Systems and methods for destroying or inhibiting cancer cells and other rapidly-dividing cells include coupling an alternating polarity (AP) magnetic field generator to a target body area and applying an AP magnetic field having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to the target body area to achieve a desired inhibiting effect on cancer cells or other rapidly-dividing cells. Treatments provided by the system may be co-administered with an anti-cancer drug such as a chemotherapy drug, a hormone therapy drug, targeted therapy drugs, immunotherapy drugs, or an angiogenesis inhibitor drug.

The improvement of administration of a therapeutic agent to a targeted region of a patient's brain is herein described. A magnetic material, preferably soluble iron, is administered to the patient. A magnetic field, for example via transcranial magnetic stimulation (TMS), is applied to the targeted region of the patient's brain. The magnetic field is used to agitate magnetic material localized to the targeted region of the brain, temporarily forming openings in the blood-brain barrier (BBB), increasing local perfusion, or both at the targeted region. A therapeutic agent is administered to the patient and is delivered to the targeted region of the patient's brain through openings in the BBB, local perfusion, or both.

Systems and methods are provided to combine multiple stimulation modalities to significantly increase the effectiveness of non-invasive stimulation. Multiple sensor and stimulation devices and modalities can be combined into a single, compact unit that minimizes the need for additional sensors or stimulation devices. The system features several subunits, referred to as sensory and stimulation devices (SSD), that are integrated into a headphone setup. The system is controlled by a centralized controller that communicates with all of the SSDs and with an external computer system that delivers learning material synchronized with the delivery of stimulations and the collection of user responses based on physiological signals.

A method for treating conditions associated with thalamocortical dysrhythmia. The method includes applying transcranial low voltage electrical stimulation (TLVES) therapy or transcranial magnetic stimulation (TMS) therapy to a patient in need thereof, and administering to the patient a dissociative anesthetic during the TLVES therapy or the TMS therapy. A number of conditions including tinnitus, depression and pain can be treated with TLVES or TMS in combination with the dissociative anesthetic, such as an NMADR inhibitor, including ketamine.

A device is provided for the stimulation of neurons that includes a non-invasive stimulation unit to generate stimuli in multiple stimulation channels, where the stimulation unit stimulates a neuron population in the brain and/or spinal cord of a patient in different locations for each of the stimulation channels. Moreover, the device includes a control unit that controls the stimulation unit to generate repetitive bursts in each of the stimulation channels, where each of the bursts includes multiple stimuli and is designed so that they do not reset the phase of the neuronal activity of the respective stimulated neurons.

Embodiments of the present disclosure include a system for applying therapeutic pressure to a skin surface including a tip arranged at a first end of a therapeutic wand. The system also includes a head arranged opposite the tip at a second end of the therapeutic wand. The system includes a body arranged between the tip and the head, the body housing a control system for controlling operation of the therapeutic wand. The control system includes a printed circuit board, a timer electrically connected to the printed circuit board, the timer being programmable to determine an elapsed time of use of the therapeutic wand, and an indicator. The system also includes a grip arranged between the body and the head, the grip having an outer surface that is softer than the body to provide an ergonomic and comfortable location to hold the therapeutic wand.

The invention pertains to advances in real-time methods in nuclear magnetic resonance by offering a new dual-frequency dynamic nuclear polarization (DNP) method that uses a microwave beam to polarize the spins of electrons and concomitantly act as a NMR transmitter.

An electromagnetic stimulator and iontophoresis device used in treating retina and optical nerve diseases is provided. The electromagnetic stimulator and iontophoresis device enables to reach required threshold values for treating the retina and optical nerve diseases with magnetic fields to eliminate a thermal damage risk formed at a cellular level by cooling cages closed over electromagnetic coils, and allows usage by a patient alone at home, who has low vision, without receiving any professional help by an audio command guidance system including a speaker.

A system for therapeutic treatments with electromagnetic waves is described. The system comprises an antenna and an apparatus configured to generate a supply current for the antenna in order to generate the electromagnetic waves. The apparatus comprises a digital processing circuit configured to generate a first PWM signal, a switching stage configured to generate an amplified PWM signal, an analog low-pass or band-pass filter configured to generate the supply current by filtering the amplified PWM signal, and a current sensor configured to provide a digital sample indicative of the amplitude of the supply current.

Specifically, the digital processing circuit generates a sequence of first digital values of a periodic base pulse. Moreover, the digital processing circuit generates a second PWM signal having a packet switch-on period and a packet switch-off period, generates a third PWM signal having a train switch-on period and a train switch-off period, and generates an enable signal as a function of the second PWM signal and the third PWM signal. The digital processing circuit generates then a second digital value, wherein the second digital value is set to the first digital value when the enable signal has a first logic level and to zero when the enable signal has a second logic level.

In particular, the digital processing circuit generates the first PWM signal as a function of a third digital value indicative of the duty cycle of the first PWM signal, and varies the third digital value via a discrete proportional-integral regulation configured to regulate the difference between the second digital value and the digital sample to zero.

A system for cosmetically treating a patient's skin or body with one or more EMS coils and/or RF electrodes mounted on a planar holder; a hydrogel containing gel pad, the gel pad being positionable between the holder and the skin tissue; wherein the gel pad being of a material that is biocompatible and conducts RF and/or EMS energy when EMS energy is applied from the one or more EMS coils; a programmable controller to activate the one or more EMS coils; the programmable controller, after the planar holder is applied to the skin tissue, being configured to activate one or more of the plurality of EMS coils to provide treatment in the form of stimulation to the skin tissue.