Methods and devices for accurately pumping small quantities of liquid to a patient with a broad range of flow and low cost.

In one embodiment, a fluid storage device includes a rigid outer housing that defines a septum cavity, a reservoir cavity, and a channel that extends between the two cavities, the outer housing further defining an outlet in fluid communication with the reservoir cavity, a septum provided within the septum cavity, the septum being made of an elastic polymer and facilitating refilling of the fluid storage device, and a thin, collapsible membrane that does not generate significant restoring forces when it is deformed as fluid is drawn from the reservoir cavity and, therefore, does not completely or partially return to its initial non-deformed shape even if the outlet of the device remains open after doses are administered.

Methods and devices for accurately pumping small quantities of liquid to a patient with a broad range of flow and low cost.

A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.

An implantable medical device having a soft tissue interfacing surface comprises at least one soft actuatable capsule having a soft tissue interfacing deflectable membrane configured for cyclical deflection upon actuation of the capsule to modulate the biomechanics of the soft tissue interface during use. The actuatable capsule may comprise an actuation chamber containing a first fluid, a therapeutic chamber containing a second fluid, a deflectable membrane separating the actuation chamber and therapeutic chamber, and an actuation conduit in fluidic communication with the actuation chamber for pneumatic actuation of the actuation chamber. The therapeutic chamber comprises the soft tissue interfacing deflectable membrane which is configured to cyclically deflect during actuation of the capsule and modulate the biomechanics of the soft tissue interface by altering one or more of strain, fluid flow and cellular activity in peri-implant tissue at the soft tissue interface. Methods of reducing fibrotic encapsulation of an implantable medical device are also described.

An elastomeric pump having at least one sensor for sensing changes in elongation of a bladder of the pump is provided. Also provided is an infusion assembly including an elastomeric pump having a bladder, at least one sensor for sensing changes in elongation of the bladder, and an indicator for providing one or more outputs of the sensor. The sensor may be a flexible sensor positioned in contact with the bladder of the pump, or a dielectric material may be incorporated into the material the bladder is made from such that the dielectric elastomer material of the bladder forms the sensor.

Embodiments of this invention relate to a fluid delivery device. The fluid delivery device comprises a fluid reservoir for containing a fluid, a first drive mechanism configured to remove a predetermined amount of the fluid from the fluid reservoir when the first drive mechanism is actuated, a needle, a septum and a housing having an orifice. Also disclosed is a method for dispensing a fluid from a fluid delivery device into a patient.

A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.

In one embodiment, a fluid storage device includes a rigid outer housing that defines a septum cavity, a reservoir cavity, and a channel that extends between the two cavities, the outer housing further defining an outlet in fluid communication with the reservoir cavity, a septum provided within the septum cavity, the septum being made of an elastic polymer and facilitating refilling of the fluid storage device, and a thin, collapsible membrane that does not generate significant restoring forces when it is deformed as fluid is drawn from the reservoir cavity and, therefore, does not completely or partially return to its initial non-deformed shape even if the outlet of the device remains open after doses are administered.

Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made during a “priming” stage when liquid is pumped through the internal fluid path but does not exit the pump.