Filter media having a relatively small pore size and related components, systems, and methods associated therewith are provided. The filter media may include a fibrous efficiency layer, a fibrous support layer, and a third layer adjacent to the efficiency layer. The efficiency layer may impart a relatively homogeneous pore structure to the filter media without adding substantial bulk to the filter media. The support layer may promote the homogeneity of the pore structure. For example, the support layer may prevent and/or minimize defects in the relatively thin efficiency layer that may result from manufacturing and/or processing. The third layer may serve to impart beneficial filtration (e.g., efficiency, dust holding capacity) and/or non-filtration (e.g., layer protection) properties to the filter media without adversely affecting one or more properties of the filter media. Filter media, as described herein, may be particularly well-suited for applications that involve liquid filtration, amongst other applications.

Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

A crystalline pigment or colorant composition having high color intensity and/or low sugar content, and methods and processes of preparation. The composition may comprise purified fruit and/or vegetable color juices.

Compositions and methods are described in which a primary detergent or surfactant in an aqueous solution is removed by the addition of a secondary detergent or surfactant in concentrations that exceed the critical micellar concentration (CMC) of the secondary detergent or surfactant. These compositions and methods are particularly applicable to protein-containing solutions. Typical primary detergents/surfactants include polysorbate 20, polysorbate 80, and Triton X-100. Suitable secondary detergents or surfactants can be ionic, nonionic, or zwitterionic. Typical secondary detergents/surfactants include, but are not limited to, galactoside detergents (e.g. octyl-β-galactoside), glucamide detergents (e.g. MEGA 8, MEGA 9, MEGA 10), cholamide detergents (e.g. CHAPS, CHAPSO, BIGCHAPS), and sulfobetaine detergents (such as sulfobetaine 3-10).

The present disclosure relates to hydrophilic microporous membranes comprising a modified surface. In addition, the present disclosure relates to a process for producing such hydrophilic membranes by modification of microporous membranes with fluorinated organosilane compounds and electron beam irradiation.

The present disclosure provides an exosome composition comprising a population of enriched exosomes. The exosome composition is directly obtained by isolation and ultrafiltration rather than by formulation. The present disclosure also provides a method for producing the exosome composition.

A membrane separation pretreatment apparatus including a membrane separation unit and a first underwater plasma discharge unit disposed in front of the membrane separation unit is provided. The membrane separation pretreatment apparatus includes a membrane separation unit configured to remove particulate matter contained in raw water, and a first underwater plasma discharge unit disposed in front of the membrane separation unit and configured to cause a portion of the raw water to be introduced into the membrane separation unit to perform underwater plasma discharging.

An apparatus for extracorporeal treatment of blood (1) has a supply line (2), a waste line (13) and an ultrafilter (19; 70) inserted in the supply line (2). An air inlet line is connected to the first chamber (21; 72) of the ultrafilter (19; 70) and a pressure sensor (41) configured for detecting pressure in the waste line (13). A controller (50) is configured to carry out, with the hydraulic circuit (100) in by-pass configuration, an integrity test procedure for detecting if the ultrafilter membrane has multiple or single fiber breaks. A method of testing the ultrafilter (19; 70) is also disclosed.

A silica membrane filter 10 includes an ultrafiltration membrane 15, which is disposed on a support body 14 and which contains an element 14 as a primary component, and a silica membrane 18 which is disposed on the ultrafiltration membrane 15 and which has an aryl group. The ultrafiltration membrane 15 has a structure infiltrated by Si of the silica membrane 18, the atomic ratio A (=Si/M) of Si to the element M in a membrane-side region 16, which is a region corresponding to 25% of the ultrafiltration membrane 15 from the silica membrane 18, satisfies 0.01≦A≦0.5, and the ratio A/B of the atomic ratio A to the atomic ratio B (=Si/M) in a base-material-side region 17, which is a region corresponding to 25% from the support body 14, is within the range of 1.1 or more.

The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.