A blood pump system is implantable in a patient for ventricular support. A pumping chamber has an inlet for receiving blood from a ventricle of the patient. An impeller is received in the pumping chamber. A motor is coupled to the impeller for driving rotation of the impeller. A motor controller is provided for tracking systolic and diastolic phases of a cardiac cycle of the patient and supplying a variable voltage signal to the motor in a variable speed mode to produce a variable impeller speed linked to the cardiac cycle. The impeller speed comprises a ramping up to an elevated speed during the diastolic phase in order to reduce a load on the ventricle at the beginning of the systolic phase.

A control circuit for a sensorless implantable blood pump configured to determine mitral valve regurgitation includes processing circuitry configured to generate an estimated blood flow waveform from the sensorless implanted blood pump and generate an alert if between an end period of diastole and a beginning period of systole a measured amplitude of the estimated blood flow waveform does not include an inflection point.

A control circuit for a sensorless implantable blood pump configured to determine mitral valve regurgitation includes processing circuitry configured to generate an estimated blood flow waveform from the sensorless implanted blood pump and generate an alert if between an end period of diastole and a beginning period of systole a measured amplitude of the estimated blood flow waveform does not include an inflection point.

The present disclosure relates to a motor for an extracorporeal blood pump, an extracorporeal blood pump, and an extracorporeal blood pump system. The motor for an extracorporeal blood pump comprises: a housing; an actuator located in the housing and used for driving an impeller in a pump head of the extracorporeal blood pump; at least one sensor located in the housing; and a motor driving-control assembly located in the housing and used to control operation of the motor. Integrating the motor driving-control assembly into the housing of the motor can significantly reduce the dependence of the motor on the control host of the extracorporeal blood pump, the risk of communication failure between the motor and the control host, and the risk of malfunction of the motor driving-control assembly, thereby greatly improving the safety and reliability of the extracorporeal blood pump.

Various embodiments of a system for priming a catheter assembly are disclosed herein. For example, the system can include a catheter assembly including an elongate body and an operative device coupled thereto. The system can also include a priming vessel configured to receive insertion of the operative device therein. The priming vessel can include a proximal portion secured to the distal portion of the elongate body such that the elongate body is in fluid communication with the priming vessel. The priming vessel can also include a distal end through which air is expelled when a fluid is channeled through the elongate body and into the priming vessel to expel air from within the catheter assembly.

Methods and systems are disclosed for creating and using a neural network model to estimate a cardiac parameter of a patient, and using the estimated parameter in providing blood pump support to improve patient cardiac performance and heart health. Particular adaptations include adjusting blood pump parameters and determining whether and how to increase or decrease support, or wean the patient from the blood pump altogether. The model is created based on neural network processing of data from a first patient set and includes measured hemodynamic and pump parameters compared to a cardiac parameter measured in situ, for example the left ventricular volume measured by millar (in animals) or inca (in human) catheter. After development of a model based on the first set of patients, the model is applied to a patient in a second set to estimate the cardiac parameter without use of an additional catheter or direct measurement.

Methods and systems are disclosed for creating and using a neural network model to estimate a cardiac parameter of a patient, and using the estimated parameter in providing blood pump support to improve patient cardiac performance and heart health. Particular adaptations include adjusting blood pump parameters and determining whether and how to increase or decrease support, or wean the patient from the blood pump altogether. The model is created based on neural network processing of data from a first patient set and includes measured hemodynamic and pump parameters compared to a cardiac parameter measured in situ, for example the left ventricular volume measured by millar (in animals) or inca (in human) catheter. After development of a model based on the first set of patients, the model is applied to a patient in a second set to estimate the cardiac parameter without use of an additional catheter or direct measurement.

Systems and methods for deriving pressures outside of a blood inlets and blood outlets of an intracardiac blood pump assembly, and pressure differentials therebetween. Pressures outside of a blood inlet may be derived based on one or more readings from a pressure sensor placed within a blood inlet, one or more readings from a differential pressure sensor configured to measure pressure differential across a wall of the pump housing or cannula, and speed of the pump motor. Pressure differentials between a blood inlet and blood outlet may be derived based on one or more readings from the differential pressure sensor and speed of the pump motor. Pressures outside of a blood outlet may be derived based on a derived pressure outside of a blood inlet and a derived pressure differential between the blood inlet and the blood outlet.

The present invention provides an intravascular blood pump comprising an impeller housing and/or impeller blade(s) that may be expandable and collapsible. The blade(s) and/or impeller housing may be biased to expand or may be expanded by centrifugal forces generated during rotation of the impeller and blades with an operatively connected rotational motor.

The present invention provides an intravascular blood pump comprising an impeller housing and/or impeller blade(s) that may be expandable and collapsible. The blade(s) and/or impeller housing may be biased to expand or may be expanded by centrifugal forces generated during rotation of the impeller and blades with an operatively connected rotational motor.