An elongate solid phase body suitable for performing solid phase synthesis. The solid phase body includes a plurality of enclosures formed of a material of a chemically inert mesh and, within each enclosure, a plurality of solid phase beads.

Systems, methods, and compositions for high throughput screening of micro-scale chemical reactions are disclosed. In particular, systems, methods, and compositions for handling small amounts of solid reagent are disclosed. For example, mechanical mixing is employed to obtain reagent-coated bulking agents that can be used, inter alia, in high throughput methods for screening micro-scale chemical reactions.

This invention relates to an elongate solid phase body suitable for performing solid phase synthesis. The solid phase body comprises a plurality of enclosures formed of a material comprising a chemically inert mesh and, within each enclosure, a plurality of solid phase beads.

Systems, methods, and compositions for high throughput screening of micro-scale chemical reactions are disclosed. In particular, systems, methods, and compositions for handling small amounts of solid reagent are disclosed. For example, mechanical mixing is employed to obtain reagent-coated bulking agents that can be used, inter alia, in high throughput methods for screening micro-scale chemical reactions.

A method for serial and contemporaneous synthesis of disparate deoxy-ribonucleic acid (DNA) strands in an array of wells defined within a substrate. Each well in the array of wells contains a precursor nucleotide chain. A first subset of wells of the array of wells is designated not to receive a nucleotide of a specified nucleobase type and the first subset of wells is closed. A solution of a binding reaction enzyme and nucleotides of the specified nucleobase type bound with a corresponding chemical blocker is flowed over the array of wells. Nucleotides of the specified nucleobase type are received in each of a second subset of wells of the array of wells that are open and designated to receive the nucleotide of the specified nucleobase type. Received nucleotides of the specified nucleobase type are bound with assistance of the binding reaction enzyme to corresponding precursor nucleotide chains in the second subset of wells.