

Disclosed are introducer components, assemblies, and methods. For example, an introducer assembly can include a fluidly connected syringe and needle. The needle can include a needle shaft and a needle hub over a proximal portion of the needle shaft. The needle hub can include a port and a valve disposed in the port. The port can be in a side of the needle hub proximal of a proximal end of the needle shaft. The valve can be configured to form a fluid-tight seal around an elongate medical device such as an access guidewire when passed through the port and into a needle-hub lumen of the needle hub. Such an access guidewire can be disposed in the introducer assembly just proximal of a needle tip of the needle. In this way, the access guidewire can be immediately advanced into a blood-vessel lumen upon establishing a needle tract thereto with the needle.

A valve device suitable for detachably fixing to an access port and includes a fixation clip which has at least a first and second fixation member each of which have one or more rims each having a surface which veers in a direction towards the valve device. There is further provided a removing tool for removing the valve device from an access port. There is further provided a mounting tool for mounting a valve device in an access port. An assembly having a mounting tool and a valve device is also provided.

A chest drainage system securing apparatus for securing and maintaining chest drainage systems in position following placement into a human or animal patient and preventing movement or unplanned removal thereof in response to the application of significant forces in any direction thereto, be they longitudinal, torsional/rotational or bending. The securement system includes retention devices secured to a chest tube which interact with an adhesive pad releasably attached to a patient to ensure proper positioning of the chest tube. The adhesive pad includes one or more Heimlich-type valves for sealing sucking chest wounds and for sealing an incision formed in a patients skin and chest for the placement and insertion of a chest tube.

An access port can be connected to a catheter and includes a port body including a liquid storage portion and a diaphragm body covering the liquid storage portion. The port body includes a connection passage connected to the liquid storage portion and allows the liquid storage portion to communicate with the inside of the catheter. In the cross-section along the axial direction of the connection passage at the connection position where the connection passage is connected to the liquid storage portion, the length in the direction perpendicular to the axial direction between the surface of the diaphragm body on the side opposite to the liquid storage portion and the inner surface of the liquid storage portion gradually decreases as it proceeds away from the connection position in the inclined region exceeding half of the liquid storage portion along the axial direction.

A hemostasis seal member for a medical device, the seal member comprises a cylindrical main body portion having a proximal face, a distal face, and a peripheral surface face extending between the proximal and distal faces, the main body portion having a first diameter, and a radial sealing feature extending radially inward or outward from the peripheral surface and configured to sealingly engage an inner cylindrical surface of a hemostasis valve housing. The radial sealing feature comprises a radial projection extending radially outward from the peripheral surface, or a concave recess extending radially inward from the peripheral surface.

The disclosure relates to a subcutaneously implanted port device for establishing access to the vascular system of a patient requiring multiple blood treatments over an extended period of time. The systems, devices and methods disclosed herein may reduce miscannulation, promote intra-session hemostasis, and decrease the incidence of bacteremia and sepsis among other improvements and advantages. The devices include a port with a tapered seat for receiving an access tube, the first tapered seat having a proximal portion, a distal portion, and a conical section extending between the proximal portion and the distal portion; and an interface surface configured to engage a blood vessel or a vascular access catheter. The proximal portion of the tapered seat is configured to receive the access tube therethrough, and the tapered seat creates a mismatch fit with a diameter of the access tube when in use for an increase in flow during treatment.

A system for facilitating instrument delivery through a peripheral intravenous catheter may include a catheter adapter having a proximal end, a distal end, and a lumen extending there through. The catheter adapter may include a side port. The system may include an extension tube extending from the side port. The system may include a blood control valve disposed in the lumen of the catheter adapter. The system may include a peripheral intravenous catheter extending distally from the catheter adapter.

A skin-safe effluent containment system that may be used to contain fluid leakage from openings in the body of a patient and will adhere to skin in any condition: healthy or injured, wet or dry, smooth, scarred, or uneven. Fluid leakage can occur from natural orifices such as the anus and vagina, spontaneously formed enteric fistulas, rectovaginal fistulas, and surgical openings such as ileostomy and colostomy stomas. The system includes a vacuum-adherent pouch device, comprised of a pouch connected to a porous foam ring which has an air-permeable contact layer on its bottom surface and an air seal on its top surface. The inner and outer perimeters of the foam ring are enclosed and sealed with skin-adhesive materials. When placed on the patient, negative pressure (vacuum) is applied to the foam ring so that the foam collapses and compresses the vacuum-adherent pouch device down against the patient's skin. Negative pressure in combination with the adhesive materials on the perimeters of the foam ring forms a fluid barrier around the opening in the body of the patient so that leakage can be directed into the pouch and drawn away to a separate effluent container.