An implantable containment apparatus for receiving and retaining a biological moiety or a therapeutic device within a tissue bed is disclosed. The device includes a shaping element to maintain the device in a generally toroidal configuration and to return the apparatus to that configuration after deformation. The apparatus can be placed in a host tissue with minimal trauma to the patient. Methods for implanting and using the apparatus are also disclosed.

The invention relates to a blood treatment device for carrying out an extracorporeal blood treatment in which blood is guided in a blood guidance device having a main blood line and at least one secondary line, the latter being fluidically connected to the main blood line and the main blood line having a dialyzer and, downstream from the dialyzer, a blood treatment element, wherein the blood treatment device has a control device; and a pump configuration, which is equipped for generating blood flows in the main blood line and also in the at least one secondary line, wherein the control device is designed to operate the pump configuration in such a way that a first blood flow rate in the dialyzer is decoupled from a second blood flow rate in the blood treatment element. Furthermore, the invention relates to a blood guidance device for cooperation with the blood treatment device as well as for a blood treatment system.

One aspect of the invention relates to an intubation aid (10). The intubation aid (10) comprises an elongated main part (12), and the intubation aid (10) is provided with an operating device (26). The main part (12) is designed to be curved in a first region (18) of the main part (12), and the main part (12) is additionally designed to be curved in a second region (20) of the main part (12), said second region being separated from the first region (18) and being arranged adjacently to the free end (16) of the main part (12). The main part (12) additionally comprises a positioning device (24) which is designed to limit a translational displacement of a tube (46) placed on the intubation aid (10) in at least one direction. A second aspect of the invention relates to an intubation aid which can be placed on an endoscope.

Provided herein are compositions, methods, uses, and articles of manufacture for iodine treatment on mucosal membranes, and treatment of respiratory pathogens in this way—e.g., by inhalation and combined with the evaporation of steam. In certain embodiments, iodine treatment encompasses administration of compounds that release molecular iodine and/or physiologically active iodine-containing compounds.

A ventilator that moves breathable air into and out of the lungs of a patient. The ventilator includes an inspiratory circuit with an inlet, a bellows, and an outlet port for moving air into the lungs of the patient. An expiratory circuit includes an inlet port and a discharge port for moving the air out of the lungs. The inspiratory circuit is adjustable to control a number of breathes per time period and a volume of the breaths.

A peristaltic pump-based apparatus for capturing circulating tumor cells (CTCs) from blood is provided that includes a feedback control architecture that uses models of pump operation and measures of internal pressure fluctuations of the pump (e.g., in the form time-varying and/or position-dependent pressure oscillation data) to adjust pump operating characteristics that smooth pump operation, thereby improving viscosity and consistency of fluid flowing through the pump to a connected microfluidic capture device.

A system includes a charger and a cracker. An antiviral may be delivered through the charger. The cracker may include a first section and a second section to control the flow of the antiviral from the charger. The first section may receive the charger. The first section and the second section may be coupled together by using screw threads on the first and second sections. The cracker is configured to regulate the flow of antiviral into the user. The antiviral within the charger may include oxygen (O2) and nitrous oxide (N2O). Specifically, the antiviral may a mixture including 75% N2O and 25% O2 that inactivates the DNA and/or RNA of viruses, viroids, and germs.

Some embodiments provided herein relate to methods, systems and kits for providing consistent intracoronary administration of a biologic to subjects having diverse coronary anatomies. In some embodiments, the biologic is an adeno-associated virus serotype 1 (AAV1) vector encoding sarcoplasmic/endoplasmic reticulum ATPase 2a (SERCA2a) protein.

A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on cornea of an eye, in which the miniaturized needles penetrates into the eye; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect.

The device described herein converges the plasma separation function of a hollow-fiber plasmapheresis device with a formulation or cocktail of two or more adsorbent components housed in the extra-lumen space (outside the fiber walls, yet inside the outer shell of the plasmapheresis device) to optimize the adsorption of viral pathogens, shed viral proteins and viral exosomes (collectively known as the Viral Targets) in a low-shear force environment without interacting with blood cells.