A centrifugal field-flow fractionation device is provided with a controller for controlling introduction of a liquid sample by a sample introduction part and rotation of the rotor by a motor. The controller rotates the rotor at a first rotational speed when introducing the liquid sample into a flow path. The first rotational speed is faster than a second rotational speed. Therefore, when a liquid sample is introduced into the flow path, high centrifugal force can be applied to the liquid sample, which can suppress the variation of the particles in the liquid sample introduced to the flow path. The controller rotates the rotor at the second rotational speed slower than the first rotational speed with the liquid sample flow in the flow path stopped. Therefore, it is possible to prevent the constant application of high centrifugal force to the liquid sample, thereby suppressing the increase in the length of time required for analysis.

A centrifugal field-flow fractionation device is provided with a controller for controlling introduction of a liquid sample by a sample introduction part and rotation of the rotor by a motor. The controller rotates the rotor at a first rotational speed when introducing the liquid sample into a flow path. The first rotational speed is faster than a second rotational speed. Therefore, when a liquid sample is introduced into the flow path, high centrifugal force can be applied to the liquid sample, which can suppress the variation of the particles in the liquid sample introduced to the flow path. The controller rotates the rotor at the second rotational speed slower than the first rotational speed with the liquid sample flow in the flow path stopped. Therefore, it is possible to prevent the constant application of high centrifugal force to the liquid sample, thereby suppressing the increase in the length of time required for analysis.

A portable motorized centrifugal system is optimized for low cost manufacture and operation. Separation of inhomogeneous fluid biological samples, such as liquid plasma from whole blood, is a common step in medical diagnostic tests. This system may enable remote separation where access to plug-in power sources are limited. The system may facilitate at-home testing. Due to biohazard concerns, the entire centrifugal apparatus portable and disposable, or the system includes one or more disposable elements within the interior of the centrifuge. Alternatively, the system may contain a module of higher value components that are re-usable after disinfection. Devices and methods for implementing centrifugal separation may include disk-shaped fluidic cartridges and tubes with reduced drag cross-section.

A portable motorized centrifugal system is optimized for low cost manufacture and operation. Separation of inhomogeneous fluid biological samples, such as liquid plasma from whole blood, is a common step in medical diagnostic tests. This system may enable remote separation where access to plug-in power sources are limited. The system may facilitate at-home testing. Due to biohazard concerns, the entire centrifugal apparatus portable and disposable, or the system includes one or more disposable elements within the interior of the centrifuge. Alternatively, the system may contain a module of higher value components that are re-usable after disinfection. Devices and methods for implementing centrifugal separation may include disk-shaped fluidic cartridges and tubes with reduced drag cross-section.

An oil centrifuge has an integral, rotatably mounted centrifuge rotor and a feed tube connected to the centrifuge rotor. A flow path is provided that supplies oil to the centrifuge rotor. The feed tube is a section of the flow path. The flow path has a throttle point having a reduced throttle cross section that is reduced relative to an upstream flow path cross section of the flow path upstream of the throttle point.

An oil centrifuge has an integral, rotatably mounted centrifuge rotor and a feed tube connected to the centrifuge rotor. A flow path is provided that supplies oil to the centrifuge rotor. The feed tube is a section of the flow path. The flow path has a throttle point having a reduced throttle cross section that is reduced relative to an upstream flow path cross section of the flow path upstream of the throttle point.

A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow. The device includes a vented upstream chamber having an outlet port and an unvented chamber including an inlet port to receive liquid from the outlet port of the upstream chamber and an outlet port radially outward the inlet port. The device further includes a vented downstream chamber having an inlet port to receive liquid from the outlet port of the unvented chamber. A downstream conduit connects the outlet port of the unvented chamber to the inlet port of the downstream chamber and includes a bend radially inward of the outlet port of the unvented chamber. An upstream conduit connects the outlet port of the upstream chamber to the inlet port of the unvented chamber.

A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow. The device includes a vented upstream chamber having an outlet port and an unvented chamber including an inlet port to receive liquid from the outlet port of the upstream chamber and an outlet port radially outward the inlet port. The device further includes a vented downstream chamber having an inlet port to receive liquid from the outlet port of the unvented chamber. A downstream conduit connects the outlet port of the unvented chamber to the inlet port of the downstream chamber and includes a bend radially inward of the outlet port of the unvented chamber. An upstream conduit connects the outlet port of the upstream chamber to the inlet port of the unvented chamber.

A centrifuge includes a chamber configured to contain a set of one or more samples, an image sensor configured to generate image data, and processing circuitry. The processing circuitry is configured to: initiate centrifugation of the set of samples about a central axis; obtain a set of image data generated by the image sensor during centrifugation of the set of samples; and for each respective sample of the set of samples, apply a machine learning model configured to generate, based on image data representative of the respective sample in the set of image data, a viability score for the respective sample; determine whether the viability score for the respective sample satisfies a viability condition; and output whether the viability score for the respective sample satisfies the viability condition.

A centrifuge includes a chamber configured to contain a set of one or more samples, an image sensor configured to generate image data, and processing circuitry. The processing circuitry is configured to: initiate centrifugation of the set of samples about a central axis; obtain a set of image data generated by the image sensor during centrifugation of the set of samples; and for each respective sample of the set of samples, apply a machine learning model configured to generate, based on image data representative of the respective sample in the set of image data, a viability score for the respective sample; determine whether the viability score for the respective sample satisfies a viability condition; and output whether the viability score for the respective sample satisfies the viability condition.