The invention relates to a system for treating a biological fluid such as blood or a blood component by selective removal of a target substance, comprising a treatment bag (2) provided with at least one inlet orifice (3) and at least one outlet orifice (4), said treatment bag containing a set of particles (5) having an affinity for the target substance, said set comprising small particles having a size of less than 15 μm, said system further comprising a barrier means (6) composed of at least one porous membrane made of a hydrophilic material, the pores of said membrane being calibrated to a size suitable for preventing the passage of said small particles, namely less than 3 μm.

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.

A process for preparing blood components from blood, by means of a biomedical device (16), comprising the steps of: subjecting an isolated blood sample (1) to a first centrifugation at a speed of 250 rpm for a time of 10 minutes, and to a second centrifugation at a speed of 2000 rpm for a time of 15 minutes.

A processing device includes a pump system, a valve system, a centrifuge, and a controller. A fluid flow circuit is mounted to the device to execute a procedure in which whole blood is processed into a red blood cell product, a plasma product, and a platelet concentrate product. The blood is first separated into red blood cells, buffy coat, and plasma using the centrifuge, with the red blood cells and plasma being removed from the centrifuge, while the buffy coat remains in the centrifuge. The fluid remaining in the centrifuge is circulated through the centrifuge to form a homogenous mixture. Once the mixture is formed, it is separated in the centrifuge into platelet concentrate and red blood cells. A platelet product is then collected by using whole blood or previously collected red blood cells to push the platelet concentrate from the centrifuge to a collection container.

An apparatus for detecting the approximate number of leukocytes in a dialysate after the use thereof in peritoneal dialysis and for the analysis thereof, where the apparatus includes a housing having a through-opening for inserting a light-permeable tube and having an integrated tube clamping device, at least one laser light source directed onto the tube, a light detector device having a signal evaluation device, a display, and a power supply for the light source, the light detector device having the light signal evaluation device, and the display. The laser light source and the light detector device are arranged at an angle to one another such that the light detector device only detects the scattered radiation reflected from scattering surfaces of solid particles and in that an LED light source is also arranged, which directs the light thereof onto the light detector device which measures the transmitted light intensity and, after detecting turbidity of the dialysate, increases the value of the detected scattered radiation accordingly.

The invention relates to a filtration unit for the leucocytapheresis of the blood or of a blood product. The filtration unit has an external pouch with at least one inlet orifice and with at least one outlet orifice. the external pouch contains a porous element interposed between the orifices. he porous element has at least one leucocytapheresis medium that works by adsorbing and/or by filtering out the leucocytes, and at least one nonwoven layer provided with bumps, each of the bumps having a perforation passing through it in the heightwise direction.

A blood donation system is provided that includes a plurality of collection containers (18, 20, 22, 24) interconnected by tubing (16, 28, 32, 34, 36, 38) and a leukocyte reduction filter (30). The system has a machine-readable identification code (48) associated therewith that is printed at repeated intervals on one of the tubings (16, 28, 32, 34, 36, 38), so as to define a plurality of discrete segments (44), each sized to contain a sample volume of blood or a blood product. After collection, heat seals (42) are formed on the tubing (16, 28, 32, 34, 36, 38) to capture in each segment (44) a volume of blood/blood product, such that a plurality of sample tubes are provided, each bearing the machine-readable identification code (48) and containing a volume of blood/blood product suitable for sample testing.

A blood treatment filter comprising a filter element, an inlet-side flexible container and an outlet-side flexible container, an inlet port, and a tubular outlet port, further comprises: an outlet-side frame sheet disposed between the filter element and the outlet-side flexible container; a first seal portion provided by sealing at least the filter element and the outlet-side frame sheet in a belt-shaped manner; and an annular second seal portion provided to surround the first seal portion, wherein on an outlet side of the filter element, a valley portion is formed at the first seal portion, the outlet port includes a protruding portion that protrudes to an inside of the container, and the protruding portion is provided with an opening at least a part of which overlaps with the first seal portion and which can communicate with a gap region formed by the valley portion.

An extracorporeal photopheresis system includes a separator with a disposable fluid circuit including a treatment container, an irradiation device configured to treat the contents of the treatment container, and a controller configured to control the system to perform a procedure including drawing anticoagulated whole blood into the fluid circuit from a blood source and returning to the blood source a treated target cell component, a portion of a red blood cell component remaining in the fluid circuit, and/or a portion of a plasma component remaining in the fluid circuit. The controller is further configured to estimate an end-of-procedure fluid balance estimated based on manual or automatic inputs including a patient body weight associated with the blood source and a total blood volume of the blood source, indicate the fluid balance to an operator, and receive one or more changes that affect the fluid balance after indicating the fluid balance.

Systems and method for verifying the timely placement of a container of biolocal cells or fluid within a treatment chamber of a biological fluid treating device are disclosed. The systems and methods utilize a sensor that detects the presence of a container at an appropriate and pre-determined time and, optionally, detects the weight of the container and cells.