Disclosed herein are methods and apparatus for producing nanometer scale particles utilizing an electrosterically stabilized slurry in a media mill. A method for producing nanometer scale particles includes adding to a media mill a feed substrate suspension. The feed substrate suspension includes a liquid carrier medium and feed substrate particles. The method further includes adding to the feed substrate suspension in the media mill an electrosteric dispersant. The electrosteric dispersant includes a polyelectrolyte. Still further, the method includes operating the media mill for a period of time to comminute the feed substrate particles, thereby forming nanometer scale particles having a (D.sub.90) particle size of less than about one micron, and recirculating for further grinding the nanometer scale particles from the media mill.

The present invention relates to methods for producing particles of meloxicam using dry milling processes as well as compositions comprising meloxicam, medicaments produced using meloxicam in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of meloxicam administered by way of said medicaments.

The present invention relates to methods for producing particles of meloxicam using dry milling processes as well as compositions comprising meloxicam, medicaments produced using meloxicam in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of meloxicam administered by way of said medicaments.

Methods for disaggregating nanodiamond clusters, for example, by using sonication to break apart nanodiamond aggregates in an aqueous slurry having an alkaline pH. Compositions, such as aqueous nanodiamond dispersions and dry particulate compositions can be produced using these methods.

A method for grinding a solid in a vertical roller mill (VRM), comprising grinding at least one solid in the presence of a grinding stabilizing additive, wherein the grinding stabilizing additive comprises an alkanol amino acid compound or a disodium or dipotassium salt thereof having the structural formula (I): The definitions of variables R.sup.1, R.sup.2, and R.sup.3 are provided herein. ##STR00001##

A method for grinding a solid in a vertical roller mill (VRM), comprising grinding at least one solid in the presence of a grinding stabilizing additive, wherein the grinding stabilizing additive comprises an alkanol amino acid compound or a disodium or dipotassium salt thereof having the structural formula (I): The definitions of variables R.sup.1, R.sup.2, and R.sup.3 are provided herein. ##STR00001##

Powder composition comprising alkali metal bicarbonate particles and an amino acid as additive. A process for preparing alkali metal bicarbonate particles by spray-drying of an aqueous solution comprising 1-10% by weight of alkali metal bicarbonate and an amino acid as additive. A process for preparing alkali metal bicarbonate particles by co-grinding the alkali metal bicarbonate in the presence of an amino acid as additive.

Powder composition comprising alkali metal bicarbonate particles and an amino acid as additive. A process for preparing alkali metal bicarbonate particles by spray-drying of an aqueous solution comprising 1-10% by weight of alkali metal bicarbonate and an amino acid as additive. A process for preparing alkali metal bicarbonate particles by co-grinding the alkali metal bicarbonate in the presence of an amino acid as additive.

A planetary roller mill for processing a feed material includes a vessel with a grinding ring having an opening therethrough and a first area. The grinding ring is in sealing engagement with the inside surface of the vessel assembly. At least two non-circular support plates are secured to a rotatable shaft. Each plate has an axially facing surface. A plurality of rollers rotatably are mounted to and positioned between the two support plates. Each of the plurality of rollers are in grinding communication with the grinding surface. The planetary roller mill includes an air supply system having an outlet in communication with the opening in the grinding ring. Areas of the two support plates are of magnitudes which configure a flow area through the opening of at least 30 percent of the first area to provide a predetermined quantity of heated air to remove moisture from the feed material in the grinding assembly.

A planetary roller mill for processing a feed material includes a vessel with a grinding ring having an opening therethrough and a first area. The grinding ring is in sealing engagement with the inside surface of the vessel assembly. At least two non-circular support plates are secured to a rotatable shaft. Each plate has an axially facing surface. A plurality of rollers rotatably are mounted to and positioned between the two support plates. Each of the plurality of rollers are in grinding communication with the grinding surface. The planetary roller mill includes an air supply system having an outlet in communication with the opening in the grinding ring. Areas of the two support plates are of magnitudes which configure a flow area through the opening of at least 30 percent of the first area to provide a predetermined quantity of heated air to remove moisture from the feed material in the grinding assembly.