The present disclosure provides an aerosol precursor consumable, and an aerosol delivery device that comprises a control unit that defines a receiving chamber, and a removable and replaceable aerosol precursor consumable, at least a portion of the consumable configured to be received into the receiving chamber. The aerosol precursor consumable comprises a housing defining an outer wall, an aerosol precursor composition reservoir located in the housing and configured to contain an aerosol precursor composition, an atomizer located in the housing, and at least one aroma diffuser. The atomizer is configured to vaporize the aerosol precursor composition to generate an aerosol for oral delivery to a user, and the at least one aroma diffuser is configured to diffuse an aroma composition for olfactory delivery to the user.

A bed includes components to control temperature of a sleep surface, for example based on time and historical usage patterns by a user. In some embodiments the temperature of the sleep surface is controlled based on information indicating a sleep state of the user. In some embodiments the temperature is dynamically adjusted so to achieve particular sleep states and/or sleep patterns for the user. In some embodiments the temperature and timing of temperature adjustments is iteratively adjusted over multiple sleep sessions so to achieve improvements in sleep states and/or sleep quality for the user.

A bed includes components to control temperature of a sleep surface, for example based on time and historical usage patterns by a user. In some embodiments the temperature of the sleep surface is controlled based on information indicating a sleep state of the user. In some embodiments the temperature is dynamically adjusted so to achieve particular sleep states and/or sleep patterns for the user. In some embodiments the temperature and timing of temperature adjustments is iteratively adjusted over multiple sleep sessions so to achieve improvements in sleep states and/or sleep quality for the user.

A breathing treatment delivery device is disclosed for providing atomized medicine or oxygen to a patient. The breathing treatment delivery device can include a supply device configured to dispense atomized medicine or oxygen through a dispensing end of the supply device. A cap can have a device side and a delivery side, the device side including an opening receiving and in fluid communication with the dispensing end of the supply device. A treat holder can be positioned on the delivery side of the cap. At least one aperture can be defined in the delivery side of the cap adjacent the treat holder, a pneumatic passage formed through the cap between the opening in the device side of the cap and the aperture. A patient can enjoy a piece of candy or other treat retained by the treat holder during treatment while breathing in the desired medicine or oxygen.

A hydrogen-containing gas supply system includes one or more hydrogen-containing gas suppliers, one or more acquirers, and a controller. The one or more hydrogen-containing gas suppliers supply a hydrogen-containing gas to one or more areas in a building. The one or more acquirers acquire information indicating that a person is present in the one or more areas. When it is determined that a person is present in a certain area of the one or more areas in accordance with the information acquired by the acquirers, the controller causes at least one of the one or more hydrogen-containing gas suppliers to supply the hydrogen-containing gas to the certain area.

A method is provided that includes intranasally dispensing nasal wash fluid into a nasal cavity of a subject such that the nasal wash fluid washes biological material into an oropharynx of the subject from (a) the nasal cavity, (b) a nasopharynx of the subject, or (c) the nasal cavity and the nasopharynx. The method further includes, thereafter, collecting a specimen sample that passed out of an anterior opening of an oral cavity of the subject and contains at least a portion of the biological material washed into the oropharynx by the nasal wash fluid. Thereafter, information is derived from extracellular vesicles present in the specimen sample. Other embodiments are also described.

An electrically-powered inhalation device for delivery of an aerosol to the oropharynx of a user comprises respective proximal and distal portions, the proximal portion including an inlet for a liquid, the distal portion including an aerosol outlet defining a mist-exiting location and a piezo assembly including an ultrasonically vibrable mesh membrane, for producing, upon electrical activation, a mist comprising droplets of the liquid, the mesh membrane defining a mist-generating location; and an intermediate portion disposed distally from the proximal portion and proximally from the distal portion, wherein the distal portion is dimensioned to vertically span the user's oral cavity from tongue to hard-palate when the user's lips and/or teeth are transversely engaged with the intermediate portion, so as to place the mist-exiting location in fluid communication with the user's oropharynx.

Disclosed are novel compositions, devices, patches, systems and methods that are useful for estimating, determining, modulating and/or improving the sleep/wake and/or circadian phase of a subject (e.g., a human subject) by the dispensing of measured quantities of agents to a subject or into an environment of the subject and the continuous monitoring and/or tracking of the subject's consciousness (e.g., sleep/wake) patterns. In certain aspects, the compositions, devices, patches, systems and methods disclosed herein are capable of delivering one or more agents to a subject in response to measured consciousness patterns estimations and circadian phase estimations, thereby aligning the subject's circadian biology to the external environment and improving the quality and duration of sleep.

There can be provided a device configured to impart flavouring to an airstream admitted the device prior to the airstream reaching an aerosol generator of the device, the device thereby operable to deliver a flavoured aerosol from an outlet.

A system to generate a vapor from a liquid includes an electric heater and an elongate wick. The electric heater defines an interior void having an inner surface and a plurality of apertures, and it is formed of an electrically resistive material contained within a heat diffusing material. The elongate wick is formed of a durable elongate structure having a plurality of liquid-conducting features on the outer surface. At least a portion of the liquid-conducting features of the elongate wick proximate the first end engage at least a portion of the one inner surface of the electric heater and are capable of conducting a the liquid from a source proximate the second end of the wick along the outer surface of the elongate wick to the electric heater.