Membrane oxygenators useful in a variety of medical situations, including various short-term procedures and relatively longer-term life support, and components of membrane-based oxygenators, such as conditioning modules for exchanging oxygen for carbon dioxide during extracorporeal conditioning of blood, are described. A conditioning module includes a plurality of mats of hollow fibers and a potting material disposed throughout the peripheral edges of the mats to create a circumferential seal that defines a passageway through the plurality of fiber mats having a substantially circular cross-sectional shape. The circumferential seal defines an effective fiber length for each of the hollow fibers. A resisting member is disposed across the proximal ends of at least some of the hollow fibers and is adapted to resist fluid flow into each of the hollow fibers based on the effective fiber length of the particular hollow fiber.

A fluid separation apparatus comprising a fluid separation membrane is provided. The fluid separation apparatus comprises a fluid separation membrane extending in one direction and having a cross-section with a closed curve shape, wherein the fluid separation membrane has a thickness of 0.1 mm to 2 mm, and an outer diameter of 60 mm to 360 mm when the cross-section is adjusted to be circular.

A hollow fibre membrane having a coiled, a hemihelix, a helical or an undulated native form, in which the membrane can be stretched by up to 4-times its original length with no plastic deformation, and wherein the native form of the membrane is produced by the asymmetric flow of liquid polymer through an opening of a die or nozzle.

An embodiment an apparatus, including: a housing that permits airflow there-through; an air permeable filter disposed in the housing; where the air permeable filter is angled such that it does not sit in a horizontal plane across the housing; and an attachment mechanism for securing the housing to an enclosure that houses heat generating electronics. Other embodiments are described and claimed.

Systems and methods can be used to produce fibers with external corrugations, internal corrugations, or both. These fibers can be used, for example, in hollow fiber membrane modules.

Methods of producing a deformed porous hollow fiber membrane by thermally induced phase separation, particularly by discharging a fusion kneaded product containing a thermoplastic resin and an organic liquid through an orifice of a hollow fiber-forming deformed nozzle; cooling and solidifying the fusion kneaded product discharged through the deformed nozzle to form the product into a hollow fiber-like material having a deformed cross section at a cross section vertical to a discharging direction; and extracting away the organic liquid from the hollow fiber-like material to obtain the deformed porous hollow fiber membrane, wherein an inorganic fine powder is kneaded in the fusion kneaded product.

A method of manufacturing a separator element for obtaining molecular and/or particulate separation by tangential flow of a fluid medium for treatment into a filtrate and a retentate, the element having a structure (2) of at least two porous rigid columns (3) made of the same material, positioned side by side to define, outside their outside walls, a volume (4) for recovering the filtrate, each column (3) presenting, internally, at least one open structure (5) for passing a flow of the fluid medium, opening out in one of the ends of the porous column for inlet of the fluid medium for treatment, and in the other end for outlet of the retentate. The element is a single-piece rigid structure (2) made as a single piece that is uniform and continuous throughout, without any bonds or exogenous additions.

The present invention provides a carbon membrane for fluid separation with which a high-pressure fluid can be separated and purified and which has excellent pressure resistance and is less apt to be damaged. The present invention relates to a carbon membrane for fluid separation, including: a core layer which has a co-continuous porous structure; and a skin layer which has substantially no co-continuous porous structure and is formed around the core layer.

The invention resides in an apparatus for treatment of a substance. The apparatus has a substance tube for enabling a substance to be treated to pass in to the substance tube via the substance-inlet and out of the substance tube through the substance-outlet. The apparatus also has a cleaning chamber, wherein the substance tube is configured in fluid communication with the cleaning chamber to enable a substance to diffuse the permeable membrane between the substance tube and the cleaning chamber such that a substance can be substantially cleaned by a cleaner, the substance comprising blood or plasma and the cleaner comprising a cell culture. The substance tube is removably connectable with the cleaning chamber for inter-changeability or serviceability. The apparatus can further comprise a support compartment configured to connect to, or enclosing, the cleaning chamber, which functions to carry a fluid to substantially maintain the functionality of the cleaner.

The present invention is related to a method for fabricating multilayer singlebore membranes (10) or multilayer multibore membranes (20) for ultrafiltration applications including the following method steps: (a) feeding at least a material of a substrate (12), at least one material of a functional layer (14, 15) and a bore fluid (36) to a spinneret (30) simultaneously; (b) forming said membranes (10, 20) as a tube-like string (54) in a one-step process in said spinneret (30); (c) thereby assigning a functionality to said functional layer (14, 15) applied on at least one surface (13, 17) of said substrate (12). The invention is also related to a spinneret (30) for fabricating multilayer singlebore membranes (10) or multilayer multibore membranes (20), using the inventive method, and to a system comprising such a spinneret (30).