An apparatus for extracorporeal treatment of blood (1) has a supply line (2), a waste line (13) and an ultrafilter (19; 70) inserted in the supply line (2). An air inlet line is connected to the first chamber (21; 72) of the ultrafilter (19; 70) and a pressure sensor (41) configured for detecting pressure in the waste line (13). A controller (50) is configured to carry out, with the hydraulic circuit (100) in by-pass configuration, an integrity test procedure for detecting if the ultrafilter membrane has multiple or single fiber breaks. A method of testing the ultrafilter (19; 70) is also disclosed.

Methods and systems for determining the integrity of a filter device are provided.

An integrity testing method for a porous medium in a housing having an interior separated by the medium into upstream and downstream portions, an inlet and an outlet communicating, respectively, with the upstream and downstream portions, the outlet connected to a closeable conduit, comprises filling the downstream portion and conduit with liquid, draining the upstream portion and filling it with gas while retaining liquid in the downstream portion, connecting a gas-filled testing volume to the downstream portion, maintaining gas pressure of a predetermined testing differential pressure in the upstream portion, the differential pressure being lower than a predefined bubble point of the medium, determining the pressure in the testing volume, the testing volume selected such that, when a medium is tested having a bubble point corresponding to the predefined bubble point, a pressure increase within the testing volume of about 100 mbar or more is obtained within 10 minutes.

Embodiments of a fluid filtration system constructed in accordance with principles of the present disclosure can be used to automatically condition the single use filter for efficient use thereof. For example, in embodiments, the fluid filtration system can include a filter conditioning program containing at least one of a filter priming module, a filter flushing module, and a filter pressurizing module.

A fluid filtration system includes a single use filter removably mounted to a cabinet of a workstation. The upstream end of the single use filter is in fluid communication with a pump via a fluid supply conduit that includes a test junction. An integrity test device is supported by the cabinet and is in fluid communication with the upstream end of the single use filter via a test conduit fluidly connected to the single use filter via the test junction of the fluid supply conduit. The integrity test device adapted to be connected to a source of pressurized gas and to selectively direct a flow of pressurized gas through the test conduit and the single use filter to perform a test operation on the single use filter.

Embodiments of a fluid filtration system constructed in accordance with principles of the present disclosure can be used to automatically condition the single use filter for efficient use thereof. For example, in embodiments, the fluid filtration system can include a filter conditioning program containing at least one of a filter priming module, a filter flushing module, and a filter pressurizing module.

A method is presented for checking the integrity of a hollow-fibre fluid filter, in particular a hollow-fibre dialyzer (1), which is constructed from a plurality of hollow fibres (15) enclosed by a membrane, with the steps of: perfusing the inside or outside of the hollow fibres (15) with a fluid, supplying the outside or inside of the hollow fibres (15) with a gas, wherein the gas has a higher pressure than the fluid, and determining a quantity of the gas which penetrates into the fluid through holes in the membrane. The method is characterized in that, after flowing through the hollow-fibre fluid filter (1), the fluid is channelled through a bubble trap (30), and in that a volume of gas (41) collecting in the bubble trap (30) during a predefined or predefinable reference period is determined. Furthermore, equipment for checking the integrity of a hollow-fibre fluid filter (1) is presented.

[PROBLEM] To provide an evaluation method and evaluation device with which the practical performance of a forward osmosis membrane can more accurately be measured.

[SOLVING MEANS] Provided is a method for evaluating a forward osmosis membrane module. The method includes the steps of, in a forward osmosis membrane module having spaces which are partitioned by a forward osmosis membrane including a porous support body and a separation function layer stacked thereon, connecting a feed solution line to a space on the separation function layer side, and connecting a draw solution line to a space on the porous support body side, and moving a solvent in the feed solution into the draw solution via the forward osmosis membrane while adjusting a physical pressure differential across the forward osmosis membrane to a constant value within the range of more than 0 kPa to 200 kPa.

A filter screening tool, system, and method allowing high throughput screening of filters (such as hollow fiber filters), such as for use in bioprocessing workflows. Feed material may be fed through different filter modules to assess, measure, analyze, determine, evaluate, teste, compare, screen, etc., properties or characteristics, etc., of filters within the filter modules. Each filter module may house a different type (e.g., material or configuration) of filter so that different filters may be compared and screened, such as for a selected use.

A method for making a graphene membrane includes applying a suspension of graphene platelets in a fluid onto a porous substrate, and applying a pressure differential to force the fluid through the substrate to yield a filtered fluid while retaining the graphene platelets on the substrate. The graphene platelets and the substrate form the graphene membrane.