Provided is a method for forming an implant with an autonomous manufacturing device. The method includes accessing a first computer-readable reconstruction of a being's anatomy; accessing a second computer-readable reconstruction of an implant; accessing a third computer-readable reconstruction comprising the first computer-readable reconstruction superimposed with the second computer readable reconstruction; generating at least one computer-readable trace from a point cloud; and forming an implant with an autonomous manufacturing device, wherein the autonomous manufacturing device forms the implant into a shape defined by at least one dimension of the computer-readable trace.

A method of manufacturing an external breast prosthesis (12), includes the steps of providing a 3D image of the breast prosthesis, forming the breast prosthesis using an additive manufacturing process, in which additive manufacturing process the breast prosthesis is made by forming a structure of a thermoplastic elastomer, the structure corresponding to the 3D image of the breast prosthesis, wherein the structure is a reticulated solid foam.

A method for connecting at least two structural parts of an orthopedic component, wherein the structural parts are retained in an orienting device while oriented in relation to each other, and an intermediate space thus being formed between the structural parts. The orienting device and the structural parts together form a cavity, which has a flow connection to at least one feed connection, via which an adhesive for adhesively bonding the structural parts is introduced into the cavity.

The present invention relates to an article fabrication system having a plurality of material deposition tools containing one or more materials useful in fabricating the article, and a material deposition device having a tool interface for receiving one of the material deposition tools. A system controller is operably connected to the material deposition device to control operation of the material deposition device. Also disclosed is a method of fabricating an article using the system of the invention and a method of fabricating a living three-dimensional structure.

The present invention concerns a method for obtaining an implantable plate for healing a fractured joint of a patient, comprising the steps of: 1) providing a 3D representation of a bone structure in a zone around a joint fracture, the zone comprising essentially all fragments of broken or ruptured bones and at least the ends of unbroken bones which form part of the fractured joint; 2) identifying different bone fragments within said 3D representation; 3) simulating a reduction of said bone fragments into a full joint; 4) calculating optimal parameter values for an implantable plate; 5) obtaining the implantable plate taking into account the calculated parameter values, whereby in step 3, the reduction is simulated by automatedly fitting positions and orientations of said bone fragments to a 3D representation of a healthy joint of said patient.

The invention relates to a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device would have improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site.

Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.

Provided herein is a 3D printing system and related compositions, and method of using such, that can produce a polymeric microfiber having embedded microspheres encapsulating an active agent with micron precision and high spatial and temporal resolution.

An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen, having an outer surface, and defining a plurality of apertures through the outer surface, wherein the apertures are arranged in a micropattern; and a coating (e.g., polymeric coating) attached to the outer surface of the stent. The coating includes a base and a tissue engagement portion including a second surface facing outwardly from the stent, the tissue engagement portion including a structure that defines a plurality of holes extending inwardly from the second surface toward the base. The holes are arranged in a micropattern. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the structure applies a force that may reduce stent migration by creating an interlock between the vessel wall and the endoprosthesis.

A method for producing a three-dimensional object by an additive manufacturing process includes introducing at least one manufacturing material fed in a flowable state from at least one feed-in opening of at least one feed-in needle into a supporting material. After being fed in, the at least one manufacturing material is cured, but it remains flexible or elastic after curing. The contour and/or position of at least one part of the three-dimensional object within the support material is detected by at least one sensor.