The present invention aims to provide a method for producing a microneedle device comprising a coating comprising dexmedetomidine and isoproterenol, in which the stability of isoproterenol during production and after production of the microneedle device is high. A method for producing a microneedle device according to one embodiment of the present invention comprises coating microneedles with a coating liquid to form a coating on the microneedles. The microneedle device comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles. The coating liquid comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, isoproterenol or a pharmaceutically acceptable salt thereof, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, and a sulfated polysaccharide.

The present invention relates to the field of cancer therapy. In particular, the present invention relates to a method of preventing, treating or inhibiting the development of tumours and/or metastases in a subject by administering one or more immunomodulators into the skin via a microneedle device.

The present invention relates to a cosmetic process for a keratin substance such as the skin or the lips, comprising the steps of: applying onto the keratin substance at least one composition comprising at least one coloring agent; and applying onto the keratin substance, to which the composition has been applied, a microneedle sheet comprising a substrate sheet and a plurality of microneedles on the substrate sheet such that the microneedles are capable of penetrating into the keratin substance. According to the present invention, microneedles can penetrate into a keratin substance to provide the keratin substance with long lasting and uniform color effects.

A wearable device 100 for managing alcohol-driven violence is disclosed. The device 100 comprises a capsule C1 adapted to sense sweat of wearer and detect a level of alcohol in the sweat, a capsule C3 adapted to convert a data detected by the capsule C1 to generate signal activating a capsule C4, a capsule C2 adapted to provide power to the capsule C3, and a capsule C5 adapted to detect a muscle activity of the wearer, wherein the capsule C4 is adapted to inject a drug into the body of the wearer, when activated, and wherein the capsule C5 alerts authorities when no muscle activity is detected.

A packaging system for microarrays, such as microarrays of microneedles, comprising inner and outer pouches (500, 5000).

The present disclosure relates to a method for manufacturing a microneedle containing a coating part on a needle tip and an apparatus used for the method. When a microneedle is manufactured using the coating method and apparatus according to the present disclosure, a coating part in which a target material is impregnated can be easily inserted into skin and effective dissolution is possible. Further, the target material is allowed to show excellent skin permeability with the dissolution of the coating part of the microneedle manufactured according to the present disclosure, thereby a quantitative amount of target material can be effectively delivered into the skin.

An application device for a fluid delivery includes a housing having a bore extending from a bottom of the housing. The bore is sized and shaped for receiving at least a portion of the fluid delivery apparatus. The application device also includes an impact component for impacting the fluid delivery apparatus and moving at least a portion of the fluid delivery apparatus towards a user's skin. The application device includes a safety arm that is positionable relative to the impact component between a locked configuration in which the impact component is secured in a safety position, and a released configuration in which the impact component is free to move within the housing for impacting the fluid delivery apparatus.

The present invention relates to a skin administration system capable of improving the efficiency of skin delivery of an ingredient for controlling release of neurotransmitters and, particularly, to a microneedle containing an ingredient for controlling release of neurotransmitters.

There is provided an ascension aid for a wind turbine comprising a cabin, a catch unit which co-operates with a securing cable as a securing means and a testing unit for testing the functionality of the catch unit. The testing unit has a base plate, a closure counterpart holder, a closing member and an actuating element coupled to the closing member. By actuation of the actuating element the closing member and the closure counterpart holder clamp the securing cable and the closing member and the closure counterpart holder move upwardly along the base plate. Upon release or de-activation of the actuating element the closing member releases the securing cable and the catch unit trips.

The present invention relates to a method of a method of measuring a human body analyte concentration in an interstitial fluid, comprising the step of measuring a first electrical current I.sub.1 between a working electrode and a pseudo-reference electrode while applying a first potential between the working electrode and the pseudo-reference electrode, the first potential being less than a threshold potential, the magnitude of the first electrical current being greater than the magnitude of a predetermined first threshold current, and further measuring an output electrical current between the working electrode and the pseudo-reference electrode while applying a second electrical potential, the second electrical potential being greater than the first electrical potential.