A skin treatment device includes a control unit and a hand tool. The hand tool includes a body, a wiper head, and a needle roller head. The wiper head includes a rotatable wiper structure including one or more wiper blades. The needle roller head includes needle roller structure. The skin treatment device provides a multi-step process including desincrustation, skin transdermal delivery of topical agents, serums, and the like, microdermabrasion, and fractional micro-channeling application.

A method for forming an applicator comprises steps of: creating a digital geometric representation of the structure, the target structure having a flatness ratio; forming the applicator using the digital geometric representation of the target structure, the applicator having a target structure contacting surface; and disposing an active agent upon the target structure contacting surface of the applicator.

The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.

Method for targeted application of active agents to a target surface including: creating a digital geometric representation of the target surface; providing an array of applicators; selecting an applicator from the array of applicators based on the target surface; disposing the active agent on the applicator surface of the applicator; disposing the applicator on the target surface so that the active agent is in contact with the target surface; and removing the applicator from the target surface while leaving at least some of the active agent in contact with the target surface.

Described herein are drug and other active agent transdermal delivery systems and devices to deliver active agents to skin or mucosa of a subject, and methods of delivering such active agents. In particular, systems, methods, and devices are described that control the concentration and timing of active agent delivery. Such systems or devices may include a transdermal membrane and a temperature control element for heating and/or cooling a portion of the transdermal delivery system to provide pulsatile active agent delivery through the transdermal membrane.

The present disclosure relates to compositions, methods of use and methods of manufacturing of transdermal delivery systems, patches, vehicles and devices including an iontophoretic transdermal delivery system, patch, vehicle or device used to relieve pain (i.e., analgesics) and/or inflammation that contain a pharmaceutically effective amount of a pharmaceutically acceptable and effective cannabinoid and menthol.

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.

Presented herein are techniques for clinical-based automated control of the delivery of treatment substances to at least one inner ear of a recipient of an implantable medical device. More specifically, in-vivo biomarkers are analyzed to determine a biological state/status of one or more physiological elements of the inner ear. Subsequent delivery of one or more treatment substances to the inner ear of the recipient are controlled based on the determined biological state of the one or more physiological elements of the inner ear.

The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.

Method for targeted application of active agents to a target surface including: creating a digital geometric representation of the target surface; providing an array of applicators; selecting an applicator from the array of applicators based on the target surface; disposing the active agent on the applicator surface of the applicator; disposing the applicator on the target surface so that the active agent is in contact with the target surface; and removing the applicator from the target surface while leaving at least some of the active agent in contact with the target surface.