A device (30) includes a base connector (32) having an opening (33) and an impeller connector (64) coupled to the base connector (32). The impeller connector (64) has a through-passage (66) aligned with the opening (33) of the base connector (32). Further, the device (30) includes a flexible tube (34) having a first end (36) and a second end (40), where the first end (36) of the flexible tube (34) is coupled to the impeller connector (64). Furthermore, the device (30) includes a seal component (38) and an impeller (42) coupled to the second end (40) of the flexible tube (34). Additionally, the device (34) includes an enclosure (46) disposed enclosing the impeller (42), the flexible tube (34), the impeller connector (64), and the base connector (32).

A device (30) includes a base connector (32) having an opening (33) and an impeller connector (64) coupled to the base connector (32). The impeller connector (64) has a through-passage (66) aligned with the opening (33) of the base connector (32). Further, the device (30) includes a flexible tube (34) having a first end (36) and a second end (40), where the first end (36) of the flexible tube (34) is coupled to the impeller connector (64). Furthermore, the device (30) includes a seal component (38) and an impeller (42) coupled to the second end (40) of the flexible tube (34). Additionally, the device (34) includes an enclosure (46) disposed enclosing the impeller (42), the flexible tube (34), the impeller connector (64), and the base connector (32).

The present disclosure provides advantageous rotary interfaces for fluid assemblies (e.g., rotary interfaces for fluid flow in bioreactor applications), and related methods of fabrication and use. More particularly, the present disclosure provides improved rotary interfaces for fluid flow through porous impellers for filtration and/or sparging for fluid assemblies (e.g., bioreactor applications), and related methods of fabrication and use. Disclosed herein is a fluid assembly (e.g., bioreactor) that includes a porous impeller which is in fluid communication with a hollow shaft that can be used to transport a reaction fluid to an external storage tank or the like. The fluid assembly/bioreactor can include a coupling mechanism that transmits rotary motion from a motor to a primary shaft and then to a hollow secondary shaft, while at the same time permitting removal of a filtrate from the fluid assembly or bioreactor via the hollow secondary shaft and a porous impeller.

The present disclosure provides advantageous rotary interfaces for fluid assemblies (e.g., rotary interfaces for fluid flow in bioreactor applications), and related methods of fabrication and use. More particularly, the present disclosure provides improved rotary interfaces for fluid flow through porous impellers for filtration and/or sparging for fluid assemblies (e.g., bioreactor applications), and related methods of fabrication and use. Disclosed herein is a fluid assembly (e.g., bioreactor) that includes a porous impeller which is in fluid communication with a hollow shaft that can be used to transport a reaction fluid to an external storage tank or the like. The fluid assembly/bioreactor can include a coupling mechanism that transmits rotary motion from a motor to a primary shaft and then to a hollow secondary shaft, while at the same time permitting removal of a filtrate from the fluid assembly or bioreactor via the hollow secondary shaft and a porous impeller.

A storage and mixing device for two-component polymethyl methacrylate bone cements having a cylindrical interior of a cartridge that is delimited on a front side by a cartridge head, a plunger arranged to be axially movable in the cylindrical interior of the cartridge and spaced from the cartridge head, a powdery first parent component of the bone cement, that is contained in the interior between the plunger and the cartridge head, a feed-through arranged in the cartridge head or in the cylinder barrel of the cartridge between the plunger and the cartridge head. The feed-through is connectable to a fluid line, a receptacle for a monomer liquid, wherein the fluid line connects the feed-through to the receptacle in a liquid-permeable manner, and a press-out device pushable into the receptacle, so that monomer liquid is pressable out of the receptacle into the fluid line. The plunger (2) is spaced from a back side of the cylindrical interior, located opposite the front side, so that, by moving the plunger in the direction of the back side, the press-out device is pushable into the receptacle and a reduced pressure is producible in the interior of the cartridge between the plunger and the cartridge head.

A storage and mixing device for PMMA bone cements having a cylindrical interior of the cartridge that is delimited on a front side by a cartridge head with a closed delivery opening, a plunger which is arranged to be axially movable in the cylindrical interior of the cartridge and which is spaced from the cartridge head. The plunger circumferentially rests against the inner wall of the interior, so that the plunger divides the interior of the cartridge into two sections in a gas-tight manner, a powdery first parent component of the bone cement, which is contained in the interior between the plunger and the cartridge head, a feed-through which is arranged in the cartridge head or in the cylinder barrel of the cartridge between the plunger and the cartridge head, wherein the feed-through is connected to a fluid line in which a monomer liquid as a second parent component of the bone cement is contained or into which a monomer liquid is fillable or introducible. A filter is arrangeable in the cartridge head, in the feed-through and/or in the fluid line, wherein the filter is permeable to the monomer liquid and impermeable to the first parent component, wherein the plunger is spaced from a back side of the cylindrical interior, located opposite the front side, to an extent that, by moving the plunger in the direction of the back side, a reduced pressure is producible in the interior of the cartridge between the plunger and the cartridge head, wherein the reduced pressure is able to suck the monomer liquid out of the fluid line into the interior of the cartridge.

A rotary injector comprising an elongated shaft having a proximal end and a distal end, and an impeller at the distal end of the elongated shaft, the elongated shaft and the impeller being collectively rotatable during operation around an axis of the shaft, the rotary injector being hollow and having an internal supply conduit extending along the shaft and across the impeller, the supply conduit having an inlet at the proximal end of the shaft, a main portion extending from the inlet to a discharge portion, the discharge portion extending to an axial outlet, the discharge portion having a narrow end connecting the main portion of the supply conduit and a broader end at the axial outlet.

A mixing impeller (10) for mixing a sealant inside a cartridge (1) is disclosed. The mixing impeller (10) comprises a central hub (11) and at least two mixing arms (20) extending radially outward from the central hub (11). Each of the mixing arms (20) may include a leading edge (24), a trailing edge (26), and a wiping edge (28) extending circumferentially between a leading tip (25) of the leading edge (24) and a trailing edge transition (27) of the trailing edge (26). The wiping edge (28) may have an arc length defining a wiping edge (28) angle, the leading tip (25) may be circumferentially offset in a direction of rotation of the mixing impeller (10) defining a leading edge (24) angle to provide a forward swept configuration, and the wiping edge (28) angle may be greater than the leading edge (24) angle. A sealant cartridge (1) and mixing impeller (10) assembly is also disclosed.

A mixing impeller (10) for mixing a sealant inside a cartridge (1) is disclosed. The mixing impeller (10) comprises a central hub (11) and at least two mixing arms (20) extending radially outward from the central hub (11). Each of the mixing arms (20) may include a leading edge (24), a trailing edge (26), and a wiping edge (28) extending circumferentially between a leading tip (25) of the leading edge (24) and a trailing edge transition (27) of the trailing edge (26). The wiping edge (28) may have an arc length defining a wiping edge (28) angle, the leading tip (25) may be circumferentially offset in a direction of rotation of the mixing impeller (10) defining a leading edge (24) angle to provide a forward swept configuration, and the wiping edge (28) angle may be greater than the leading edge (24) angle. A sealant cartridge (1) and mixing impeller (10) assembly is also disclosed.

A device for the mixing fluid media. The device is a bladeless mixer. The device comprises a hollow body with at least a single inlet opening in its bottom and at least a single outflow region in its side. The device is rotated at a speed at which the media due to centrifugal forces enters the device's hollow cavity via the inflow opening or unit. The media is discharged from the cavity through one or more outlet units or openings in the sides or in the top of the device. During mixing the media does not rise above the level of the undisturbed media.