A medical device comprising an implantable subcutaneous access port having a septum penetrable by a needle; the septum having a cavity located between an outer wall and an inner wall, the cavity containing a flowable media comprising a plurality of displaceable particles arranged to move in response to the needle being inserted through the outer wall and into the cavity and reposition around the needle.

Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle. The generated aerosol particles are extremely light-weight (few micrograms) and have very small wall thickness (couple of microns), which enables precise delivery of materials and rapid evaporation of solvent in their liquid walls. The process production rate is easily scalable. In terms of possible applications, liquid used for aerosol generation can be enriched with suspended or dissolved materials, for instance by a medical drug for direct delivery into a patient's airways, or by organic/inorganic solvent which solidifies during drying enabling formation of soft or rigid spherical shells out of particles with liquid shells. The blowing gas can have suspended micron/nano particles in it and these particles will be encapsulated by liquid walls of formed micro-shells, which can potentially solidify during their motion, and thus produced aerosols can be used as transport agents for material delivery. Formation of fine monodisperse liquid or solid foams is possible by collecting liquid micro-shells from the generated aerosol on a surface or in a vessel, while the liquid walls of particles of adhere to each other and then can solidify due to solvent evaporation, freezing or polymerization.

A medical device comprising an implantable subcutaneous access port having a septum penetrable by a needle; the septum having a cavity located between an outer wall and an inner wall, the cavity containing a flowable media comprising a plurality of displaceable particles arranged to move in response to the needle being inserted through the outer wall and into the cavity and reposition around the needle.

Methods of manufacturing tissue interfacing components, such as solid needles comprising one or more therapeutic agents, are disclosed. In some embodiments, a method for manufacturing a tissue interfacing component comprises compressing a granular therapeutic agent within a mold cavity of a mold to form a solid tissue interfacing component. The mold cavity may define an elongated shape extending along a longitudinal axis from an opening of the mold cavity to a distal end of the mold cavity, and the granular therapeutic agent may be compressed by moving a mold punch along the longitudinal axis towards the distal end. After compressing the granular therapeutic agent to form the solid tissue interfacing component, the tissue interfacing component may be removed from the mold and subsequently inserted into tissue to deliver the therapeutic agent to a subject.

The present invention generally relates to a process suitable for extracorporeal lung support. The process comprises contacting blood with a dialysis liquid separated by a semipermeable membrane. Oxygen is introduced into blood and/or into the dialysis liquid prior to contacting blood and dialysis liquid being separated by the semipermeable membrane. The process is versatile and allows for blood oxygenation as well as removal of at least one undesired substance occurring in the blood, selected from carbon dioxide, bicarbonate and hydrogen cations, from blood. Thereby, the present invention takes advantage of the Haldane effect in the extracorporeal contacting step. The undesired substance can be efficiently transported across a semipermeable membrane to the dialysis liquid. In contrast to extracorporeal carbon dioxide removal methods of the prior art (ECCCbR), the present invention employs a versatile dialysis liquid that allows to adjust the pH and buffering capacity of the dialysis liquid, to add fluids to the dialysis liquid and/or to the blood and to remove substances from the blood in the extracorporeal circuit, depending on the conditions and needs. The present invention also provides regeneration and recycling of the dialysis liquid, and thus for its repeated use. The present invention is suitable for treating human or animal subjects suffering from lung failure or lung disorders.

An ultrasonic medicine application device that strongly promotes medicine absorption, having a housing, a control panel and a circuit board inside the housing, a medicine supply mechanism and an ultrasonic massage mechanism on a bottom surface of the housing. The ultrasonic massage mechanism has a base panel having massage projections, and also an electrical ultrasonic vibration element, which drives the projections make high frequency ultrasonic vibration. The medicine supply mechanism is positioned between the ultrasonic massage mechanism and the circuit board, and is configured to supply medicine towards the ultrasonic massage mechanism.

Disclosed herein are aspects of portable vaporizers to deliver aliquots of heated air to material in a furnace. The furnace is multipurposed reducing heat loss, air leakage and delays in availability of air aliquots at the proper temperature for use. By dividing the furnace with an air permeable divider and placing material in the chamber a controller selectively providing electrical power to a heating element configured to heat air furnace. Upon application of suction to the fluid passage heated air passes through a divider which shapes the head of the heated plume before the aliquot of air reaches the material. A controller in signal communications with at least one temperature sensor controls the power flow to a heater to control the temperature produced by heating element(s).

A method of removing embolic material from a vessel with mechanical and aspiration assistance. The method comprises the steps of providing an aspiration catheter having a central lumen and a distal end, advancing the distal end of the aspiration catheter to obstructive material in a vessel, applying vacuum to the central lumen to draw clot into the central lumen, introducing a thrombus engagement tool into the central lumen, and manually manipulating the tip to engage clot between the tip and an inside wall of the central lumen.

Intravesical drug delivery devices that include a device body, a number of solid drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The drug tablets is positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen.

The invention relates to an inhaler, particularly an electronic cigarette product, comprising at least one evaporator device having at least one electrical evaporator for evaporating liquid supplied to the evaporator and an electronic control device for controlling and/or regulating the evaporator. A plurality of liquids are associated or can be associated with the evaporator device in such a way that the composition and/or the vapour production rate of the vapour/aerosol produced by the at least one evaporator can be adjusted and/or modified in a targeted manner, as the control device is designed for individual control of the at least one or each individual evaporator and/or for group control of the evaporators.