B04B1/12

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

METHOD AND PROCESS LINE FOR PRODUCING A DEWATERED GLUTEN-CONTAINING FRACTION
20220153788 · 2022-05-19 ·

A method for producing a dewatered gluten-containing fraction involves providing a gluten-containing fraction, concentrating the gluten-containing fraction by centrifugal processing according to a determined dry substance content, adjusting the pH value and the temperature of the concentrated gluten-containing fraction by a temperature-control and metering unit, and dewatering the concentrated gluten-containing fraction.

METHOD AND PROCESS LINE FOR PRODUCING A DEWATERED GLUTEN-CONTAINING FRACTION
20220153788 · 2022-05-19 ·

A method for producing a dewatered gluten-containing fraction involves providing a gluten-containing fraction, concentrating the gluten-containing fraction by centrifugal processing according to a determined dry substance content, adjusting the pH value and the temperature of the concentrated gluten-containing fraction by a temperature-control and metering unit, and dewatering the concentrated gluten-containing fraction.

SEPARATOR
20220134357 · 2022-05-05 ·

A separator includes a housing that is stationary during operation and is a tank having at least two openings. A drum is located inside the housing, has a vertical axis of rotation, and a number of openings to the housing corresponding to the openings of the housing. A single multi-part support and drive device with at least one control device and a motor including of a stator, a stator magnet assembly, and a rotor with a rotor magnet assembly, which keep the drum suspended inside the housing, radially and axially supported, and set in rotation. The stator magnet assembly is located outside the housing and the rotor magnet assembly is located inside the housing on the drum so that an air gap is formed between the housing and the drum while the drum is rotating during operation. The axial support and centering of the drum is implemented by controlling the axial position of the rotor magnet assembly using the control device by actuating the motor.

APPARATUS FOR PRODUCING POTABLE WATER

The invention provides an apparatus for providing potable water, which apparatus comprises a plurality of components linked in series to provide a flow path through the apparatus, wherein the plurality of components comprises: (i) an inlet (4) for a stream of contaminated water requiring purification; (ii) a centrifugal separator (20) for separating the contaminated water stream into a partially purified water stream and a contaminant stream; (iii) a pre-filter pump (26); (iv) a pre-filter pressure sensor (30); (v) a first filter assembly (32) comprising one or more filter modules for removing particles of a predetermined size and/or removing organic contaminants from the partially purified water stream; (vi) a post-filter pressure sensor (38); (vii) a post-filter pump (40); (viii) a second filter assembly comprising one or more reverse osmosis filters (48); (ix) a UV steriliser unit (52); and (x) an outlet (6) for purified potable water; and wherein the apparatus further comprises an electronic controller (14) for controlling and monitoring the operation of the apparatus.

APPARATUS FOR PRODUCING POTABLE WATER

The invention provides an apparatus for providing potable water, which apparatus comprises a plurality of components linked in series to provide a flow path through the apparatus, wherein the plurality of components comprises: (i) an inlet (4) for a stream of contaminated water requiring purification; (ii) a centrifugal separator (20) for separating the contaminated water stream into a partially purified water stream and a contaminant stream; (iii) a pre-filter pump (26); (iv) a pre-filter pressure sensor (30); (v) a first filter assembly (32) comprising one or more filter modules for removing particles of a predetermined size and/or removing organic contaminants from the partially purified water stream; (vi) a post-filter pressure sensor (38); (vii) a post-filter pump (40); (viii) a second filter assembly comprising one or more reverse osmosis filters (48); (ix) a UV steriliser unit (52); and (x) an outlet (6) for purified potable water; and wherein the apparatus further comprises an electronic controller (14) for controlling and monitoring the operation of the apparatus.

Single use tubing set for making genetically modified donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Single use tubing set for making genetically modified donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Device and procedure for producing a cellular pharmaceutical product enriched in genetically modified target cells at the bedside or in a surgical room

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Device and procedure for producing a cellular pharmaceutical product enriched in genetically modified target cells at the bedside or in a surgical room

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.