Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes controllable fluid pathways. The cartridge may include a syringe pump for moving fluid and/or gas, and one or more syringe valves or rotary valves for controlling which of the controllable fluid pathways is open for flow of the fluid and/or gas.

A method for filling a receptacle (7), which is at least partly gas-permeable with bulk filling material (2), includes subjecting the receptacle (7) at the outer side to an underpressure, in order to generate a feed of filling material through a filling material conduit (4) into the inside of the receptacle (7). The filling procedure is assisted by way of subjecting the filling material conduit (4) to pressure after completion of a first filling time.

A dosing device for feeding an infusion product includes: a tower for containing loose infusion product, tubular channels for feeding and discharging the product, first containers for receiving the product from the channels; each channel actuated by an actuation device for releasing a quantity of product; a fixed platform supporting the first containers, a plurality of elements for weighing the product in the containers and supported by the platform; a control unit in communication with each actuating device and with each weighing element, to detect the value measured by each element and actuate the corresponding channel until reaching the quantity of product. Reference elements are independent of the weighing elements are associated with the platform each supporting a weight of predetermined value; each reference element is in communication with the control unit to transmit a signal equivalent to the measured value of the reference weight by the reference element.

A safety device for a single-use mixing or storage system (10), especially for use in a biopharmaceutical process, includes a flexible bag (12) made from a film material and a support structure (14) receiving and supporting the bag (12) in several directions. The support structure (14) allows an expansion of the bag (12) in an expansion direction. The safety device further includes a detection unit (20) adapted to detect an expansion of the bag (12) in the expansion direction, and a control unit (28) connected to the detection unit (20) and adapted to initiate a safety measure in response to the expansion of the bag (12) in the expansion direction exceeds a given threshold.

A dispensing system comprises a main base with a hopper insertion hole. An upper base, fixed above the main base by spacers, comprises a stirrer insertion hole. A lower base, below the main base, has a hopper insertion hole with an aperture larger than a diameter of a hopper, and is coupled to the main base by a guide. A rotatable hopper, disposed in the insertion hole of the main base, comprises a bottom surface with metering holes. A stirrer, inside the hopper and fixed to the upper base, feeds material into the metering holes. A gate, on a bottom surface of the lower base, comprises a bottom surface with a dispensing hole. The gate diameter is greater than the hopper. A gate spring, between the bottom of the main base and an upper surface of the lower base, is mounted parallel to a sliding motion of the lower base. A vibration device agitates the assembly on the main base.

The disclosure relates to a capsule filling machine for filling two-piece capsules that each include a capsule upper part and a capsule lower part. The capsule filling machine includes a measuring device, the measuring device including a capacitive measuring system. The measuring device is downstream of the closing station. The capacitive measuring system includes a measuring section, along which the mass of the filled, closed capsule can be measured via the capacitive measuring system. The measuring device includes a guide device for the closed capsule, the guide device being configured to convey the filled, closed capsule from the capsule segment to the measuring section of the capacitive measuring system.

A method and system for forming a packaged product (100) and ensuring that the packaged product (100) is adequately filled. In one aspect, the method includes forming a product (101); introducing the product (101) into a package (103), thereby forming a packaged product (100); obtaining an x-ray image (201) of the packaged product (100); analyzing the x-ray image (201) utilizing a processor (118) to identify whether bounded contours (200) exist in the x-ray image (201) for each of the bounded contours (200), the processor (118) determining whether the bounded contour (200) is a threshold defect based at least in part on bounded area (208) of the bounded contour (200) for each of the threshold defects, the processor (118) classifying the threshold defect as one of a plurality of pre-determined defect types; and determining a source of at least one of the threshold defects in the packaged product (100) based at least in part on the classification of the at least one of the threshold defects.

Systems and methods for distributing a filling fluid are discussed. More particularly an exemplary filling system may include a reservoir holding a filling fluid for distribution. The filling system may also include a pump and filling nozzle fluidly coupled to the reservoir. A processor executes a filling module that when executed receives at least one input fluid property of the filling fluid and generates at least one set of operating parameters for controlling operation of the pump during a filling operation based at least in part on the fluid property. The generated set of operating parameters enable control of the pump to distribute the filling fluid through the filling nozzle, such that a fluid interface with a stable resting profile forms in the filling fluid in the filling nozzle adjacent to the nozzle opening after the filling fluid is distributed from the filling nozzle.

Systems and methods for distributing a filling fluid are discussed. More particularly an exemplary filling system may include a reservoir holding a filling fluid for distribution. The filling system may also include a pump and filling nozzle fluidly coupled to the reservoir. A processor executes a filling module that when executed receives at least one input fluid property of the filling fluid and generates at least one set of operating parameters for controlling operation of the pump during a filling operation based at least in part on the fluid property. The generated set of operating parameters enable control of the pump to distribute the filling fluid through the filling nozzle, such that a fluid interface with a stable resting profile forms in the filling fluid in the filling nozzle adjacent to the nozzle opening after the filling fluid is distributed from the filling nozzle.

Disclosed are methods and apparatuses for manufacturing a solid formulation for oral administration, comprising an edible substrate portion on which a composition comprising a first pharmaceutical active ingredient is deposited, and solid formulations made thereby. The methods comprise providing an edible substrate in the form of a film comprising a plurality of portions, spraying a liquid formulation comprising the active ingredient and a solvent onto an edible substrate portion and evaporating the solvent to form a solid composition deposited on the edible substrate portion; measuring the quantity of active ingredient supported by the edible substrate portion and comparing to a predetermined value, and dividing the edible substrate into the plurality of portions.