A system for delivering an injection of a fluid into a void within a subject is disclosed. A barrel extends from a first end to a second end and forms a lumen extending from the first end to the second end. A plug and a floating seal are arranged within the lumen. A hollow needle includes a distal end with an opening for fluid to flow from the lumen. The plug, the barrel and the floating seal include material and dimensions selected based on a threshold flowrate for a fluid arranged within the lumen to: overcome a force opposed to a force being applied to the fluid in the lumen to move the floating seal and the hollow needle into a tissue of the subject, and succumb to the opposing force to displace the fluid through the opening into the void.

An injector device includes a housing and a cartridge having a reservoir for medicament. The injector device further includes a needle unit comprising a needle, and an actuator. The needle unit is movably mounted to the housing and, prior to use of the injector device the reservoir, is sealed from the needle. The actuator is configured to move the needle unit 5 into engagement with the cartridge such that the needle is moved into fluid communication with the reservoir. A thread is arranged to cause rotation of the needle unit as the needle unit moves into engagement with the cartridge.

Disclosed are introducer components, assemblies, and methods. For example, an introducer assembly can include a syringe and a needle assembly fluidly connected thereto. The needle assembly can include a needle and an access guidewire-advancement mechanism mounted on a proximal linear portion of a needle shaft of the needle. The needle shaft can include a sigmoid portion between a distal linear portion of the needle shaft and the proximal linear portion as well as a port in a transition from the sigmoid portion to the distal linear portion of the needle shaft. An access guidewire can be loaded in both the access guidewire-advancement mechanism and a needle-shaft lumen in the distal linear portion of the needle shaft in a ready-to-deploy state of the introducer assembly. In this way, the access guidewire can be immediately advanced into a blood-vessel lumen upon establishing a needle tract thereto with the needle.

Disclosed are introducer components, assemblies, and methods. For example, an introducer assembly can include a fluidly connected syringe and needle. The needle can include a needle shaft and a needle hub over a proximal portion of the needle shaft. The needle hub can include a port and a valve disposed in the port. The port can be in a side of the needle hub proximal of a proximal end of the needle shaft. The valve can be configured to form a fluid-tight seal around an elongate medical device such as an access guidewire when passed through the port and into a needle-hub lumen of the needle hub. Such an access guidewire can be disposed in the introducer assembly just proximal of a needle tip of the needle. In this way, the access guidewire can be immediately advanced into a blood-vessel lumen upon establishing a needle tract thereto with the needle.

The present disclosure relates to relates to medication injection devices, and in particular to systems and methods for on-demand delivery of a non-liquid medication from a wearable medication injection device. Particularly, aspects of the present invention are directed to a device that includes a housing defining a chamber, a piston disposed within the chamber, a needle disposed within the chamber on a first side of the piston, an energetic material disposed within the chamber on a second side of the piston, and a medication strip disposed within the needle. The medication strip includes an injectable substance in a non-liquid form.

A body-insertion device for a body includes an adjustment unit for adjusting bevel orientation of a needle, and a moving unit for the needle. The moving unit supports a needle unit having the needle, the bevel orientation of which is adjusted by the adjustment unit; adjusts the needle unit to the orientation which is appropriate for body-insertion; and moves the needle unit for body-insertion.

An accessory for an injection device having a safety shield and at least one flange adapted to allow a user to grip the injection device and a syringe sheath moveable relative to the at least one flange from a pre-injection position to a locked-out position. The accessory comprises a body portion comprising a recess adapted to receive the safety shield of the injection device and a slot adapted to receive the at least one flange of the injection device.

Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.

Described is a medicament delivery device (1), comprising a body (2), a container carrier (7) for retaining a medicament container within the body (2) and being slidably disposed in the body (2), a sleeve (6) slidably coupled to body (2), and a piston rod (11) coupled to the body (2) and the container carrier (7). The piston rod (11) and the container carrier (7) provide a feedback as 10 the container carrier (7) moves from a first position (P1) to a second position (P2) relative to the body (2).

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent.