Systems, methods, and computer-readable media for enabling ultraviolet radiation treatments are provided.

The present invention relates to light therapy devices and related methods to treat the female genitalia and areas proximal thereto, including the vaginal cavity and vulvar regions in cisgender females or transgender females who have undergone sex reassignment, in particular for post-surgical indications, vaginal rejuvenation, or other medical conditions suitable for treatment with light therapy. The devices and methods are configured to provide a therapeutic amount of low level light therapy to a patient in need of treatment thereof.

An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivering of multiple energies to enhance a visual appearance.

A treatment apparatus and a treatment method capable of effectively treating cancer including a cervix. The treatment apparatus includes: a main shaft including a distal portion and a proximal portion; an inflation portion disposed on a distal side of the main shaft and configured to be inflated by inflowing a fluid; a distal shaft protruding from the inflation portion toward the distal side; and at least one irradiation unit configured to emit excitation light of an antibody-photosensitive substance from the distal shaft and the inflation portion.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

Provided are a treatment apparatus and a treatment method capable of effectively treating cancer tumor cell (for example cancer in a range including at least a part of a cervix). A treatment apparatus is configured to irradiate an antibody-photosensitive substance bound to a tumor cell with excitation light, and includes: a main shaft including a distal portion and a proximal portion; a distal structure portion disposed on a distal side of the main shaft and formed to be larger than the main shaft in a radial direction of the main shaft; a distal shaft protruding from the distal structure portion toward the distal side; and at least one irradiation unit configured to emit the excitation light of the antibody-photosensitive substance from the distal shaft and the distal structure portion.

A treatment apparatus and a treatment method capable of effectively treating cancer in a range including at least a part of a cervix. A treatment apparatus is configured to irradiate an antibody-photosensitive substance accumulated in a tumor cell with excitation light, and includes: a tubular device including an elongated tubular member; and an irradiation device configured to be inserted into the tubular member. The irradiation device includes a main shaft including a distal portion and a proximal portion, a disk portion disposed on a distal side of the main shaft, a distal shaft protruding from the disk portion toward the distal side, and an irradiation unit disposed on the distal shaft and configured to emit the excitation light.

Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.

Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.

An in vivo optical biopsy applicator of the vaginal wall for treatment planning, monitoring, and imaging guided therapy is described herein. The applicator may include an imaging probe operatively coupled to a laser ablation device. The applicator allows for non-invasive optical tissue monitoring in order to define pre- and post menopausal parameters, pre- and post-treatment microscopic changes, and offers an objective scientific tool in order to compare currently available medical, non-medicated, and energy-based treatment protocols.