A device for providing hyperthermia treatment includes an ultrasound energy generator configured to apply low intensity ultrasound to target tissue. The low intensity ultrasound energy induces therapeutic heating in the tissue at or below the surface of the skin. In order to control the temperature of the tissue during therapy, a microwave radiometer, such as a Dicke radiometer, can be used to measure the temperature of the tissue and feed back the temperature measurement to the ultrasound energy generator to control ultrasonic energy produced and control the temperature of the target tissue.

Embodiments of the present disclosure include a method for treating a condition of a subject. An implant defining a longitudinal axis is implanted between a nerve and skin of the subject. The implant includes an insulating member disposed, along the longitudinal axis, on at least a skin-facing side of the implant. Exactly two electrodes are disposed, along the longitudinal axis, at respective portions of a nerve-facing side of the implant. While the electrodes are driven to apply a treatment that stimulates the nerve, the insulating member is used to inhibit direct stimulation of sensory nerve fibers of the skin that are adjacent to the skin-facing side of the implant. Other embodiments are also described.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

A method for sterilizing viruses comprises generating a beam having radiating energy therein at a predetermined frequency for generating mechanical eigen-vibrations in a spherical virus to destroy the spherical virus and a predetermined cartesian beam intensity for imparting transverse shear forces to an icosahedral lattice structure of the spherical virus to destroy the icosahedral lattice structure of the spherical virus using beam generation circuitry. A resonance frequency of the spherical virus for inducing the mechanical eigen-vibrations in the spherical virus is determined based upon a size, geometry, and protein material of the spherical virus using a predetermined three-dimensional acoustical model of mechanical vibrations within the spherical virus. The beam generation at the predetermined frequency and the predetermined cartesian beam intensity is controlled using a controller responsive to the determined resonance frequency. The predetermined frequency equals the resonance frequency of the spherical virus. The beam on is radiated a predetermined area to destroy the spherical virus at the predetermined area using radiating circuitry. The mechanical eigen-vibrations at the resonance frequency of the spherical virus determined by the predetermined three-dimensional acoustical model are induced within the spherical virus to destroy the spherical virus responsive to the predetermined frequency. The transverse shear forces are imparted to the icosahedral lattice structure of the spherical virus to destroy the icosahedral lattice structure of the spherical virus.

A hemodynamic parameter (Hdp) monitoring system for diagnosing a health condition of a patient and for establishing Hdp marker values or Hdp surrogate marker values for purposes of comparison with Hdp values of a patient is provided. An Hdp monitor senses, measures, and records Hdp values exhibited by the patient during a basal or non-exposure period and furthermore Hdp values exhibited by the patient during or after an exposure period during which the patient is exposed to low-energy electromagnetic output signals. An electrically-powered generator is adapted to be actuated to generate said low-energy electromagnetic carrier output signals for exposing or applying to the patient such output signals during said exposure period.

A device for therapeutic neuromodulation in a nasal region can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

A hemodynamic parameter (Hdp) monitoring system for diagnosing a health condition of a patient and for establishing Hdp marker values or Hdp surrogate marker values for purposes of comparison with Hdp values of a patient is provided. An Hdp monitor senses, measures, and records Hdp values exhibited by the patient during a basal or non-exposure period and furthermore Hdp values exhibited by the patient during or after an exposure period during which the patient is exposed to low-energy electromagnetic output signals. An electrically-powered generator is adapted to be actuated to generate said low-energy electromagnetic carrier output signals for exposing or applying to the patient such output signals during said exposure period.

Methods and apparatus for the treatment, management and/or control of pain, in particular pain associated with, or caused or contributed to by, certain dermatological conditions.

A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.