A device for loading an in particular higher-viscosity liquid, such as a silicon resin, for example, with air or another gas. The device has a pressure vessel receiving the liquid and the gas, in which pressure vessel an agitator, having a drive shaft set through the pressure vessel at least in part, is arranged. In order to enable the particularly fast and homogeneous intermixing of the liquid and gas, the drive shaft is arranged in a conveying pipe and drives a conveying organ, in particular a screw conveyor, which transports the liquid through the conveying pipe to at least one outlet, and there is an running-off surface underneath the outlet from the conveying pipe for the liquid flowing out of the outlet. Upon actuation of the agitator, the liquid is thus not only well intermixed together with the air already received therein, but at the same time conveyed through the conveying pipe to the running-off surface, on which it can discharge in a thin layer and has a particularly large exchange area with the gas as a result.

A sparger assembly for a bioprocessing system includes a first layer having a plurality of pores of a first size, and a second layer disposed above the first layer and having a plurality of holes of a second size, the second size being greater than the first size. The pores of the first layer and the holes of the second layer allow for the passage of a sparge gas through the first layer and the second layer.

A sparger assembly (700) for a bioprocessing system includes a base plate (710) and at least one aeration manifold (712, 714) removably connected to tire base plate. Each aeration manifold includes at least one inlet for receiving a gas and a plurality of gas outlet openings for delivering tire gas to a fluid within the bioprocessing system. An impeller assembly (740) fora bioprocessing system includes a hub and at least one blade (742) operatively connected to the hub. The at least one blade includes a first portion connected to the hub and extending generally vertically, and a second portion extending at an upward angle from tire first portion.

A sparge for use in a high-pressure vessel operated at elevated temperatures and having high energy agitators for suspending mineral containing particles in a slurry. The sparge injects reagent fluids into the slurry to reduce reaction times and for controlling process parameters for extracting valuable minerals from the particles. The sparge has a vapor lock to inhibit the flow of particulate material and detritus material under low or no fluid flow situations which occur commonly in the operation of high pressure autoclaves. The sparge has a fluid flow path that increases in cross-sectional area in the direction of flow of reagent fluids so as to keep reagent fluids flowing at a velocity below a critical impingement velocity that can cause metal materials of the sparge to either wear rapidly, combust and in the worst case lead to loss of containment and violent and rapid depressurization of the high pressure vessel.

A bioproduction mixing system includes a flexible compartment having a first end, a second end, and a sidewall extending therebetween, a center axis passing through the flexible compartment between the first end and the second end. A helical assembly is disposed within the flexible compartment and is suspended between the first end and the second end, the helical assembly being offset from the center axis of the flexible compartment.

An apparatus for treating fluids such as waste streams with improved aeration efficiency and dual function operation has a blower-assisted aerator, an impeller, a baffle structure circumscribing an air line that includes a first baffle and a second perforated baffle downstream from the first baffle, and a liquid reservoir containing a liquid. The impeller is fully submerged, and located upstream of the fully submerged baffle structure. A fully submerged air outlet is located downstream of the baffle structure, preferably in close proximity to the perforated baffle. When the blower is stopped and the impeller rotating, the baffle structure prevents aspiration into the liquid. In some embodiments, the baffle structure is removably affixed to an air outlet from the blower-assisted aerator, and so may be applied to pre-existing blower-assisted aerators. In some embodiments, one or both of the first and second baffles may resemble flat, domed, cupped, or hemispherical washers.

A method of installing a flexible bioprocess container in a bioprocessing system having a rigid housing with an interior compartment and extending between a top and an opposing base. The method includes coupling a first surface of the flexible bioprocess container to a moveable platform positioned within the interior compartment of the rigid housing; coupling a second surface of the flexible bioprocess container to the base of the rigid housing; and moving the movable platform relative to the rigid housing and toward the top of the rigid housing so as to at least partially expand the flexible bioprocess container within the interior compartment of the rigid housing.

The present set of embodiments relate to a bioproduction system, method, and apparatus for mixing a fluid. The bioproduction mixing system includes an offset helical assembly having a stabilizer and impeller for mixing a fluid within a flexible compartment The bioproduction mixing system is designed for efficient mixing of the fluid and for use with a variety of different impellers that can be located at different locations according to the volume and shape characteristics of the flexible compartment. The bioproduction mixing system is optimized to eliminate stagnation zones while maximizing bulk fluid flow.

The present set of embodiments relate a system, method, and various devices for installation of a bioproduction system. The bioproduction system includes a rigid housing having a moveable platform to assist in the installation of a bioprocessing container within. The system also includes mounting systems for a variety of peripherals originating from the flexible container while safeguarding operators. More specifically, the system includes systems and methods for mounting bearings, organizing tube sets, and placement of the flexible container in its proper orientation.

A gas dispersion system may include a drive mechanism, a drive shaft having a proximal end operably coupled to the drive mechanism, extending to a distal end, and configured to transfer rotational motion and torque, a mixing element arranged at or near the distal end of the drive shaft including a hub and multiple blade pairs, each blade pair including an upper blade and a lower blade secured to the hub and cantilevering freely and generally radially away from the hub.