A device for targeted delivery of a substance to an airway may include a conduit and at least two applicators. The conduit may include a proximal end and a bifurcated distal portion having two distal ends. Each applicator may be coupled with one of the distill ends of the conduit and may be configured to direct the substance out of the applicator toward one of two sides of an airway. A method for targeted delivery of a substance to an airway may involve advancing a substance delivery device into the airway, contacting two sides of the airway with at least two applicators of the substance delivery device, such that each applicator contacts the airway near a glossopharyngeal nerve and/or a superior laryngeal nerve on each of the two sides of the airway, and delivering the substance through the applicators to contact the airway along the two sides.

A device and method for providing mechanical ventilation of a user is described. In an embodiment the device comprises at least two metallic coils, each coil configured to be placed adjacent to a phrenic nerve of the user; and a stimulation unit for providing an electric current to the metallic coils, and wherein the current stimulates the phrenic nerve to induce tetanic contractions of a diaphragm muscle of the user to regulate the user's breathing. This provides a ventilation whilst reducing the rehabilitation time post ventilation for a user due to lower muscle wasting of the diaphragm.

An iontophoresis system includes a preloaded reservoir containing one or more doses of a therapeutic agent. As a result, the therapeutic agent does not have to be loaded into the reservoir prior to use. In such a system, the preloaded reservoir is generally disposable. Various components of the iontophoresis system can be combined with the reservoir in a disposable cartridge that is selectively connectable to other, reusable components of the iontophoresis system. In addition, the entire iontophoresis system can be formed from one or more disposable, one-time-use modules.

A method for forming an applicator comprises steps of: creating a digital geometric representation of the structure, the target structure having a flatness ratio; forming the applicator using the digital geometric representation of the target structure, the applicator having a target structure contacting surface; and disposing an active agent upon the target structure contacting surface of the applicator.

A system for stimulating body tissue may include a stimulation lead, sensors, and a control unit. The stimulation lead may include one or more energy sources. The control unit may include a processor and non-transitory computer readable medium, and an interface (e.g., touch screen interface) for receiving user inputs and communicating information to the user. The sensors may be configured to provide impedance measurements to the control unit. The control unit may calculate lung gas distributions and/or generate an image modeling lung gas distributions. Stimulation delivered by the stimulation may be adjusted based on the impedance measurements.

Disclosed herein is a device defining a generally closed volume therein, henceforth known as a “shuttle”, not permanently fixed to a probe or other surface inside the cryostat, into which gas and/or liquid—most preferably helium gas or liquid—can pass into or out of in a controlled and predictable manner. The passage of gas or liquid into the shuttle is preferably via a porous barrier so that sterile conditions can be maintained in the interior of the shuttle.

A system for stimulating body tissue may include a stimulation lead, sensors, and a control unit. The stimulation lead may include one or more energy sources. The control unit may include a processor and non-transitory computer readable medium, and an interface (e.g., touch screen interface) for receiving user inputs and communicating information to the user. The sensors may be configured to provide impedance measurements to the control unit. The control unit may calculate lung gas distributions and/or generate an image modeling lung gas distributions. Stimulation delivered by the stimulation may be adjusted based on the impedance measurements.

Devices and methods for generating and applying stimulated acupuncture needles to one or more acupuncture points on a body of an individual suffering from one or more ailments using magnetic fields. The acupuncture device is configured for generating magnetic fields to stimulate acupuncture without using human manual manipulation. The acupuncture device may comprise a control unit and one or more acupuncture needle stimulation units. Each one or more acupuncture needle stimulation unit is functionally connected to the control unit by a cable or lead. The control unit may include a variable frequency generator configured to deliver various power levels, direct voltages, or a combination of various power levels and direct voltages to the acupuncture needle stimulation units, alone or in combination with other stimuli.

A neuromodulator may output stimuli that causes a user to fall asleep faster than the user would in the absence of the stimuli. Alternatively, the stimuli may modify a sleep state or behavior associated with a sleep state, or may cause or hinder a transition from a waking state to a sleep state or from a sleep state to another sleep state. The neuromodulator may take electroencephalography measurements. Based on these measurements, the neuromodulator may detect, in real time, instantaneous amplitude and instantaneous phase of an endogenous brain signal. The neuromodulator may output stimulation that is, or that causes sensations which are, phase-locked with the endogenous brain signal. In the course of calculating instantaneous phase and amplitude, the neuromodulator may perform an endpoint-corrected Hilbert transform. The stimuli may comprise auditory, visual, electrical, magnetic, vibrotactile or haptic stimuli.

A ventilation machine is disclosed that includes a conduit interface configured to be connected to a respiratory system of a human or animal patient, an air flow generator configured to deliver air through the conduit interface into the respiratory system of the patient, a processing unit in communication with the air flow generator and configured to control the airflow generator to deliver air into the respiratory system of the patient according to a breathing scheme, and an induction device for activating a diaphragm of the patient. The induction device is in communication with the processing unit. The processing unit is configured to control the induction device to activate the diaphragm in coordination with the breathing scheme.