A bioprocessing system comprising a series of processing stations for performing operations for bioprocessing is disclosed. The bioprocessing system includes an automated system comprising means for manipulating a fluid connection between a first container and a separable second container whereby to create an aseptic connection that enables a controlled transfer of fluid or cell material between the first container and the second container, wherein the means for manipulating a fluid connection is configured to create an aseptic connection that can be disconnected after the transfer of fluid or cell material is complete to enable a further such fluid connection to be manipulated between the first container and a separable third container, and means for controlling an automated sequence of operation of the processing stations.

A sterile connection device includes first and second carriages. The first carriage defines a first portion of a proximal slot and a first portion of a distal slot, while the second carriage defines second portions of the proximal and distal slots. A controller executes a sterile connection procedure in which a solid cutting blade is heated, followed by the heated blade being moved to a cutting position to cut sealed proximal and distal tubes received by the slots. The second carriage moves proximally or distally with respect to the first carriage so as to align the cut ends of the tubes. The heated blade then moves out of the cutting position, followed by the first carriage moving toward the second carriage so as to press the cut ends of the tubes into contact with each other so as to sterilely connect the cut ends and define a joined tube.

A device for welding thermoplastic tubes to a welding method, and to a welding knife. The device is provided for welding thermoplastic tubes, wherein the tubes are placed into tube holders and squeezed with the aid of tube clamps. A welding knife is moved between the first and the second tube holder and severs the tubes in the process. Cut ends and residual ends are thereby produced. The cut ends are aligned with one another by a relative movement of one tube holder with respect to the other tube holder and, by a horizontal movement of the two tube holders, are welded simultaneously to form continuous tubes.

A sterile connection device includes first and second carriages. The first carriage defines a first portion of a proximal slot and a first portion of a distal slot, while the second carriage defines second portions of the proximal and distal slots. A controller executes a sterile connection procedure in which a solid cutting blade is heated, followed by the heated blade being moved to a cutting position to cut sealed proximal and distal tubes received by the slots. The second carriage moves proximally or distally with respect to the first carriage so as to align the cut ends of the tubes. The heated blade then moves out of the cutting position, followed by the first carriage moving toward the second carriage so as to press the cut ends of the tubes into contact with each other so as to sterilely connect the cut ends and define a joined tube.

A tube joining device includes a delivery with a first pusher member providing forward movement and backward movement along a delivery direction and delivering a wafer to a first position between a take-out position and a stand-by position, and with a second pusher member providing forward movement and backward movement along the delivery direction in combination with the first pusher member, and the wafer from the first position to the stand-by position.

The invention relates to a method and to a device for producing a butt-welded joint between two pipe segments (38, 39) of a pipe (27, 28) made of a weldable plastic material, each pipe segment being held by a gripping means (14, 15), pipe end cross-sections of the pipe segments (38, 39) being machined with the aid of a tool means (11) for forming welding contact surfaces (40, 41), said tool means (11) being disposed in a stationary manner in a separating plane (37) for machining the welding contact surfaces (40, 41) and a separating cut for forming the pipe segments (38, 39) being realised by the gripping means (14, 15) moving the pipe (27, 28) relative to the tool means (11) in the separating plane (37), said separating cut simultaneously serving to form the welding contact surfaces (40, 41).

A form-fill-seal system includes a tube feeding system, an end seal carriage (420), and a computing device. The tube feeding system feeds a tube (410) of flexible material at a first velocity (v1). The computing device controls the end seal carriage (420) to cause an increase in a velocity of the end seal carriage to substantially the first velocity (v1), a start of a dwell time of the end seal mechanism (424, 422) on the tube (410) of flexible material while the velocity of the end seal carriage is at substantially the first velocity (v1), and an increase in the velocity of the end seal carriage to a second velocity (v2) during the dwell time. The end seal mechanism cuts a package (440) from the tube during the dwell time. The increase in the velocity of the end seal carriage to the second velocity (v2) results in an increased distance of the package from the tube.

Provided is a tube joining apparatus that allows a user to easily and properly set tubes to be joined, and can prevent occurrence of joining failures due to tube setting errors. A tube joining apparatus 1 includes a housing 10, a lid 22 relatively movable toward and away from the housing, a tube holding part 23 that holds a first tube T1 and a second tube T2 individually in a state of being placed side by side in an oblique direction D1 with respect to a height direction Z of the housing, and a tube pressing part 25 that presses the first tube and the second tube against each other as the lid relatively moves toward the housing.

A device for welding thermoplastic tubes to a welding method, and to a welding knife. The device is provided for welding thermoplastic tubes, wherein the tubes are placed into tube holders and squeezed with the aid of tube clamps. A welding knife is moved between the first and the second tube holder and severs the tubes in the process. Cut ends and residual ends are thereby produced. The cut ends are aligned with one another by a relative movement of one tube holder with respect to the other tube holder and, by a horizontal movement of the two tube holders, are welded simultaneously to form continuous tubes.

Systems and methods are disclosed that include generating a plasma treatment and applying the plasma treatment to end contact surfaces of a first profile and a second profile in a sterile environment, manipulating at least one of the first profile and the second profile to force contact between the end contact surface of the first profile and the end contact surface of the second profile to permanently connect, join, or weld the end contact surfaces of the first profile and the second profile together, thereby forming a sterile connection between the first profile and a second profile.