A transcranial magnetic stimulation (TMS) treatment system is provided. The system includes a sensor device that senses EEG signals from a subject through one or more leads and a server device configured to receive EEG data corresponding to the subject. The server includes an analysis module configured to process the EEG data and determine a personalized resonant brain frequency and a minimum neuronal activation threshold of the subject based at least in part on EEG data corresponding to one or more leads of the sensor device. The analysis module is also configured to determine a TMS treatment protocol where the treatment protocol includes at least a frequency based on the personalized resonant brain frequency and an amplitude based on the minimum neuronal activation threshold. The system also includes a treatment device configured to deliver a TMS treatment to the subject based on the TMS treatment protocol received from the server.

The present disclosure describes methods and devices for increasing human life span (longevity) via electromagnetic treatment. An array of electromagnetic emitters are positioned proximal to a subject. An electromagnetic wave generator generates electromagnetic fields having a predetermined set of parameters. Life span is increased by applying the electromagnetic waves to the subject through the electromagnetic emitters.

The present disclosure relates to systems that comprise a millimeter size tetherless object powered by an external magnetic field, and an interactive hardware-software platform separate from the miniature device that generates, modulates and controls magnetic fields in a defined three-dimensional operational volume to propel, navigate the miniature device to a specific anatomical target to complete a (microsurgical) mission or task, as well as using such systems to perform microsurgery in the central nervous system (CNS).

A method for machine learning based artifact rejection is provided. The method may include applying a machine learning model to identify artefactual independent components in transcranial magnetic stimulation electroencephalogram data collected during a transcranial magnetic stimulation procedure. Clean transcranial magnetic stimulation electroencephalogram data is generated by removing, from the transcranial magnetic stimulation electroencephalogram data, the artefactual independent components. Real-time adjustments to parameters of the transcranial magnetic stimulation procedure may be performed based on the clean transcranial magnetic stimulation electroencephalogram data. Related systems and articles of manufacture, including computer program products, are also provided.

The improvement of administration of a therapeutic agent to a targeted region of a patient's brain is herein described. A magnetic material, preferably soluble iron, is administered to the patient. A magnetic field, for example via transcranial magnetic stimulation (TMS), is applied to the targeted region of the patient's brain. The magnetic field is used to agitate magnetic material localized to the targeted region of the brain, temporarily forming openings in the blood-brain barrier (BBB), increasing local perfusion, or both at the targeted region. A therapeutic agent is administered to the patient and is delivered to the targeted region of the patient's brain through openings in the BBB, local perfusion, or both.

Hyperscanning, the simultaneous measurement of brain activity among dyads or groups, has shown synchrony measured by fMRI, EEG, MEG, and fNIRS. This synchrony is evident during cooperative decision-making, but the underlying mechanism has not been elucidated. At minimum, in order for synchrony to occur, systems must oscillate and share information. Through the skin effect, changing magnetic fields permeate the human central nervous system, can share information from dyads and groups, and can synchronize oscillating oxygen reduction reactions (ORR) in the mitochondria. In vitro evidence has shown that ORR can be influenced μ-m tesla, extremely low frequency magnetic fields without producing thermal or ionization effects. Ascertaining the unique characteristics of such magnetic fields that can produce interbrain synchrony is a daunting task; however, this discovery could benefit impasse conflict negotiations.

Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

A method for treating conditions associated with thalamocortical dysrhythmia. The method includes applying transcranial low voltage electrical stimulation (TLVES) therapy or transcranial magnetic stimulation (TMS) therapy to a patient in need thereof, and administering to the patient a dissociative anesthetic during the TLVES therapy or the TMS therapy. A number of conditions including tinnitus, depression and pain can be treated with TLVES or TMS in combination with the dissociative anesthetic, such as an NMADR inhibitor, including ketamine.

A device is provided for the stimulation of neurons that includes a non-invasive stimulation unit to generate stimuli in multiple stimulation channels, where the stimulation unit stimulates a neuron population in the brain and/or spinal cord of a patient in different locations for each of the stimulation channels. Moreover, the device includes a control unit that controls the stimulation unit to generate repetitive bursts in each of the stimulation channels, where each of the bursts includes multiple stimuli and is designed so that they do not reset the phase of the neuronal activity of the respective stimulated neurons.

Systems, methods, and computer-readable media for enabling ultraviolet radiation treatments are provided.