Microarrays, hybridization seals and related methods. An apparatus includes a substrate including a plurality of probes and a hybridization seal. The hybridization seal includes an evaporation barrier and a layer including walls that form a grid pattern and define a plurality of sample chambers that are to receive fluid. The layer includes a first side removably coupled to the substrate and a second side that is coupled to the evaporation barrier. The evaporation barrier includes barrier sections that cover the probes and include one or more slits that allow the barrier sections to have a convex profile or a concave profile depending on an amount of the fluid within the corresponding sample chamber.

Apparatuses and methods are described herein for processing polynucleotides in a sealed path environment. The apparatuses include optical sensors to monitor operations and to track material usage for good manufacturing practice.

Methods and apparatuses for making and using therapeutics, including in particular mRNA therapeutics, that separate double-stranded RNA from single-stranded RNA as part of a continuous flow. These methods and apparatuses may include formulation of an RNA therapeutic using a permeable insert integrated into a microfluidic path device. In particular, these methods and apparatuses may include formulation of an RNA therapeutic by removing dsRNA from a solution of RNA by within a microfluidic path device including a cellulose material.

An analysis system for testing a biological sample wherein a sensor cover can be or is pneumatically lowered onto a sensor apparatus in order to detect an analyte of the sample.

An analysis system for testing a biological sample wherein a sensor cover can be or is pneumatically lowered onto a sensor apparatus in order to detect an analyte of the sample. A sensor array having a plurality of sensor fields are fluidically separated from one another by lowering the sensor cover. The sensor apparatus has a housing that is sealingly mounted on the sensor cover in an edge region, the housing surrounding a chip or support of the sensor apparatus at least partially. The sensor cover has a raised portion in a center on a side remote or opposite from the sensor apparatus or is centrally reinforced.

Apparatuses and methods are described herein for processing polynucleotides in a sealed path environment. The apparatuses include optical sensors to monitor operations and to track material usage for good manufacturing practice.

Apparatuses and methods are described herein for processing polynucleotides in a sealed path environment. The apparatuses include optical sensors to monitor operations and to track material usage for good manufacturing practice.

Apparatuses and methods are described herein for processing polynucleotides in a sealed path environment. The apparatuses include optical sensors to monitor operations and to track material usage for good manufacturing practice.

The present disclosure provides methods, device, and system for wafer processing. The wafer processing apparatus uses a nozzle in a lid to disperse a solution to the surface of a wafer. Further, the wafer is positioned on top of a vacuum chuck and does not spin while the solution is dispensed over the surface of the wafer via surface tension, thereby permitting the first solution to react with a reagent on the surface. Further, when dispensing the first solution, a separation gap between the lid and the wafer is at a predetermined distance, for example, from about 20 ?m to about 2 mm.

The present disclosure provides methods, device, and system for wafer processing. The wafer processing apparatus uses lid dispenser to disperse at least one reagent to the surface of the wafer. Further, the wafer is positioned on top of a rotatable vacuum chuck configured to spread at least one reagent over the surface of the wafer via a centrifugal force or surface tension, thereby permitting the at least one reagent to react with an additional reagent. Further, when dispensing the at least one reagent, a separation gap between the lid dispenser and the wafer is at a predetermined distance, for example, from 50 m to 2 mm.