Even when the filling speed increases, the surface temperature of a molded bottle falls within a constant range, and a sterilizer adequately sterilizes the bottle.

A preform is heated, the heated preform is sealed in a mold, the preform sealed in the mold is blow-molded into a bottle, the surface temperatures of a neck portion, a body portion, and a bottom portion of the molded bottle are measured, and the mold temperatures of a neck portion, a body portion, and a bottom portion of the mold is so adjusted that the measured surface temperature of the bottle falls within a specified temperature range.

Ways for simultaneously forming and filling a container with a product are provided that include a mold cavity, a two-stage injection unit, and a blow nozzle. The mold cavity defines an internal surface and is configured to accept a preform. The two-stage injection unit receives and dispenses the product where a first stage includes an extruder and a second stage includes an accumulator. The extruder imparts mechanical energy to the product to reduce a viscosity of the product and transfers the reduced-viscosity product to the accumulator. The accumulator receives the reduced-viscosity product from the extruder and dispenses a charge of the reduced-viscosity product. The blow nozzle transfers the charge of the reduced-viscosity product dispensed from the accumulator into the preform to urge the preform to expand toward the internal surface of the mold cavity and form a resultant container.

Systems and methods for automatic and dynamic temperature adjustment and over-cooling of a rotary Blow-Fill-Seal (BFS) manufacturing device to reduce the fill product temperature such as for filling of BFS vials with cold-temperature vaccines.

Systems and methods for rotary Blow-Fill-Seal (BFS) mold positioning that utilize fixed-position filling mandrels and upward moving molds to form mandrel-molded BFS product features utilizing a modified mold positioning path profile.

Ways for simultaneously forming and filling a container with a product are provided that include a mold cavity, a two-stage injection unit, and a blow nozzle. The mold cavity defines an internal surface and is configured to accept a preform. The two-stage injection unit receives and dispenses the product where a first stage includes an extruder and a second stage includes an accumulator. The extruder imparts mechanical energy to the product to reduce a viscosity of the product and transfers the reduced-viscosity product to the accumulator. The accumulator receives the reduced-viscosity product from the extruder and dispenses a charge of the reduced-viscosity product. The blow nozzle transfers the charge of the reduced-viscosity product dispensed from the accumulator into the preform to urge the preform to expand toward the internal surface of the mold cavity and form a resultant container.

This invention relates to a container (1) which is pre-filled or pre-fillable with one or more substances, such as a medical liquid and similar, comprising a squeezable activation compartment (2) intended to contain said one or more substances, a dispensing compartment (3) including a first portion (31) equipped with at least one dispensing member (311, 312, 314) of said one or more substances, and a second portion (32), wherein said second portion (32) of said dispensing compartment (3) and said activation compartment (2) are fluid-dynamically connected, and an activator element (4) arranged inside said container (1). This invention also relates to a method for dispensing at least one substance by means of a container (1), and to a production method of a container (1).