Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.

Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.

An intelligent bioelectric module for use with a drug delivery system has a case and a set of at least two electrodes in electrical communication with a detection surface of the case. The case is configured so that, in use, the detection surface comes into electrical communication with (i) a second surface of the delivery system when a first surface of the delivery system has been put into contact with a tissue surface of a human or animal subject or (ii) the tissue surface that is adjacent to a portion contacted by the first surface of the delivery system or (iii) both the second surface and the tissue surface.

Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.

The invention is broadly directed to a skin care apparatus comprising: a camera; a light device for emitting at least one of a blue, a green, a yellow and a red light; a vibration pad; a heating element; a heat sensor; a skin moisture sensor; an iontophoresis module; and a control processor configured to: operate the camera and the skin moisture sensor to perform a skin quality assessment of a user's skin, and operate any one or more of: the light device, the vibration pad, the heating element, the heat sensor, and the iontophoresis module to provide a bespoke skin treatment for the user's skin based on the skin quality assessment.

The present disclosure relates to relates to systems and methods for on-demand delivery of a therapeutic agent from an eye mounted device. Particularly, aspects of the present invention are directed to a method of delivering a therapeutic agent, the method including receiving, at a controller of a therapeutic agent release and delivery device, a first command signal for delivery of a therapeutic agent based on a dosing time window. Upon receipt of the first command signal, the controller determines whether one or more compliance conditions are satisfied. When the one or more conditions are satisfied, the controller initiate a release and delivery protocol that commands a signal generator to generate and send a second command signal causing a capacitor or one or more circuits to deliver an actuation signal causing one or more therapeutic agent delivery mechanisms to open and release the therapeutic agent from one or more reservoirs.

A skin care device according to an embodiment of the present disclosure includes a substrate; a case for covering surface of the substrate; and at least one galvanic current application device electrically connected to the substrate, in which each of the at least one galvanic current application device includes a contact head that forms a contact surface with respect to a user's skin and is electrically connected to the substrate; and a holder provided between the substrate or the case and the contact head, and in which the holder includes an elastic fixing body elastically fixing the contact surface of the contact head to a position spaced apart from the case by a predetermined length.

A reverse electrodialysis device using a precipitation reaction, according to one embodiment of the present invention, comprises a first cell stack alternately forming solid salt chambers and precipitation chambers through cation-exchange membranes and anion-exchange membranes which are alternately provided, and a first water-soluble solid salt and a second water-soluble solid salt which are filled in the solid salt chambers, wherein the first water-soluble solid salt and the second water-soluble solid salt are alternately filled in the solid salt chambers, and can react with each other so as to generate a precipitate in neighboring precipitation chambers when water is supplied.

A reverse electrodialysis device using a precipitation reaction, according to one embodiment of the present invention, comprises a first cell stack alternately forming solid salt chambers and precipitation chambers through cation-exchange membranes and anion-exchange membranes which are alternately provided, and a first water-soluble solid salt and a second water-soluble solid salt which are filled in the solid salt chambers, wherein the first water-soluble solid salt and the second water-soluble solid salt are alternately filled in the solid salt chambers, and can react with each other so as to generate a precipitate in neighboring precipitation chambers when water is supplied.

A device (100) for electrophoretic delivery of ions comprising a source electrode (200) in electric and ionic contact with a source electrolyte (202), and a target electrode (400) in electric and ionic contact target electrolyte (402), said source and target electrodes (200, 400) capable of conducting ions and electrons; an ion-conductive channel (302) connecting the source electrolyte (202) with the target electrolyte (402) to provide an ionic connection between said source and said target electrodes (200, 400), wherein said electrodes (200, 400) and said ion-conductive channel (302) are formed of solid or semi-solid materials, and a controller, operable to apply a drive voltage between said source and said target electrodes (200, 400), such that at least after a voltage is applied across said ion-conductive channel, a potential difference between said source and target electrodes (200, 400) is provided, further comprising a trapping electrode (300) comprising an effective amount of a Bronsted base, said trapping electrode (300) being arranged in ionic contact with the ion-conductive channel (302). Use of the device is also disclosed, as is a method of operating the device and a method electrophoretic delivery of ions.