A method and system for mechanical activation of organic and/or inorganic substances and/or substance mixtures in chemical, pharmaceutical, food acceptable applications and/or in applications useful for building purposes, includes feeding of a substance and/or substance mixture to be activated through an inlet opening into a container which stores activation bodies, feeding a process gas stream into the container, wherein the process gas stream can support transportation of the substance and/or substance mixture to be activated, mechanically activating the substance and/or substance mixture in the container by a rotating apparatus, wherein at least one beating unit of the apparatus interacts with the activation bodies, discharging the substance and/or substance mixture activated by the activation bodies from the container through an outlet opening, wherein the substance and/or substance mixture dwells in the container for a predetermined dwell time.