Systems, methods and apparatuses for aerosolizing all or substantially all plant matter, medications, flavors, smells, liquid and/or other material to be aerosolizing are disclosed. Embodiments of the invention comprise an aerosolization chamber sealed except for two or more conduits, a first conduit coupled to a source of fully or almost fully oxygenated gas, a heating element capable of heating the aerosolization chamber to a temperature above a combustion temperature, a second conduit configured to transport aerosolized gases and elements out of the chamber and, in one implementation, at least one valve positioned in the second conduit preventing the flow of atmospheric air into the vaporization chamber. In some instances, the first gas substantially clears the vaporization chamber of atmospheric air prior to reaching combustion temperature. A second gas containing oxygen may be intermixed with the vaporization gases and vaporized elements proximal to the combustion chamber.

The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.

The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. A container holds the therapeutic agent and a pressure source has pressurized fluid in selective fluid communication with at least a portion of the container. A catheter, in fluid communication with the container, has a lumen sized for delivery of the therapeutic agent to a target site. In one embodiment, a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1, and a regulated pressure of the pressurized fluid is between about 0.01 psi to about 100 psi.

A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.

A system includes a charger and a cracker. An antiviral may be delivered through the charger. The cracker may include a first section and a second section to control the flow of the antiviral from the charger. The first section may receive the charger. The first section and the second section may be coupled together by using screw threads on the first and second sections. The cracker is configured to regulate the flow of antiviral into the user. The antiviral within the charger may include oxygen (O2) and nitrous oxide (N2O). Specifically, the antiviral may a mixture including 75% N2O and 25% O2 that inactivates the DNA and/or RNA of viruses, viroids, and germs.

A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 μm, so as to target the pulmonary system of the user.

A system for creating separation between biological surfaces may comprise a hollow body configured for delivery of a fluid to a target location, a fluid supply in fluid-communication with the hollow body, a control element configured to control the delivery of a fluid through the hollow body, at least one first sensor configured to measure at least one parameter of the fluid flowing through the hollow body, at least one second sensor configured to measure at least one parameter of an environment of the hollow body, a feedback control module configured to receive information from one or more of the at least one first sensor or the at least one of the second sensor to control at least one operational function of the system.

Systems and methods for opening the eustachian tubes of a subject are provided. Aspects of the systems include: a swallow inducer; a nasal passage seal; a pressure source configured to apply positive pressure to a sealed nasal passage; a sensor configured to detect a parameter indicative of a swallow resultant palate closure; and a controller operably coupled to the pressure source and the sensor, wherein the controller is configured to cause the pressure source to apply positive pressure to a sealed nasal passage upon detection by the sensor of the parameter indicative of a swallow resultant palate closure. Also provide are methods of using the systems to open eustachian tubes. The systems and methods find use in a variety of different applications, e.g., the treatment of a subject for Otitis Media with Effusion (OME).

A wearable device for providing haptic stimulations is provided. The wearable device includes: (i) a wearable structure to be worn on a portion of a user's body and (ii) an inflatable bladder, coupled to the wearable structure, that includes two or more pockets positioned at a target location on the wearable structure. Furthermore, the two or more pockets are configured to, when inflated, impart directional force(s) onto the user at the target location that impede movement of the portion of the user's body. Additionally, the directional force(s) are caused by the two or more pockets interfering with each other, when inflated. In some embodiments, (a) the portion of the user's body is a hand of the user, (b) the target location is a finger joint on the user's hand, and (c) the directional force(s) imparted onto the user at the target location impede flexion of the user's finger.

A system suitable for delivering a therapeutic agent to a target site may include a container for holding a therapeutic agent; a pressure source having pressurized fluid, the pressure source in selective fluid communication with at least a portion of the container; a catheter in selective fluid communication with the container and configured for delivery of the therapeutic agent or the pressurized fluid to a target site; and a housing configured to securely retain the container and movably support a switch, where the switch is movable between a first position and a second position, where when the switch is in the first position, delivery of the therapeutic agent is prevented while delivery of the pressurized fluid is permitted, and where when the switch is in the second position, delivery of the therapeutic agent is permitted.