The present invention suppresses the formation of a pocket in a wall of a puncture route when a dull needle is moved forward along the puncture route. In order to achieve such aim, the invention provides a needle to be inserted into a puncture route extending from skin to a blood vessel under the skin to puncture the blood vessel, wherein: the needle is formed in a tubular shape and has an inclined end face at a tip of the needle, the inclined end face being inclined relative to an axis of the needle, a tip end of the inclined end face defining an unsharp edge; the needle has a flexibility of needle elastic modulus nE=1-900 Nmm as defined by an equation to be set forth below; a material of the needle is a resin; and the needle is manufactured by injection molding using a ring-shaped gate.

A method of creating a feature on a needle. The method comprising the steps of providing a needle having a sharpened distal end for insertion into an insertion site on a subject, a proximal end, and a tubular wall defining an inner diameter and an outer diameter; gripping a distal portion of the needle about the outer diameter; gripping a proximal portion of the needle about an outer diameter; and applying a compressive force between the distal portion and the proximal portion sufficient to effect an outward buckling of the tubular wall, thereby increasing an outer diameter of the tubular wall between the distal portion and the proximal portion.

The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying. Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41. Further, provided are the support member 50, a method of producing the microneedle array 120, and a microneedle array unit 300 including a container 310.

A plunger gasket with reduced surface contact area including a body, a first side defining a first side surface, a second side defining a second side surface, and at least one surface feature projecting outwardly from at least one of the first or second side surfaces. In example embodiments, at least one surface feature projects outwardly from both the first and second side surfaces. By reducing the surface areas of contact between gaskets during manufacture and processing, the incidence of unintentional cohesion may be reduced or eliminated.

A syringe includes a syringe body, a syringe cone having a distal opening, and a connection arranged in the region of the syringe cone, wherein the syringe body includes a first material and the connection includes a second material, and wherein the first material is different from the second material and the second material is a softer material than the first material.

A microneedle assembly and a method of fabrication the assembly are provided. The microneedle assembly includes an array of microneedles attached to a base. Each of the microneedles comprise a tip, a needle shaft and a plurality of cantilevered barbs protruding outwardly from the needle shaft, where a plurality of the microneedles include two or more of the cantilevered barbs arranged in a series of concentric rings along the needle shaft of each of the plurality of microneedles. The microneedle assembly may be fabricated using a 3D printing technique, where one or more cantilevered layers are formed by exposing a photocurable liquid resin including monomer material to a light source to create initially horizontal, cantilevered barbs having a crosslinking gradient, and rinsing to remove an amount of un-crosslinked monomers from the cantilevered layers to induce curvature in the cantilevered barbs extending towards a direction of the lower crosslinking.

Provided is an inexpensive microneedle array with little dimensional error that can control, with high precision, the amount of a predetermined component to be introduced to the inner part of the skin, and a production method for this microneedle array. A foundation that is insoluble or sparingly soluble in inner part of the skin is overlaid on a mold. A plurality of frustum-shaped protrusions, which are insoluble or sparingly soluble in the raw material liquid, provided on a first main surface of the foundation are fit into a plurality of cone-shaped recesses. The raw material liquid in the plurality of cone-shaped recesses dries and, as a result, a plurality of microneedles, which are dissolvable in the inner part of the skin, are fixed to tip surfaces of the plurality of frustum-shaped protrusions.

A method for manufacturing a microprojection unit (10) according to the invention involves: a microprojection tool forming step of forming a microprojection tool (1) by bringing a projecting mold part (11) into contact from one surface (2D) side of a base sheet (2A) including a thermoplastic resin, and thus forming a protrusion (3) that protrudes from another surface (2U) side, and withdrawing the projecting mold part (11) from the interior of the protrusion (3); a joining step of joining the one surface (2D) side of the base sheet (2A), in which the microprojection tool (1) has been formed, and a tip end of a base component (4); and a cutting step of cutting the base sheet (2A), to which the base component (4) has been joined, along a contour (4L) of the base component (4) at a position more inward than the base component's contour (4L) in a planar view of the base sheet (2A) as viewed from the microprojection tool (1) side, to manufacture a microprojection unit (10).

The invention relates to a device (10) for shaping an elongated component (44), comprising: a shaping tool (12) that defines multiple molding points and delimits at least one cavity (20) in which the molding compound (18) introduced via the molding points can be received, at least one centering element (26) which is designed to receive an elongated component (22, 24) and guide same into the at least one cavity (20), wherein the at least one centering element (26) can be moved relative to the molding tool (12), and at least one drive device, by means of which the at least one centering element (26) can be driven so as to move relative to the molding tool (12).

A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor, the resin plate precursor production step including a positioning step of positioning the protruding pattern of the plate precursor and a center position of the recessed step portion, and a recessed pattern forming step of forming a recessed pattern having an inverted shape of the protruding pattern on the thermoplastic resin plate by pressing the protruding pattern of the heated plate precursor and the pedestal against the recessed step portion, thereafter cooling the plate precursor, and separating the plate precursor from the thermoplastic resin plate.