The present invention comprises an apparatus and method for producing a microparticle and pharmaceutical compositions thereof. The apparatus and method rely on continuous inkjet (CIJ) printing to provide high quality microparticles at an improved rate.

A method for controlling a prilling bucket in the prilling of a a urea melt (UM) including: feeding the urea melt to a prilling bucket (1) which vibrates under the action of a magnetostrictive device (2), wherein the vibration of the bucket is controlled, as a function of the amount of urea melt to be prilled, by the following steps: acquisition of a time-varying input signal (3) which represents the flow rate of urea melt fed to the prilling bucket; generation of a first signal (5) and of a second signal (6), independently from each other, as a function of said input signal (3); generation of a third signal (10) having a frequency which is modulated by said first signal and an magnitude which is modulated by said second signal, and use of said third signal to drive said magnetostrictive device (2).

A method for controlling a prilling bucket in the prilling of a a urea melt (UM) including: feeding the urea melt to a prilling bucket (1) which vibrates under the action of a magnetostrictive device (2), wherein the vibration of the bucket is controlled, as a function of the amount of urea melt to be prilled, by the following steps: acquisition of a time-varying input signal (3) which represents the flow rate of urea melt fed to the prilling bucket; generation of a first signal (5) and of a second signal (6), independently from each other, as a function of said input signal (3); generation of a third signal (10) having a frequency which is modulated by said first signal and an magnitude which is modulated by said second signal, and use of said third signal to drive said magnetostrictive device (2).

A method for controlling a prilling bucket in the prilling of a a urea melt (UM) including: feeding the urea melt to a prilling bucket (1) which vibrates under the action of a magnetostrictive device (2), wherein the vibration of the bucket is controlled, as a function of the amount of urea melt to be prilled, by the following steps: acquisition of a time-varying input signal (3) which represents the flow rate of urea melt fed to the prilling bucket; generation of a first signal (5) and of a second signal (6), independently from each other, as a function of said input signal (3); generation of a third signal (10) having a frequency which is modulated by said first signal and an magnitude which is modulated by said second signal, and use of said third signal to drive said magnetostrictive device (2).

A method for controlling a prilling bucket in the prilling of a a urea melt (UM) including: feeding the urea melt to a prilling bucket (1) which vibrates under the action of a magnetostrictive device (2), wherein the vibration of the bucket is controlled, as a function of the amount of urea melt to be prilled, by the following steps: acquisition of a time-varying input signal (3) which represents the flow rate of urea melt fed to the prilling bucket; generation of a first signal (5) and of a second signal (6), independently from each other, as a function of said input signal (3); generation of a third signal (10) having a frequency which is modulated by said first signal and an magnitude which is modulated by said second signal, and use of said third signal to drive said magnetostrictive device (2).

A particle production apparatus includes a liquid droplet formation unit configured to discharge a liquid from a discharging hole to form a liquid droplet, and a particle formation unit configured to solidify the liquid droplet to form a particle. The particle formation unit includes a conveyance gas flow, and the liquid droplet formation unit is configured to discharge the liquid to satisfy Formula 1 below:

[00001]$\begin{array}{cc}P=\frac{\mathrm{Vj}}{\mathrm{Pd}0}\sqrt{\frac{\rho \mathrm{Vx}}{2A}}{\cos }^2\left(\theta -65\right)>1& \mathrm{Formula}1\end{array}$

In the Formula 1, Vj represents a velocity (m/s) of the liquid droplet to be discharged, F represents a discharging drive frequency (kHz), d0 represents a diameter (μm) of the liquid droplet, ρ represents a density (kg/m) of the liquid, Vx represents a velocity (m/s) of the conveyance gas flow, A represents shortest distance (m) from the liquid droplet formation unit to a center of the conveyance gas flow, and θ represents an angle (deg.) at which the liquid droplet is to be discharged.

A particle production apparatus includes a liquid droplet formation unit configured to discharge a liquid from a discharging hole to form a liquid droplet, and a particle formation unit configured to solidify the liquid droplet to form a particle. The particle formation unit includes a conveyance gas flow, and the liquid droplet formation unit is configured to discharge the liquid to satisfy Formula 1 below:

[00001]$\begin{array}{cc}P=\frac{\mathrm{Vj}}{\mathrm{Pd}0}\sqrt{\frac{\rho \mathrm{Vx}}{2A}}{\cos }^2\left(\theta -65\right)>1& \mathrm{Formula}1\end{array}$

In the Formula 1, Vj represents a velocity (m/s) of the liquid droplet to be discharged, F represents a discharging drive frequency (kHz), d0 represents a diameter (μm) of the liquid droplet, ρ represents a density (kg/m) of the liquid, Vx represents a velocity (m/s) of the conveyance gas flow, A represents shortest distance (m) from the liquid droplet formation unit to a center of the conveyance gas flow, and θ represents an angle (deg.) at which the liquid droplet is to be discharged.

Provided is a toner including at least: a binder resin; and a release agent, wherein in a transmission electron microscopic (TEM) image of a torn cross-section of the toner, the release agent has an acicular or filiform shape and an average aspect ratio of 31 or greater, and wherein a displacement amount of the toner when 250 micronewtons is applied to the toner in a microcompression test is 700 nm or less.

A device for granulating powders by cryogenic atomisation, characterised in that it comprises: a device for mixing powders by cryogenic fluid, comprising at least one chamber for mixing powders, comprising a cryogenic fluid; and a device for atomising a suspension of powders mixed by the device for mixing powders in order to allow a granulation of the powders, comprising a way of fractionating the suspension of powders making it possible to adjust the size of the droplets of powders to be atomised, and a method for adjusting the moisture of the mixed powders and/or the moisture of the atomisation atmosphere.

A device for granulating powders by cryogenic atomisation, characterised in that it comprises: a device for mixing powders by cryogenic fluid, comprising at least one chamber for mixing powders, comprising a cryogenic fluid; and a device for atomising a suspension of powders mixed by the device for mixing powders in order to allow a granulation of the powders, comprising a way of fractionating the suspension of powders making it possible to adjust the size of the droplets of powders to be atomised, and a method for adjusting the moisture of the mixed powders and/or the moisture of the atomisation atmosphere.