Tooling fixture includes an installation mount, a rail fixed to the installation mount and a pair of movable jaws which can be clamped or loosened relative to each other and are fixed on the rail. A clamping drive structure for clamping the movable jaws is connected to the movable jaws. The clamping drive mechanism includes a screw and a screw nut matched with the screw. The movable jaws are connected with the screw nut respectively. The screw is rotated, and the movable jaws move relatively to clamp or loosen the work piece. By the cooperation of the screw and the nut, the movable jaws slide on the rail to effectively clamp the work piece. In addition, the number of movable jaws can be set on demand so that they are matched with the screw and the screw nut.