A reactor system includes a reactor vessel configured to contain a process fluid, and a sparger assembly that operably coupled to the reactor vessel and configured to supply a mixture of a gas and a recirculated process fluid to the reactor vessel. The sparger assembly includes a plurality of sparger chambers. Each sparger chamber includes a process fluid conduit fluidly coupled to a process fluid return of the reactor vessel via a process fluid inlet, wherein the process fluid inlet has a first block and bleed valve assembly. Each sparger chamber includes a sparger conduit fluidly coupled to the process fluid conduit and a sparger disposed within the sparger conduit and fluidly coupled to a gas source via a gas inlet. Each sparger chamber also includes a process fluid-gas mixture outlet that fluidly couples the sparger conduit to a sparger outlet of the reactor vessel.

Provided are a method for preparing liposomes comprising ultrasound reactive microbubbles for drug delivery, comprising (a) a step of producing ultrasound reactive microbubbles comprising an inert gas therein and having a first shell formed on the outer surface thereof, followed by forming a uniform size distribution of the ultrasound reactive microbubbles through an extruder; and (b) a step of producing liposomes comprising the ultrasound reactive microbubbles distributed in a uniform size and a medicament therein and having a second shell formed on the outer surface thereof, followed by forming a uniform size distribution of the liposomes through an extruder; and a liposome using same.

Presented and described herein is a stroke system (1) for dosing a fluid from a container (3), comprising a piston pump (5) with a piston (7), so that a fluid can be dosed from a container (3) by displacement of the piston (7), and a temperature control device (29) for controlling the temperature of the fluid to be dosed by means of the stroke system (1).

Provided herein is a method for preparing microcarrier particles, comprising the steps of allowing the dispersed phase liquid flow through a multi-hole plate at a low temperature to form liquid microspheres in a continuous phase, and enabling a synthetic polymer and/or natural biological macromolecules within the liquid microspheres to be subject to a curing reaction at a low temperature to form particles. Further provided herein are the method for preparing an emulsion and an apparatus and process system for preparing microcarrier particles, which can be used for preparing emulsions and microcarrier particles on a large scale.

A manufacturing apparatus for a solidified matter of an ultra-fine bubble (UFB)-containing liquid includes: a UFB generating unit that generates the UFB-containing liquid; and a cooling unit that generates the solidified matter of the UFB-containing liquid by cooling the UFB-containing liquid. The cooling unit cools the ultra-fine bubble-containing liquid such that a first solidified portion and a second solidified portion at a lower ultra-fine bubble concentration than that of the first solidified portion are formed in the solidified matter.

The present invention relates to a process of producing a nano Omega-3 microemulsion system includes: (i) preparing a dispersal phase by heating Omega-3; (ii) preparing a carrier by heating a liquid PEG (polyethylene glycol); (iii) adding the carrier to the dispersal phase; (iv) emulsifying as follows: when the temperature arrives at 60° C., adding ACRYSOL K-140 to the mixture of the carrier and dispersal phase in step (iii), continuing to stir at a speed of 500 to 700 rpm, at a temperature of 60 to 80° C., in vacuum, for 3 to 5 hours, controlling the quality of resulting product by dissolving into water and measuring the transparency, the reaction is quenched, the temperature is decreased slowly until it is in the range of 40 to 60° C.; emulsifying for the entire mixture for 30 minutes; (v) filtrating the product by injecting through nanofilter system before filling-packaging.

Provided is an ultra-fine bubble-containing liquid manufacturing apparatus that can suppress viable cell contamination inside a UFB generating unit. To this end, it is provided with an ultra-fine bubble generating unit that generates an ultra-fine bubble by making film boiling by a heating unit in a liquid in which a gas is dissolved, and a radiating unit that is capable of irradiating a wetted portion of the ultra-fine bubble generating unit with ultraviolet rays.

Provided is an UFB generating apparatus and an UFB generating method capable of efficiently generating an UFB-containing liquid with high purity. The ultrafine bubble generating apparatus includes a generating unit that generates ultrafine bubbles in a liquid and a post-processing unit that performs predetermined post-processing on the ultrafine bubble-containing liquid generated by the generating unit. The generating unit generates the ultrafine bubbles by causing a heating element, which is provided in the liquid on which the pre-processing is performed, to generate heat to generate film boiling on an interface between the liquid and the heating element.

Embodiments of the present application relate to compositions bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process with large particle diameter span.

A molten salt reactor includes a reactor vessel and a molten salt contained within the reactor vessel and undergoing a nuclear reaction. The molten salt includes insoluble metal fission products and dissolved gas fission products produced by the nuclear reaction. There is a separation unit configured to receive the molten salt and remove the insoluble metal fission products and dissolved gas fission products from the molten salt. The separation unit includes a laundering chamber into which the molten salt is introduced to form a froth containing the insoluble metal fission products and dissolved gas fission products. There is a filtration chamber, interconnected to the laundering chamber, configured to receive the froth from the laundering chamber and separate from the froth the insoluble metal fission products and dissolved gas fission products.