A centrifugal separation container which is revolved around a rotation axis, includes: a separation part which includes a distal region which is disposed on a distal side than a liquid-to-be-treated supply port and a proximal region which is disposed on a proximal side than the liquid-to-be-treated supply port, with respect to the rotation axis, and in which a liquid-to-be-treated discharge port is provided in the proximal region; and a recovery part which is disposed on a distal side than the distal region with respect to the rotation axis, communicates with a distal end portion of the distal region through a communication path, and is filled with a recovery liquid for dispersing dispersoids that are to be centrifuged in a liquid to be treated.

A blood bag system includes a BC pooling bag for centrifugation of a buffy coat, a filter for removing white blood cells from a supernatant liquid transferred from the BC pooling bag, a platelet preserving bag for reserving the supernatant liquid that has passed through the filter, a first tube connecting the BC pooling bag and an inlet of the filter, a second tube connecting the platelet preserving bag and an outlet of the filter, and a cassette to be fixed in the centrifugation and separation apparatus. The first tube and the second tube are disposed within the cassette. The cassette includes a first clamp section for closing and opening the first tube, and a second clamp section for closing and opening the second tube.

An enclosed centrifugation device is provided, including an integrated tube body that includes an upper part, a middle part, and a lower part, wherein the upper part is configured to have multiple openings each having an open state and a closed state. The openings that are used for sealed connection to external tubing, include the first opening serving as a liquid inlet and the second opening serving as a liquid outlet. Also provided is a method for segregating cells. The enclosed centrifugation device provided by the present invention can centrifuge cell suspension and realize rapid inlet, outlet, or replacement of liquid in an enclosed setting, which greatly reduces the risk of being contaminated for biological sample, and simultaneously meets the requirement by regulations that sample treatment by Class III medical devices must be fully enclosed.

Apparatus and methods for point-of-care red blood cell washing are disclosed. One method of filtering a suspension of red blood cells may generally comprise introducing a wash solution to the suspension of red blood cells such that a combined volume is retained within a first compartment, applying a sweeping action upon the volume, applying a pressure upon the volume while applying the sweeping action such that the volume is urged through a filter membrane at a predetermined filtration rate, maintaining the filtration rate over a predetermined period of time such that hemolysis is maintained below a threshold level, and collecting the volume within a second compartment.

A portable centrifuge comprising a base, which includes a rotational mechanism contained within. A sequester wheel having a plurality of concentric rings, forming at least one channel and a central container. The at least one channel comprising a second volume and the central container comprising a first volume. A first cover is disposed over the sequester wheel to create a seal. A second cover is disposed over the first cover and is rotatable to engage with the rotational mechanism to initiate rotation at a predetermined RPM. The whole blood, tissue or other cell types are separated into its constituent components and deposited into the at least one channel and the central container. Specific volumes of the constituent components, tissue and/or cell types may be calculated to match or substantially match the first and second volumes for predetermined volume control and ease of access.

A chamber for centrifugal separation includes a chamber body having an upper opening and a lower opening opposite to the upper opening, an upper cover having an upper injection port and mounted on a chamber main body to cover the upper opening, a lower cover having a lower injection port and mounted on the chamber body to cover the lower opening, a receiving space provided in the chamber main body, and including a first receiving part communicating with the lower injection port and an extracting part extending upward from the first receiving part and having a section area smaller than a sectional area of the first receiving part, and a remaining liquid receiving space provided in the chamber main body to receive a material flowing over the receiving space, as the material is injected into the receiving space from the lower injection port.

A chamber for centrifugal separation includes a main body including a first opening and a second opening opposite to the first opening, a first cover coupled to the main body to close the first opening and including a first injection port to inject a material, a second cover coupled to the main body to close the second opening and including a second injection port to inject a material, and a filter device provided inside the main body and interposed between the first injection port and the second injection port, to prevent the material injected into the first injection port from being mixed with the material injected into the second injection port.

Plasma/cell concentrator apparatus and methods are described herein for concentrating constituents from a fluid. Generally, a volume of the fluid may be urged from a first reservoir to a second reservoir through a fluid channel and a volume of desiccant for mixing with the fluid may be introduced to create a mixture. This fluid and desiccant mixture may be passed between the first and second reservoirs until one or more components from the fluid are absorbed by the desiccant. After mixing, the fluid may be withdrawn through a withdrawal channel which is in fluid communication with the fluid channel while preventing the desiccant from passing into the withdrawal channel.

Provided is a centrifuge including: a rotary chamber configured to rotate so that centrifugal force acts on a substance contained in the rotary chamber; a storage unit configured to store a certain component separated from the substance in the rotary chamber by the centrifugal force according to rotation of the rotary chamber; and a filter located between the storage unit and the rotary chamber and through which the certain component, which is separated from the substance in the rotary chamber by the centrifugal force according to the rotation of the rotary chamber, passes to be stored in the storage unit. The storage unit includes a return prevention unit configured to prevent the certain component, which is separated from the substance in the rotary chamber by the centrifugal force according to the rotation of the rotary chamber and is stored in the storage unit, from returning from the storage unit to the rotary chamber. The present disclosure has an effect of easily separating a certain component sought to be separated.

A device that allows for either fat graft preparation or cell fraction harvest is disclosed. The device includes a first centrifuge tube configured to receive and process a biological substance, the first centrifuge tube comprising an upper cylindrical portion and a lower conical portion, a sterile tissue inlet fitting, at least one sterile processing fluid inlet fitting, a sterile suction fitting, and at least one sterile extraction port connected to a first extraction tube. The first centrifuge tube further includes an internal space including a screen being positioned therein, the screen being configured to divide the internal space in half, and a filter positioned therein, the filter being positioned below the screen in the lower conical portion of the first centrifuge tube. The device may further include a second centrifuge tube configured to receive and further process the biological substance from the first centrifuge tube. The second centrifuge tube has at least one sterile fitting, wherein the second centrifuge tube is releasably connected via the at least one sterile fitting to one of the at least one sterile extraction ports of the first centrifuge tube.