A multistage centrifugal atomizer comprises an outer shell that contains an inlet port and an outlet port and that encloses a tundish, a first inclined rotating surface and a second inclined rotating surface. The first inclined rotating surface is opposedly disposed to the second inclined rotating surface. The inlet is used to introduce a molten material into the multistage atomizer and the outlet is used to remove ultrafine particles having a D50 of less than 20 micrometers.

A multistage centrifugal atomizer comprises an outer shell that contains an inlet port and an outlet port and that encloses a tundish, a first inclined rotating surface and a second inclined rotating surface. The first inclined rotating surface is opposedly disposed to the second inclined rotating surface. The inlet is used to introduce a molten material into the multistage atomizer and the outlet is used to remove ultrafine particles having a D50 of less than 20 micrometers.

Described herein are apparatuses and methods for conditioning particles. In some embodiments, the apparatuses and methods are configured for first-in-first-out transit of particles through a chamber containing a conditioning fluid.

The present disclosure relates to a process and an apparatus for producing powder particles by atomization of a feed material in the form of an elongated member such as a wire, a rod or a filled tube. The feed material is introduced in a plasma torch. A forward portion of the feed material is moved from the plasma torch into an atomization nozzle of the plasma torch. A forward end of the feed material is surface melted by exposure to one or more plasma jets formed in the atomization nozzle. The one or more plasma jets being includes an annular plasma jet, a plurality of converging plasma jets, or a combination of an annular plasma jet with a plurality of converging plasma jets. Powder particles obtained using the process and apparatus are also described.

The present disclosure relates to a process and an apparatus for producing powder particles by atomization of a feed material in the form of an elongated member such as a wire, a rod or a filled tube. The feed material is introduced in a plasma torch. A forward portion of the feed material is moved from the plasma torch into an atomization nozzle of the plasma torch. A forward end of the feed material is surface melted by exposure to one or more plasma jets formed in the atomization nozzle. The one or more plasma jets being includes an annular plasma jet, a plurality of converging plasma jets, or a combination of an annular plasma jet with a plurality of converging plasma jets. Powder particles obtained using the process and apparatus are also described.

A process for making multiparticulates, comprising providing a molten feed comprising an active ingredient and an excipient, and providing a spinning disc sprayer comprising a rotating disc having a feed-receiving surface driven from above by a hollow drive shaft, wherein axes of rotation of the hollow drive shaft and rotatable disc are coaxial and a downward end of the hollow drive shaft is disposed with a distributor for regulating flow of the molten feed into the well, the distributor and the well together configured for providing a substantially radial, uniform outward flow of the molten feed across the feed-receiving surface.

A process for making multiparticulates, comprising providing a molten feed comprising an active ingredient and an excipient, and providing a spinning disc sprayer comprising a rotating disc having a feed-receiving surface driven from above by a hollow drive shaft, wherein axes of rotation of the hollow drive shaft and rotatable disc are coaxial and a downward end of the hollow drive shaft is disposed with a distributor for regulating flow of the molten feed into the well, the distributor and the well together configured for providing a substantially radial, uniform outward flow of the molten feed across the feed-receiving surface.

Spray drying method and systems are disclosed that include one or more single-use components. Single-use spray drying systems can include a drying chamber with an inner surface formed of a polymeric material. The single-use components can be pre-sterilized and sterile packaged to provide improved efficiencies and greater operational flexibility in spray drying systems.

An atomizing spray dryer employs one or more stages defined by ultrasonic transducers in close proximity to a liquid feed opening forming a path of an atomization flow for producing uniform droplets from a close tolerance with the transducer. The atomization flow exits a gap between the transducer and an outer edge of the opening, such that the passed liquid is responsive to an oscillation of the transducer for forming the droplets. A conical or other suitably shaped transducer engages a substantially round liquid feed opening. Subsequent stages may include a circular, ring, or other suitable shape aligned to receive the atomization flow from a circumference of the conical base, or may also take any suitable shape, preferably to receive droplets directed by the first stage.

An atomizing spray dryer employs one or more stages defined by ultrasonic transducers in close proximity to a liquid feed opening forming a path of an atomization flow for producing uniform droplets from a close tolerance with the transducer. The atomization flow exits a gap between the transducer and an outer edge of the opening, such that the passed liquid is responsive to an oscillation of the transducer for forming the droplets. A conical or other suitably shaped transducer engages a substantially round liquid feed opening. Subsequent stages may include a circular, ring, or other suitable shape aligned to receive the atomization flow from a circumference of the conical base, or may also take any suitable shape, preferably to receive droplets directed by the first stage.