Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

The present technology relates to systems and/or methods for enabling a respiratory device to be configured when a clinician or healthcare professional is remote from the respiratory device. One form provides a method of configuring a respiratory device, the respiratory device comprising a processor configured to control operation of the respiratory device in accordance with a plurality of operating parameters. The method comprises determining a combination of settings for the device from an identifier sent to the device, the identifier corresponding to the combination of settings, and configuring the respiratory device accordingly. Another form provides a method of verifying the configuration of the respiratory device by outputting an identifier corresponding to the combination of settings for the device, and determining the settings from the identifier.

The present technology relates to systems and/or methods for enabling a respiratory device to be configured when a clinician or healthcare professional is remote from the respiratory device. One form provides a method of configuring a respiratory device, the respiratory device comprising a processor configured to control operation of the respiratory device in accordance with a plurality of operating parameters. The method comprises determining a combination of settings for the device from an identifier sent to the device, the identifier corresponding to the combination of settings, and configuring the respiratory device accordingly. Another form provides a method of verifying the configuration of the respiratory device by outputting an identifier corresponding to the combination of settings for the device, and determining the settings from the identifier.

The present invention provides new devices, systems, and methods for delivering enriched oxygen to recipients (e.g., chronically ill patients, such as COPD patients). One aspect is a more efficient portable oxygen concentrator that is configured to deliver an enriched oxygen airflow having a significantly lower overall oxygen concentration and greater overall volume administered as compared to currently marketed or known portable oxygen concentrators. Administering the lower oxygen concentration at higher volumes allows for the present portable oxygen concentrators to deliver an equivalent number of moles of oxygen as administered by traditional portable concentrators while increasing the efficiency of the system and the ability of the system to maintain the therapeutic level of oxygen concentration for a longer period.

Provided is an exacerbation prediction device equipped with a respiration sensing means of continuously sensing respiration data of a patient, a calculation means of calculating stable respiration data that are respiration data during a condition in which a respiratory rate is lowered and stable for a certain period of time from the sensed continuous respiration data of the patient, and a prediction means of predicting occurrence of an acute exacerbation in the patient in accordance with the stable respiration data calculated during a certain period of time.

Provided is an exacerbation prediction device equipped with a respiration sensing means of continuously sensing respiration data of a patient, a calculation means of calculating stable respiration data that are respiration data during a condition in which a respiratory rate is lowered and stable for a certain period of time from the sensed continuous respiration data of the patient, and a prediction means of predicting occurrence of an acute exacerbation in the patient in accordance with the stable respiration data calculated during a certain period of time.

Provided is a system for adsorbing a gaseous component comprising nitrogen from a pressurized flow of air containing the gaseous component. The system comprises a first adsorption bed, and a second adsorption bed. Each of the adsorption beds are suitable for selectively adsorbing the gaseous component from the flow of air to produce a product gas having a higher oxygen concentration than that of the air. The system includes an adjustable feed gas supply which alternately supplies the first adsorption bed and the second adsorption bed with the air. The first adsorption bed is supplied with air during a first half cycle of operation of the system, and the second adsorption bed is then supplied with air during a second half cycle of operation of the system. The feed gas supply enables adjustment of at least one parameter relating to the amount or respective amounts of air being supplied to the first adsorption bed in the first half cycle and/or to the second adsorption bed in the second half cycle. A connection and valve assembly is provided between the first and second adsorption beds. The connection and valve assembly diverts a portion of the product gas, produced from the respective absorption bed being supplied with the flow of air during the respective half cycle, to the other adsorption bed. This causes previously adsorbed gaseous component to be released from latter. The released gaseous component then escapes from the system, e.g. to the atmosphere, via a vent. A sensor system determines a measure of the flow rate of waste gas, including the released gaseous component, escaping from the system via the vent. The at least one parameter can be adjusted based on the measure in order to tune the performance of the system. Further provided is a method for operating the system.

Provided is a system for adsorbing a gaseous component comprising nitrogen from a pressurized flow of air containing the gaseous component. The system comprises a first adsorption bed, and a second adsorption bed. Each of the adsorption beds are suitable for selectively adsorbing the gaseous component from the flow of air to produce a product gas having a higher oxygen concentration than that of the air. The system includes an adjustable feed gas supply which alternately supplies the first adsorption bed and the second adsorption bed with the air. The first adsorption bed is supplied with air during a first half cycle of operation of the system, and the second adsorption bed is then supplied with air during a second half cycle of operation of the system. The feed gas supply enables adjustment of at least one parameter relating to the amount or respective amounts of air being supplied to the first adsorption bed in the first half cycle and/or to the second adsorption bed in the second half cycle. A connection and valve assembly is provided between the first and second adsorption beds. The connection and valve assembly diverts a portion of the product gas, produced from the respective absorption bed being supplied with the flow of air during the respective half cycle, to the other adsorption bed. This causes previously adsorbed gaseous component to be released from latter. The released gaseous component then escapes from the system, e.g. to the atmosphere, via a vent. A sensor system determines a measure of the flow rate of waste gas, including the released gaseous component, escaping from the system via the vent. The at least one parameter can be adjusted based on the measure in order to tune the performance of the system. Further provided is a method for operating the system.

An oxygen concentrator may have a compressor to feed a feed gas for sieve bed(s) via a first manifold, an accumulator to receive enriched air from the bed(s) via a second manifold. It may include an outer housing for the manifolds, the compressor, and the accumulator. The housing may include an access portal to a compartment therein, for removably receiving the bed(s) as a canister assembly. The first manifold may be adjacent to the compartment and have inlet coupling(s) for removably coupling respectively with inlet(s) of the canister assembly. The inlet coupling(s) may each have a first central axis. The second manifold may be adjacent to the compartment and have outlet coupling(s) for removably coupling respectively with outlet(s) of the canister assembly. The outlet coupling(s) may each having a second central axis. The first and second central axes may form any one of an obtuse, acute, or right angle.