A method of manufacturing a microfluidic architecture having at least one channel disposed therein. Steps can include pouring an uncured polymeric material into a mould to produce a first layer; at least partially curing the first layer; and forming the at least one channel by disposing a support material on the first layer; pouring an uncured polymeric material onto the first layer to form a second layer to thereby encapsulate the support material; and at least partially curing the second layer such that the first layer and second layer together form the microfluidic architecture; wherein the support material undergoes a phase change during the process of forming the at least one channel. The phase change of the support material enables the material to be more easily disposed and/or removed after formation of the channel.

A reusable countertop mold in accordance with the present invention includes a bracket member detachably secured to a rail portion of a cabinet member for a substantially horizontal substrate that receives deformable material upon a surface of the substrate. The bracket member includes vertical, horizontal and channel members integrally joined together for enabling a channel member to removably receive the rail member. The mold further includes a locking bolt for detachably securing the bracket member to the rail portion of the support member. A form member is detachably secured to the bracket member, the form member continuously extending outside the perimeter of the substrate and receives deformable material that ultimately solidifies; whereby, the substrate surface and the form member cooperate to configure a countertop that continuously extends upon and outside the perimeter of the substrate, thereby forming a countertop having an integrally joined overhang portion; whereupon, the reusable countertop mold is removed from the solidified countertop overhang portion and the rail portion.

A reusable countertop mold in accordance with the present invention includes a bracket member detachably secured to a rail portion of a cabinet member for a substantially horizontal substrate that receives deformable material upon a surface of the substrate. The bracket member includes vertical, horizontal and channel members integrally joined together for enabling a channel member to removably receive the rail member. The mold further includes a locking bolt for detachably securing the bracket member to the rail portion of the support member. A form member is detachably secured to the bracket member, the form member continuously extending outside the perimeter of the substrate and receives deformable material that ultimately solidifies; whereby, the substrate surface and the form member cooperate to configure a countertop that continuously extends upon and outside the perimeter of the substrate, thereby forming a countertop having an integrally joined overhang portion; whereupon, the reusable countertop mold is removed from the solidified countertop overhang portion and the rail portion.

A method of forming a device of composite material includes providing a mold having an internal space forming a cavity with an inner surface, the cavity having a shape corresponding to an inner shape of the device to be formed, placing inserts at one or more pre-defined positions along the inner surface, holding the inserts at the one or more positions, introducing removable material into the cavity of the mold to form a pattern having the inserts fixed therein when the removable material is in solid form, and removing the pattern having the inserts fixed therein from the mold.

A reusable countertop mold in accordance with the present invention includes a bracket member detachably secured to a rail portion of a cabinet member for a substantially horizontal substrate that receives deformable material upon a surface of the substrate. The bracket member includes vertical, horizontal and channel members integrally joined together for enabling a channel member to removably receive the rail member. The mold further includes a locking bolt for detachably securing the bracket member to the rail portion of the support member. A form member is detachably secured to the bracket member, the form member continuously extending outside the perimeter of the substrate and receives deformable material that ultimately solidifies; whereby, the substrate surface and the form member cooperate to configure a countertop that continuously extends upon and outside the perimeter of the substrate, thereby forming a countertop having an integrally joined overhang portion; whereupon, the reusable countertop mold is removed from the solidified countertop overhang portion and the rail portion.

A reusable countertop mold in accordance with the present invention includes a bracket member detachably secured to a rail portion of a cabinet member for a substantially horizontal substrate that receives deformable material upon a surface of the substrate. The bracket member includes vertical, horizontal and channel members integrally joined together for enabling a channel member to removably receive the rail member. The mold further includes a locking bolt for detachably securing the bracket member to the rail portion of the support member. A form member is detachably secured to the bracket member, the form member continuously extending outside the perimeter of the substrate and receives deformable material that ultimately solidifies; whereby, the substrate surface and the form member cooperate to configure a countertop that continuously extends upon and outside the perimeter of the substrate, thereby forming a countertop having an integrally joined overhang portion; whereupon, the reusable countertop mold is removed from the solidified countertop overhang portion and the rail portion.

A method employs a first polymeric material to deposit first and second pattern layers laterally shifted from each other such that laterally shifted pattern layers form between them an empty volume with a variable cross-section that varies along with the first and second pattern layers. A second polymeric material is cast in the empty volume between the first and second pattern layers to cast a complex-shaped 3D object identical in shape to the empty volume between the first and second pattern layers. Radiation is applied to cure the first and second polymeric materials. The first polymeric material is a water breakable material composition including acrylamide, methacrylamide, acrylate, acrylic acids, and acrylic acid salts, hydroxy(meth)acrylate, carboxy(meth)acrylate, acrylonitrile, carbohydrate monomers, methacrylate and polyfunctional acrylics.

A method employs a first polymeric material to deposit first and second pattern layers laterally shifted from each other such that laterally shifted pattern layers form between them an empty volume with a variable cross-section that varies along with the first and second pattern layers. A second polymeric material is cast in the empty volume between the first and second pattern layers to cast a complex-shaped 3D object identical in shape to the empty volume between the first and second pattern layers. Radiation is applied to cure the first and second polymeric materials. The first polymeric material is a water breakable material composition including acrylamide, methacrylamide, acrylate, acrylic acids, and acrylic acid salts, hydroxy(meth)acrylate, carboxy(meth)acrylate, acrylonitrile, carbohydrate monomers, methacrylate and polyfunctional acrylics.

Fluid transfer assemblies for transferring fluid into or out of a single vessel and distributing the fluid to multiple other vessels are provided. The fluid transfer assemblies are customizable, substantially aseptic, and single-use. The fluid transfer assemblies may be manufactured by solidifying polymeric materials to form a body around a mandrel with protrusions engaged to fluid conduits and leaving recesses in the solidified polymeric material to stretch the resultant body and remove the mandrel with protrusions. The resultant fluid transfer assembly may be surrounded by a rigid housing and valves may be engaged with the conduits and/or body to control the fluid flow within the fluid transfer assembly.

Fluid transfer assemblies for transferring fluid into or out of a single vessel and distributing the fluid to multiple other vessels are provided. The fluid transfer assemblies are customizable, substantially aseptic, and single-use. The fluid transfer assemblies may be manufactured by solidifying polymeric materials to form a body around a mandrel with protrusions engaged to fluid conduits and leaving recesses in the solidified polymeric material to stretch the resultant body and remove the mandrel with protrusions. The resultant fluid transfer assembly may be surrounded by a rigid housing and valves may be engaged with the conduits and/or body to control the fluid flow within the fluid transfer assembly.