Patent classifications
B04B1/12
PREPARING ANTIGEN-SPECIFIC T CELLS USING A SELF-ENCLOSED PROCESSING SYSTEM THAT CONTAINS BOTH A CENTRIFUGE AND A MAGNETIC SEPARATION COLUMN
The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
Outlet nozzle for a centrifugal drum, centrifugal drum and assembly tool
An outlet nozzle for centrifugal drums has a nozzle body with at least one cylindrical portion and having an insert connected to the nozzle body. An inlet channel and an outlet channel, which is oriented at an angle with respect to the inlet channel, are formed in the nozzle body. The insert has a torque transmitting contour for arranging a tool with a complementary tool torque transmitting contour in position in order to rotatingly secure the nozzle body in an opening of a rotatable centrifugal drum and to release said nozzle body. The insert also has a polygonal cross-section, which is smaller than the cross-section of the cylindrical section. The insert starting from the polygonal, in particular, rectangular cross-section, merges with the cylindrical section of the nozzle body over rounded surfaces having a radius greater than 1.0 mm.
Outlet nozzle for a centrifugal drum, centrifugal drum and assembly tool
An outlet nozzle for centrifugal drums has a nozzle body with at least one cylindrical portion and having an insert connected to the nozzle body. An inlet channel and an outlet channel, which is oriented at an angle with respect to the inlet channel, are formed in the nozzle body. The insert has a torque transmitting contour for arranging a tool with a complementary tool torque transmitting contour in position in order to rotatingly secure the nozzle body in an opening of a rotatable centrifugal drum and to release said nozzle body. The insert also has a polygonal cross-section, which is smaller than the cross-section of the cylindrical section. The insert starting from the polygonal, in particular, rectangular cross-section, merges with the cylindrical section of the nozzle body over rounded surfaces having a radius greater than 1.0 mm.
CONTINUOUS CENTRIFUGAL DEWATERING DEVICE
Disclosed is a continuous centrifugal dewatering device including an external case having an internal space, a feed supply pipe to which a slurry as a mixture of a solid and a liquid is supplied, a basket provided inside the external case, a plurality of holes formed in the basket, a pusher plate provided inside the basket and configured to discharge a slurry cake attached to an inner circumferential surface of the basket to the outside of the external case, a non-contact seal configured to prevent the first gas from flowing into a space between the external case and the basket, and a gas inlet to which a second gas, which flows in a reverse direction with respect to a flow direction of the first gas flowing to the space between the external case and the basket, is supplied.
CONTINUOUS CENTRIFUGAL DEWATERING DEVICE
Disclosed is a continuous centrifugal dewatering device including an external case having an internal space, a feed supply pipe to which a slurry as a mixture of a solid and a liquid is supplied, a basket provided inside the external case, a plurality of holes formed in the basket, a pusher plate provided inside the basket and configured to discharge a slurry cake attached to an inner circumferential surface of the basket to the outside of the external case, a non-contact seal configured to prevent the first gas from flowing into a space between the external case and the basket, and a gas inlet to which a second gas, which flows in a reverse direction with respect to a flow direction of the first gas flowing to the space between the external case and the basket, is supplied.
DEVICES AND DISPOSABLES FOR PATIENT-SPECIFIC CELL THERAPY MANUFACTURING
The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
DEVICES AND DISPOSABLES FOR PATIENT-SPECIFIC CELL THERAPY MANUFACTURING
The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
Nanoparticle Mass Purification System and Nanoparticle Mass Purification Method Using Same
The present invention provides a nanoparticle mass purification system capable of purifying nanoparticles at high yield and high purify from a nanoparticle synthesis stock solution synthesized in large quantities, and reusing the used solvent by recovery, and a nanoparticle mass purification method using same.
Nanoparticle Mass Purification System and Nanoparticle Mass Purification Method Using Same
The present invention provides a nanoparticle mass purification system capable of purifying nanoparticles at high yield and high purify from a nanoparticle synthesis stock solution synthesized in large quantities, and reusing the used solvent by recovery, and a nanoparticle mass purification method using same.
Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient
The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.