Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

A mixing apparatus for mixing or stirring substances includes a mixing tank for receiving the substances, a rotor arranged in the mixing tank with which a vane for mixing or stirring the substances can be driven to rotate about an axial direction, and a stator arranged outside the mixing tank and with which the rotor can be driven contactlessly magnetically to rotate about the axial direction in the operating state and is supported magnetically with respect to the stator. A bar extends in the axial direction and is rotationally fixed to the rotor, and a limiting element fixed with respect to the mixing tank cooperates with the bar, with the limiting element being configured such that the bar rotates with respect to the limiting element and with a tilt of the rotor being limited by a physical contact between the bar and the limiting element.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

An apparatus for mixing a particulate material with a liquid in a container is adapted for tumble blending. The apparatus comprises a mixing device and a liquid injection nozzle. The mixing device includes mixer elements adapted to mix a particulate material by mechanical action. The nozzle is disposed to direct liquid in the direction of the mixer elements when mixing is taking place and ingress of material is prevented from entering into the nozzle.

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

A powder rotary fluidization device and a method thereof are provided. The powder rotary fluidization device includes a support device, the support device is provided with an installing plate, the installing plate is provided with a power device and a fluidization device, and the power device is in transmission connection with the fluidization device. After a position of the fluidization device on the installing plate is adjusted through the support device, the power device is started to drive the fluidization device to rotate, and meanwhile gases are introduced into the fluidization device to process powder. and therefore the problem of poor processing effect on fine powder with high viscosity is solved through the rotatable fluidization device.

An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material. The method of use also includes connection of a transfer set to a housing in a manner that further ensures optimum efficiency and safety.

Embodiments of the present application relate to compositions bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process with large particle diameter span.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.