This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.

An agitating bar and an agitator including the same are provided. The agitating bar includes a barrier unit in addition to a rotating shaft, and an impeller unit. Therefore, the agitating bar can be useful in preventing the stream of a fluid which flows rapidly toward a fluid outlet port in a state in which the fluid is not mixed uniformly around the rotating shaft, thereby enhancing agitation efficiency and a degree of homogenization for the mixed fluid.

The invention relates to a stirred tank reactor for gas-liquid mass transfer in a slurry. The reactor includes a reactor tank (1) having a first volume (V.sub.1), a drive shaft (2) that extends vertically in the reactor tank, a motor (3) for rotating the drive shaft (2), a main impeller (4) which is a downward pumping axial flow impeller attached to the drive shaft (2) to create a main flow pattern in the reactor tank, and a gas inlet (5) arranged to supply gas into the reactor tank (1) to be dispersed to the liquid. The reactor includes a mechanical gas sparging apparatus (6) comprising a dispersion chamber (7) having a second volume (V.sub.2) which is substantially smaller than the first volume (V.sub.1) of the reactor tank (1), the dispersion chamber being arranged coaxial with the drive shaft (2), and the gas inlet (5) being arranged to feed gas into the dispersion chamber (7), and mixing means (8, 9, 10, 11, 12) arranged within the dispersion chamber (7) for mixing the gas into liquid by dispersing the gas to fine bubbles before the bubbles enter the main flow pattern. The mixing power per unit volume inside the dispersion chamber (7) is significantly larger than the mixing power elsewhere in the reactor.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.

An apparatus for agitation of fluids is described that comprises an agitation chamber, an impeller configured to have a motor, a shaft, and blades, and a plurality of baffles. Further, the plurality of baffles have a predetermined shape and configuration. Further, the plurality of baffles are placed on a side wall of the agitation chamber.

An apparatus for agitation of fluids is described that comprises an agitation chamber, an impeller configured to have a motor, a shaft, and blades, and a plurality of baffles. Further, the plurality of baffles have a predetermined shape and configuration. Further, the plurality of baffles are placed on a side wall of the agitation chamber.

The present disclosure provides a stirred tank. The stirred tank includes a tank body, a stirring shaft, a plurality of blades and baffles. The tank body is configured to hold the material to be stirred; an axis of the stirring shaft is configured to coincide with an axis of the tank body; the blades are disposed on the stirring shaft; the baffles are disposed in the tank body and arranged at a periphery of the stirring shaft, and each baffle is provided with a plurality of punched holes and has a wave-like cross section. During the agitation of the stirred tank, a large number of high-speed jets are formed after the fluid passes through the punched holes.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.

An aeration system including a frame and an aerator. The aerator may be supported by the frame. The aerator may include an input and an output. The aerator may be configured to rotate with respect to the frame, and upon rotating, receive a first fluid at the input and output the first fluid into a second fluid at the output.

A stirring device includes a tank, a first stirring mechanism, a second stirring mechanism, and a flow blocking mechanism located in the tank and arranged on a side wall of the tank. A first stirring shaft of the first stirring mechanism is located in a middle part of the tank, and one end of the first stirring shaft is provided with a radial-flow stirring paddle located in the tank. A second stirring shaft of the second stirring mechanism is located on one side of the first stirring shaft. The second stirring shaft and the first stirring shaft are arranged in a radial direction of the tank. One end of the second stirring shaft is provided with an axial-flow stirring paddle located in the tank. The flow blocking mechanism is configured to block movement of materials in the tank.