A catheter device for use in the photodynamic treatment of a body cavity or hollow organ of the body, such as the bladder, the device being used in the photodynamic treatment of abnormalities, disorders or diseases of the internal surfaces of said body cavity or hollow organ.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

A light treatment system includes: a probe configured to be inserted into a body cavity, the probe including an optical fiber configured to propagate light, and a light emitter that is provided at a distal end of the optical fiber, the emitter being configured to emit the light; a balloon catheter into which the probe is inserted, the balloon catheter including a distal end portion that is to be inserted into the body cavity and that is to be dilated by being supplied with a liquid including air bubbles; and an air bubble generator configured to generate the air bubbles to be included in the liquid and change a property of the air bubbles.

Apparatus for the treatment of a target tissue with a laser beam in which the target tissue is immersed in a liquid medium within a body lumen. The laser device is configured to provide one or more laser pulses which are configured by a controller to have an energy sufficient to form one or more vapor bubbles in the liquid medium at the distal delivery end of the fiber. The one or more pulses are configured by the controller to: first, cause a vapor bubble to be formed distally of the distal end portion of the endoscope and around the distal delivery end of the optical fiber; second, cause a second bubble to be formed distally of the first bubble; and, third, inflate the second bubble as the first bubble has begun to collapse to expand an amount sufficient to displace a substantial portion of the liquid medium from the space between the distal delivery end of the fiber and the target tissue.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

This disclosure relates generally to medical devices, systems, and methods for activation of a photoactive agent during a medical procedure. In an aspect, a catheter system for activation of a photoactive agent may comprise a catheter comprising an elongate shaft comprising a proximal portion, a distal portion, and a first lumen extending along the elongate shaft. A first flexible circuit may be disposed about the distal portion of the elongate shaft. A plurality of first light-emitting diodes (LEDs) may be disposed along the first flexible circuit. A second flexible circuit may be disposed about the distal portion of the elongate shaft. A plurality of second LEDs may be disposed along the second flexible circuit. A control unit may be coupled to the proximal end of the elongate shaft. The communications cable may be disposed within the catheter and may electrically couple the first LEDs with the control unit.

A hand-held light treatment device configured with interchangeable emitter heads that are pre-programmed with desired treatment protocols and updated from a remote store of treatment protocols. The removable emitter heads each contain one or more treatment LEDs, a tracking light, a task light, a proximity sensor, and a control module. A tip is attached to the emitter head, either removably or integral therewith. In in one embodiment, the tip is integral with the emitter head and emits light perpendicular to the handle. Some embodiments have tips of various shapes that attach to the emitter heads, which permits a single device to direct the emitted energy at nearly any direction. The tips can be disposable or reusable. The light-emitting device may be used in conjunction with distilled water to treat infections, sterilize wounds or to minimize infection prior to surgical closure.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

A light treatment system includes: a probe configured to be inserted into a bladder, the probe including an optical fiber configured to propagate light, and a light emitter that is provided at a distal end of the optical fiber, the light emitter being configured to emit the light; and a balloon catheter into which the probe is inserted, the balloon catheter being configured to be inserted into the bladder, the balloon catheter including a distal end portion that is to be dilated in the bladder, a wall configured to divide inside of the distal end portion into two regions, and a reflector configured to reflect the light emitted by the light emitter, the reflector being provided on a surface of the wall, the surface facing a region of the two regions, the region being where the light emitter is positioned.

An antimicrobial urinary catheter device comprising a circumferential array of safe, antimicrobial lights around a urinary catheter directed for disinfecting the distal urethra, urethral meatus, and adjacent indwelling urinary catheter.