An autoinjector including a housing; an axially fixed product container; a torsion spring; a drive element; a propulsion element; and a needle protection sleeve is configured such that when the autoinjector is pressed against an injection location, the needle protection sleeve undergoes an actuation movement in the proximal direction. For discharging liquid from the product container through an injection needle into the injection location, the torsion spring sets the drive element into rotation and the rotating drive element causes a movement of the propulsion element and a piston in the product container in the distal direction. The autoinjector includes a coupling which, due to the actuation movement of the needle protection sleeve, releases the drive element for rotation, where the coupling is between a first and second coupling element in an engagement of locking surfaces, and can be disengaged by an axial coupling stroke of the two coupling elements.

A system for delivering an injection of a fluid into a void within a subject is disclosed. A barrel extends from a first end to a second end and forms a lumen extending from the first end to the second end. A plug and a floating seal are arranged within the lumen. A hollow needle includes a distal end with an opening for fluid to flow from the lumen. The plug, the barrel and the floating seal include material and dimensions selected based on a threshold flowrate for a fluid arranged within the lumen to: overcome a force opposed to a force being applied to the fluid in the lumen to move the floating seal and the hollow needle into a tissue of the subject, and succumb to the opposing force to displace the fluid through the opening into the void.

An automatic injection device includes an end sleeve and a syringe support mounted slidably with respect to the end sleeve. The syringe support is intended to carry an injection syringe provided with an injection needle and with a cap for protecting the injection needle. The automatic injection device includes a membrane formed by at least two locking elements which are mounted so as to slide substantially radially in the end sleeve between a configuration permitting passage of the cap for protecting the injection syringe, in which configuration limit stops of the at least two locking elements, intended to cooperate with a shoulder of the injection syringe, are moved away from each other, and a configuration permitting immobilization of the injection syringe, in which configuration the limit stops of the at least two locking elements are moved towards each other.

The disclosure relates to systems, methods and apparatus of storing, transporting, mixing, and injecting a drug as a solution, and in some embodiments, to a drug injection apparatus and system intended for use in mixing on demand a drug with a liquid, such as water, in a premeasured quantity and dosage, and injecting the drug mixture using an integrated hypodermic needle assembly. Also provided are methods of using such apparatus and systems.

The present invention provides a two-step auto-injection apparatus consisting of a housing, a protective sleeve cylinder, a pre-filled injection assembly and a drive feedback apparatus, wherein the pre-filled injection assembly is loaded into the housing, and the protective sleeve cylinder covers a needle of the pre-filled injection assembly, so that the protective sleeve cylinder directly contacts an injecting portion and the function of injection can be realized by pressing to trigger the drive feedback apparatus during use, thereby facilitating quick operation with a needle tip hidden in the whole process; the drive feedback apparatus of a piston in a needle cylinder is driven to combine a release mechanism with an ejection mechanism and a feedback mechanism, and the release mechanism is triggered by pressing the protective sleeve cylinder, so that the ejection mechanism is released, and the ejection mechanism interacts with the feedback mechanism in a form of collision, for example, to generate a sound signal and/or a haptic signal in the moment of release for prompting a patient to begin an injection; when the ejection mechanism finishes movement, the ejection mechanism interacts again with the feedback mechanism in the form of collision, for example, to generate the sound signal and/or the haptic signal for promoting the patient to finish the injection.

An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

The invention relates to a piston rod drive arrangement for an injection device used for self-administration of a plurality of individually set doses. The drive arrangement is made from a first element (10) mating the non-circular cross-section (3) of a piston rod (1) and a second element (20) having an inner thread (21) mating the outer thread of the piston rod. Whenever the first element (10) and the second element (20) are rotated in relation to each other the piston rod (1) is moved in an axial direction. In order to minimise the play in the threaded connection a resilient element (23) is proved to apply a force to the piston rod (1) in a longitudinal direction.

In selected embodiments, a handheld injection safety applicator (100) includes an applicator housing with a handle (104) and a retractable needle (106) housed within the applicator. The applicator further includes a first sensor (112) that detects the presence of a user's grip on the handle and a second sensor (118) that detects the presence of an animal. The applicator also includes processing circuitry configured to receive a first signal from the first sensor indicating that the user is gripping the handle and receive a second signal from the second sensor indicating that an animal is detected. The applicator extends the needle out of the applicator into the animal once the first and second signal are received and delivers a dose of medication into the animal once the needle is fully extended into the animal.

An injection needle assembly (50) for an injection device, comprising: a) a needle cannula (3) attached to a needle hub (4) and defining a pointed tip at a free end (3a, 3b), and b) a needle cover (10, 10a, 10b) forming an axially extending elongated flexible enclosure accommodating the needle cannula (3). The needle cover (10, 10a, 10b) is configured to axially collapse and become penetrated by the needle cannula (3) when a penetration force is applied to the needle cover. The needle cover (10, 10a, 10b) defines a shaft section (11a) and a bulb section (11b). The shaft section (11a) encircles the needle cannula (3) and extends axially from the needle hub (4) to the bulb section (11b). The shaft section (11a) comprises a collapsible wall area (15) having wall thickness t.sub.1 less than a predefined wall thickness t.sub.1,lim to provide radial deformability for abutting contact with the needle cannula (3). The bulb section (11b) comprises a wall area (17a, 17b) having a wall thickness t.sub.2 being greater than said predefined wall thickness t.sub.1,lim, and further defines a central end wall area (20) having a wall thickness t.sub.3 smaller than the wall thickness t.sub.2. In an initial non-penet-rated state, the needle cover (10, 10a, 10b) assumes a first configuration wherein the wall areas of the bulb section (11b) and the wall areas of the shaft section (11a) are spaced apart from the needle cannula (3).

An injection device for injecting medicament in a patient comprises a housing configured to house a fluid reservoir that has one of a plurality of volumes of medicament. An injection conduit fluidly coupled to the fluid reservoir defines a fluid pathway from the fluid reservoir to the patient. A firing mechanism is coupled to the fluid reservoir and is configured to expel the medicament from the fluid reservoir through the injection conduit. A volume setting mechanism is coupled to the firing mechanism and is configured to select the one of the plurality of volumes of medicament for the firing mechanism to expel. A dose setting mechanism is configured to select all or a fraction of the one of the plurality of volumes of medicament that is injected from the injection conduit when the firing mechanism is actuated.