A closure arrangement for a vessel containing a pharmaceutical substance, having a stopper, a metal cap, for securing the stopper on the vessel, and an overcap made of plastic, wherein, for the purpose of identifying contents of the vessel, a wirelessly readable, electrical memory unit is connected to the closure arrangement. In order for a closure arrangement of the type in question to be improved further, in particular in respect of tamper-evident sealing the memory unit is operatively connected both to the overcap and to the stopper, and the operative connection has a lasting effect on the memory unit when the overcap is torn off.

Device for blocking a fluid product reservoir with a neck, having a cap, a fixing ring to hold the cap on the neck, the fixing ring having a cylindrical structure with wall parts separated by lateral windows, each wall part having at least one inner radial projection to hold the cap in the fixing ring, each lateral window having a lower edge provided with at least one rigid lug extending radially inwards from the lower edge. The rigid lugs, in the blocking position of the fixing ring, are arranged under a neck of the reservoir, to thus fix the fixing ring on the reservoir. A blocking cover is provided having a cylindrical wall and an upper wall and arranged around the fixing ring to lock said fixing ring in its blocking position. The upper surface of the cap has a deformation profile that engages, after assembly, with the fixing ring.

A rubber stopper for a medicine container has a rubber stopper body and a coating layer directly applied to a surface exposed in the medicine container. The coating layer is more flexible than a forming material of the rubber stopper body. The said coating layer comprises a composition containing a silicone-based resin which comprises a condensate of a reactive silicone having a terminal silanol group, and wherein the condensate contains a siloxane bond derived from the silanol group.

A pierceable cap 11 may be used for containing sample specimens. The pierceable cap 11 may prevent escape of sample specimens before transfer with a transfer device 43. The pierceable cap 11 may fit over a vessel 21. An access port in the shell of the pierceable cap 11 may allow passage of a transfer device 43 through the pierceable cap 11. At least one frangible layer 215, 216 may be configured with cross slits 506 in a particular cross slit geometry. The cross slits 506 may contain an openable portion 644 or be covered by a thin membrane 645. The shell 610 and frangible layer(s) 215, 216 may be integrated into a one piece cap 601, or be separate components 634. The membrane on which the cross slits 506 are placed can be flat or contoured to guide the transfer device 43 to the cross slits 506.

A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange includes an inclined sealing surface defining an opening in the sealed pharmaceutical container. The sealed pharmaceutical container also includes a sealing assembly including a stopper extending over the sealing surface of the flange and a cap securing the stopper to the flange. The stopper has a glass transition temperature (T.sub.g) that is greater than or equal to −70° C. and less than or equal to −45° C. The sealing assembly maintains a helium leakage rate of the sealed pharmaceutical container of less than or equal to 1.4×10.sup.−6 cm.sup.3/s as the sealed pharmaceutical container is cooled to a temperature of less than or equal to −45° C.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

An apparatus for collecting and storing fluid samples from vehicles and machinery comprises a storage container having a fluid inlet sealed by a cap, the cap having an aperture releasably sealed by a lid. An adapter connects the cap releasably to a fluid outlet coupling port of a fluid sampling device. The adapter comprises a lumen, having an inlet and an outlet aperture, an external screw thread engageable with an internal screw thread of the coupling port and a connector assembly for connecting the adapter releasably to the cap. A penetrable diaphragm provides an airtight seal over a storage region of the storage container. When the adapter is connected to the coupling port and the cap is connected to the adapter, a fluid outlet tube extending from the coupling port extends through the aperture and protrudes through one or more perforations provided in the penetrable diaphragm into the storage region.

A vial blinding assembly includes a vial having a bottle with a constricted neck and an annular shoulder that inwardly extends; a stopper disposed on an opening of the bottle and having a septum with a top surface; and a retainer securing the stopper to the bottle. A tubular blinding shell encircles a compartment that extends between a first end with an inlet opening and an opposing second end with an access opening. A floor plug is secured to the first end of the blinding shell. The vial is disposed within compartment of the blinding shell with the vial being supported by the floor plug and the neck passing through the access opening so that the top surface of the septum is disposed outside of the compartment of the blinding shell, the shoulder of the vial having an outside diameter larger than a diameter of the access opening.

A cap and seal system for a liquid medicament container. The system comprises a cap formed from a substantially rigid material, and has a retention component integrally formed therewith. A seal is formed from a material which is less hard than the cap and positioned within the cap such that, when the retaining component retains the cap on a container in use the seal is positioned such that it forms a fluid tight seal between the cap and the container. A recess is formed in the seal through which a liquid outlet channel can pass in use to access the contents of the container via the cap and the seal.

At least one closed container includes a glass container having a total height, being characterized by a center axis and including a shoulder region; and a press-fit cap closing the glass container and including a cylindrical body having an upper end and a lower end. P is any given point at the lower end of the press-fit cap that is located above the shoulder region and that lies on a straight line running parallel to the center axis and hitting an outer surface of the shoulder region at a point Q. Among these points P at the lower end of the press-fit cap point P′ is the one that has a smallest distance to its corresponding point Q′ and a distance between points P′ and Q′ on the straight line is in a range from 0.17 to 8.4 mm.