An apparatus includes a rigid body, a flexible sealing element, a nozzle assembly, and an electrode. The rigid body defines a channel, a reservoir, and a vent path. The reservoir is in fluid communication with the channel. The vent path is in fluid communication with the reservoir. The reservoir is configured to provide spacing between the channel and the vent path. The sealing element is positioned distal to the rigid body. The nozzle assembly includes a nozzle head and a post. The post extends distally through the channel of the rigid body. The nozzle head projects distally from a distal end of the post. The electrode is disposed within the channel of the rigid body. The reservoir extends laterally from a longitudinal axis defined by the electrode.

An apparatus includes a rigid body, a flexible sealing element, a nozzle assembly, and an electrode. The rigid body defines a channel, a reservoir, and a vent path. The reservoir is in fluid communication with the channel. The vent path is in fluid communication with the reservoir. The reservoir is configured to provide spacing between the channel and the vent path. The sealing element is positioned distal to the rigid body. The nozzle assembly includes a nozzle head and a post. The post extends distally through the channel of the rigid body. The nozzle head projects distally from a distal end of the post. The electrode is disposed within the channel of the rigid body. The reservoir extends laterally from a longitudinal axis defined by the electrode.

Residual, refractory or relapsed cancer is treated by immunostimulation in the presence of allogeneic immune effector cells, optimally in combination with radiation therapy. The methods of the disclosure induce a systemic allogeneic anti-tumor immune response that results in tumor regression in untreated sites of disease, i.e. non-injected, non-irradiated, etc.

Residual, refractory or relapsed cancer is treated by immunostimulation in the presence of allogeneic immune effector cells, optimally in combination with radiation therapy. The methods of the disclosure induce a systemic allogeneic anti-tumor immune response that results in tumor regression in untreated sites of disease, i.e. non-injected, non-irradiated, etc.

The present invention relates to a method for inducing a controlled fluid transport in a central nervous system, CNS, and/or in a cerebrospinal fluid, CSF system, of a patient by electro-osmosis, EO, via two or more electrodes placed at selected locations on the patients head, comprising receiving EO information, the EO information being at least indicative of fluid transport response resulting from application of particular electric potentials and/or currents at particular electrode locations on the patient's head based on a patient-specific three-dimensional head model, receiving a fluid source location within the patient's head, selecting a set of electrode locations using the EO information and the fluid source location, placing the two or more electrodes in electrical communication with said CNS/CSF-system, each electrode being placed at one location of the selected set of electrode locations, and controlling an application of selected electric potentials and/or electric currents to said electrodes, wherein the selected electric potentials and/or electric currents is selected as electric potentials and/or electric currents associated to the selected set of electrode locations by the EO information, so as to induce a controlled fluid transport in said CNS/CSF-system.

The present invention relates to a method for inducing a controlled fluid transport in a central nervous system, CNS, and/or in a cerebrospinal fluid, CSF system, of a patient by electro-osmosis, EO, via two or more electrodes placed at selected locations on the patients head, comprising receiving EO information, the EO information being at least indicative of fluid transport response resulting from application of particular electric potentials and/or currents at particular electrode locations on the patient's head based on a patient-specific three-dimensional head model, receiving a fluid source location within the patient's head, selecting a set of electrode locations using the EO information and the fluid source location, placing the two or more electrodes in electrical communication with said CNS/CSF-system, each electrode being placed at one location of the selected set of electrode locations, and controlling an application of selected electric potentials and/or electric currents to said electrodes, wherein the selected electric potentials and/or electric currents is selected as electric potentials and/or electric currents associated to the selected set of electrode locations by the EO information, so as to induce a controlled fluid transport in said CNS/CSF-system.

A medicine administration tool configured for use in a transocular iontophoresis device for forming an electric circuit between a first electrode and a second electrode and supplying medicine to an eyeball, includes: a tubular member having a first lower end configured to face the eyeball; an inner member having a second lower end configured to face the eyeball, the inner member being accommodated in a space of the tubular member and forming a medicine accommodating chamber for accommodating the medicine between the inner member and the tubular member; and a support member movably supporting the inner member with respect to the tubular member.

The present invention is directed to a method and apparatus for an electrotherapeutic system including a first and second electrode. Each electrode includes a respective resistance wherein during operation of the electrotherapeutic system, an electrochemical reaction involving one or both of the electrodes varies the respective resistance of at least one of the electrodes.

The present invention is directed to a method and apparatus for an electrotherapeutic system including a first and second electrode. Each electrode includes a respective resistance wherein during operation of the electrotherapeutic system, an electrochemical reaction involving one or both of the electrodes varies the respective resistance of at least one of the electrodes.

Provided is a skin care device including a head part brought into contact with skin of a user, a battery configured to supply power for operation of the head part, a body part having a fastening portion provided at one end to which the head part is fastened and provided with the battery therein, and a cap assembly detachably attached to one end of the body part and forming an accommodation space configured to accommodate the head part, wherein the cap assembly includes a sterilization module disposed to irradiate ultraviolet light toward the head part when the cap assembly accommodates the head part.