The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.

The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.

An industrial centrifuge for extracting one or more compounds from biomass includes a centrifuge basket disposed within a cylindrical vessel. The centrifuge basket includes a cylindrical sidewall comprising an upper perforated portion and a lower solid portion and a basket baseplate coupled to the sidewall between the upper perforated portion and the lower solid portion. The centrifuge includes a spindle coupled to the basket baseplate, a spindle bearing assembly, and a contact seal disposed between the spindle bearing assembly and the basket baseplate. The lower solid portion of the sidewall, the spindle, and the basket baseplate define a skirted volume. During operation of the industrial centrifuge, air trapped within the skirted volume provides an air seal between an extraction fluid in the cylindrical vessel and the contact seal, spindle bearing assembly, or both, to prevent extraction fluid from contacting the spindle bearings and causing damage thereto.

A centrifuge basket includes a frustum-shaped hollow body defining a pair of opposed ends, being a larger end and a smaller end. The body defines an internal screening surface extending between the ends, the screening surface defining a plurality of apertures arranged to drain liquid from within the body. A plurality of ribs project into an interior of the body from the screening surface, the ribs being arranged in a plurality of annular arrays. The arrays are spaced axially along the screening surface and the ribs of at least one of the arrays are arranged transversely, at a defined included angle, relative to a generatrix line that forms a shape of the screening surface.

A centrifuge basket includes a frustum-shaped hollow body defining a pair of opposed ends, being a larger end and a smaller end. The body defines an internal screening surface extending between the ends, the screening surface defining a plurality of apertures arranged to drain liquid from within the body. A plurality of ribs project into an interior of the body from the screening surface, the ribs being arranged in a plurality of annular arrays. The arrays are spaced axially along the screening surface and the ribs of at least one of the arrays are arranged transversely, at a defined included angle, relative to a generatrix line that forms a shape of the screening surface.

A sieve panel and related methods of construction for dewater slurries with shaped-wire elements that have a variable tilt arrangement along the sieve panel. Each of the plurality of shaped-wire elements can be selectively oriented when mounted to a support member to define a desired tilt angle of the shaped-wire element relative to the support members Tilt angle can be selectively varied between an upper end and a lower end of the sieve panel to enhance dewatering characteristics of the sieve panel. The sieve panel can be fabricated such that an upper portion and a lower portion are essentially mirror images of each other such that the sieve panel can be flipped after leading edges of the individual screening elements have suffered wear leading to a degradation in dewatering performance. By flipping the sieve panel, an effective service life of the sieve panel can be essentially doubled.

The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.

The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.

The present invention relates, in part, to methods, systems and processes for large-scale purification of mRNA using a filtering centrifuge operating at lower gravitational forces. The invention also relates to compositions of purified mRNA and uses thereof.

The present invention relates, in part, to methods, systems and processes for large-scale purification of mRNA using a filtering centrifuge operating at lower gravitational forces. The invention also relates to compositions of purified mRNA and uses thereof.