The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.

Methods and devices are provided herein for surfaces for de novo nucleic acid synthesis which provide for low error rates. In addition, methods and devices are provided herein for increased nucleic acid mass yield resulting from de novo nucleic acid synthesis.

A method and apparatus for monitoring and evaluation of a production of a functional material, wherein an assessment of steps taken by users based on a data basis results in reporting to the user of the extent to which predetermined properties of a functional material produced are attained in the event of variances in the steps taken.

De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

The present invention discloses a method and apparatus for fully automated iterative polymer synthesis at a large scale.

Methods of liquid-phase synthesis of polymers using polymer substrates and systems for facilitating such methods allow gating of a synthetic reaction into a binary (reacted or unreacted) readout. Polymer substrates are used as carriers for molecular reagents and act as separation tags that allow them to be purified using nanoscale deterministic lateral displacement. Two polymer substrates are linked together by a bond-forming reaction to form a longer polymer that includes a synthetic product. The synthetic product can be purified away from unreacted polymers/reagents using strand-length dependent lateral displacement.

Process for the production of a product gas containing nitrogen and hydrogen from ammonia comprising the steps of non-catalytic partial oxidation of ammonia with an oxygen containing gas to a process gas containing nitrogen, water, amounts of nitrogen oxides and residual amounts of ammonia; cracking of at least a part of the residual amounts of ammonia to hydrogen and nitrogen in the process gas by contact with a nickel containing catalyst and simultaneously reducing the amounts of nitrogen oxides to nitrogen and water by reaction with a part of the hydrogen formed during cracking of the process gas by contact of the process gas with the nickel containing catalyst; and withdrawing the hydrogen and nitrogen containing product gas.

A synthesis device comprises a plurality of pipes, a feeding unit, a reaction vessel, and a measurement mechanism. The pipes extend from a plurality of storage containers, respectively, in which a plurality of types of solutions are stored. The feeding unit is configured to feed the solutions in the storage containers through the pipes. The solutions selectively fed from the storage containers are put in the reaction vessel to generate a synthesized product by chemical synthesis. The measuring mechanism is provided between the storage containers and the reaction vessel in a middle of an overall flow path including the pipes, the measuring mechanism being configured to measure the solutions fed to the reaction vessel.

Described herein are devices and methods of use thereof, the devices comprising: a sample conduit providing a path for fluid flow extending from a sample inlet to a sample outlet; a thermal housing enclosing the sample conduit, the thermal housing comprising a plurality of measurement regions; and a motorized stage translatable along the thermal housing so as to align a detector with one or more of the plurality of measurement regions. The devices can continuously flow a fluid precursor sample from the sample inlet to the sample outlet, the fluid precursor sample comprising a first precursor and a second precursor, such that the first precursor reacts with the second precursor as the fluid precursor sample continuously flows from the sample inlet to the sample outlet to form the sample before reaching the sample outlet, wherein the sample comprises a plurality of particles or an organic molecule.

De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.